ID   DIRC2_XENLA             Reviewed;         456 AA.
AC   Q6GNV7;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Solute carrier family 49 member 4 homolog {ECO:0000305};
DE   AltName: Full=Disrupted in renal carcinoma protein 2 homolog;
GN   Name=slc49a4; Synonyms=dirc2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   SUBCELLULAR LOCATION, AND FUNCTION.
RX   PubMed=21692750; DOI=10.1042/bj20110166;
RA   Savalas L.R., Gasnier B., Damme M., Lubke T., Wrocklage C., Debacker C.,
RA   Jezegou A., Reinheckel T., Hasilik A., Saftig P., Schroder B.;
RT   "Disrupted in renal carcinoma 2 (DIRC2), a novel transporter of the
RT   lysosomal membrane, is proteolytically processed by cathepsin L.";
RL   Biochem. J. 439:113-128(2011).
CC   -!- FUNCTION: Electrogenic metabolite transporter.
CC       {ECO:0000269|PubMed:21692750}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC073394; AAH73394.1; -; mRNA.
DR   RefSeq; NP_001085824.1; NM_001092355.1.
DR   AlphaFoldDB; Q6GNV7; -.
DR   SMR; Q6GNV7; -.
DR   DNASU; 444251; -.
DR   GeneID; 444251; -.
DR   KEGG; xla:444251; -.
DR   CTD; 444251; -.
DR   Xenbase; XB-GENE-865779; slc49a4.L.
DR   OMA; NGFAWLM; -.
DR   OrthoDB; 702737at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 444251; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Lysosome; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..456
FT                   /note="Solute carrier family 49 member 4 homolog"
FT                   /id="PRO_0000271341"
FT   TOPO_DOM        1..29
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        30..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        51..67
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        89..95
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        117..123
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        124..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        145..162
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        163..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        184..207
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        208..228
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        229..259
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        260..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        281..292
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        293..313
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        314..326
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        327..347
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        348..362
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        363..383
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        384..392
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        393..413
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        414..420
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        421..441
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        442..456
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   MOTIF           14..15
FT                   /note="Mediates lysosomal localization"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        187
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        349
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   456 AA;  49951 MW;  6CD0F29B100261CE CRC64;
     MGLEWSSPGE RQPLLFPGGP RSPRVFGRRW LVLLLFSVLA FLQGLVWNSW GPIQISARTA
     YKFSGLDIAL LVLWGPIGFL PCFLFMWLMD NRGLRITVLL TALLMVLGAG LRCVPVEDLA
     IRRILIHGGQ LLNGFAGPTV MNAAPFLSTT WFAPDERATA TAIASMLNYL GGACAFLVGP
     LVVPAPNSTS GLLLYSGSTD AIKDRIEAVM YAEFGIIFVV FAAILAYFPA RPPVPPSVAA
     ASRRLSYRTS IFRLLSNLRF LLIVLAYAIP LGFYSGWIGV LDLILTPVHV TQVDAGWVGF
     WSIVGGCVVG IAVGRFADSI RGVLKPILLL LFSGATLSAT WFTLTFLSNV THLPLTTATL
     YTSCILIGVF LNGTVPIFFE LFVETVYPIP EGIACGVVTF LSNIFMGVLL VFLTMYQMEL
     SWLNWCLTGS CFLSLFFIAC FRESYDRLYL DVFVSV