DIRC2_XENTR
ID DIRC2_XENTR Reviewed; 456 AA.
AC Q501I9; Q28E64;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2005, sequence version 1.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Solute carrier family 49 member 4 homolog {ECO:0000305};
DE AltName: Full=Disrupted in renal carcinoma protein 2 homolog;
GN Name=slc49a4; Synonyms=dirc2; ORFNames=TEgg084h23.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Egg;
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Electrogenic metabolite transporter. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q501I9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q501I9-2; Sequence=VSP_022304, VSP_022305;
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
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DR EMBL; CR848430; CAJ81329.1; -; mRNA.
DR EMBL; BC096055; AAH96055.1; -; mRNA.
DR RefSeq; NP_001016971.2; NM_001016971.3. [Q501I9-1]
DR AlphaFoldDB; Q501I9; -.
DR SMR; Q501I9; -.
DR STRING; 8364.ENSXETP00000026265; -.
DR PaxDb; Q501I9; -.
DR DNASU; 549725; -.
DR GeneID; 549725; -.
DR KEGG; xtr:549725; -.
DR CTD; 84925; -.
DR Xenbase; XB-GENE-488397; slc49a4.
DR eggNOG; KOG2563; Eukaryota.
DR InParanoid; Q501I9; -.
DR OrthoDB; 702737at2759; -.
DR Proteomes; UP000008143; Chromosome 9.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000012022; Expressed in neurula embryo and 12 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Lysosome; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..456
FT /note="Solute carrier family 49 member 4 homolog"
FT /id="PRO_0000271342"
FT TOPO_DOM 1..29
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 51..67
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 89..95
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 117..131
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..152
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 153..162
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 184..207
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 208..228
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 229..259
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 260..280
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 281..292
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 293..313
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 314..326
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 327..347
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 348..362
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 363..383
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 384..392
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 393..413
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 414..420
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 421..441
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 442..456
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOTIF 14..15
FT /note="Mediates lysosomal localization"
FT /evidence="ECO:0000250"
FT CARBOHYD 62
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 187
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 349
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 419
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 367..370
FT /note="IGVF -> TLGH (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_022304"
FT VAR_SEQ 371..456
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_022305"
SQ SEQUENCE 456 AA; 49745 MW; F85B2B8CDB879A5D CRC64;
MGLEWSSPGE RQPLLYPGGP RAPRVFGRRW LVLLLFSLLA FLQGLVWNSW GPIQNSARTA
YNFSGLDIAL LVLWGPIGFL PCFLFMWLMD NRGLRVTVLL TALLMVLGAG LRCVPVQDLA
VRRKLIHGGQ LLNGFAGPTV MNAAPFLSTT WFSPDERATA TAIASMLSYL GGACAFLVGP
LVVPAPNSTS GLLLYSGSVG AIRDRIEAVM YAEFGIIFVV FAAILAYFPS RPPVPPSVAA
ASRRLSYRTS ILRLLSNVRF LLIVLAYAIP LGFYAGWSGV LDLILTPVHV TQVDAGWVGF
WSIVGGCVVG IAVGRFADSI RGVLKPILLL LFSGAALSST WFTLTFLSNV THLPLTTATL
YTSCILIGVF LSGTVPIFFE MFVETVYPIP EGITCGVVTF LSNLFMGVLL LFLTLYQTNL
SWLNWCLTGS CFLSLLFIAC FRESYDRLYL DVFVSV
