DIS1B_DICDI
ID DIS1B_DICDI Reviewed; 253 AA.
AC P02887; Q556R2;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 25-MAY-2022, entry version 150.
DE RecName: Full=Discoidin-1 subunit B/C;
DE AltName: Full=Discoidin I chain C/D;
DE AltName: Full=Discoidin-1 subunit beta/gamma;
GN Name=dscC-1; Synonyms=dscB-1; ORFNames=DDB_G0273065;
GN and
GN Name=dscC-2; Synonyms=dscB-2; ORFNames=DDB_G0273885;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6279874; DOI=10.1016/0022-2836(81)90278-3;
RA Poole S., Firtel R.A., Lamar E., Rowekamp W.;
RT "Sequence and expression of the discoidin I gene family in Dictyostelium
RT discoideum.";
RL J. Mol. Biol. 153:273-289(1981).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [4]
RP PROTEIN SEQUENCE OF 2-18; 70-79; 105-128; 131-146 AND 188-197, CLEAVAGE OF
RP INITIATOR METHIONINE, ACETYLATION AT SER-2, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RA Bienvenut W.V., Patel H., Brunton V.G., Frame M.C.;
RL Submitted (JUL-2007) to UniProtKB.
RN [5]
RP CELL ATTACHMENT SITE.
RX PubMed=6509552; DOI=10.1016/0092-8674(84)90462-8;
RA Springer W.R., Cooper D.N.W., Barondes S.H.;
RT "Discoidin I is implicated in cell-substratum attachment and ordered cell
RT migration of Dictyostelium discoideum and resembles fibronectin.";
RL Cell 39:557-564(1984).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=AX2;
RX PubMed=16926386; DOI=10.1074/mcp.m600113-mcp200;
RA Gotthardt D., Blancheteau V., Bosserhoff A., Ruppert T., Delorenzi M.,
RA Soldati T.;
RT "Proteomics fingerprinting of phagosome maturation and evidence for the
RT role of a Galpha during uptake.";
RL Mol. Cell. Proteomics 5:2228-2243(2006).
CC -!- FUNCTION: Galactose- and N-acetylgalactosamine-binding lectin. May play
CC a role in cell-substratum adhesion rather than in cell-cell adhesion.
CC May be necessary for the maintenance of normal elongate morphology
CC during aggregation.
CC -!- SUBUNIT: Tetramer of four different chains (A to D).
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- TISSUE SPECIFICITY: Stalk cells.
CC -!- CAUTION: The gene for this protein is duplicated in strains AX3 and
CC AX4. These strains contain a duplication of a segment of 750 kb of
CC chromosome 2 compared to the corresponding sequence in strain AX2.
CC {ECO:0000305}.
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DR EMBL; J01284; AAA33199.1; -; Genomic_DNA.
DR EMBL; J01283; AAA33198.1; -; Genomic_DNA.
DR EMBL; AAFI02000011; EAL70633.1; -; Genomic_DNA.
DR EMBL; AAFI02000009; EAL70750.1; -; Genomic_DNA.
DR PIR; A03382; DLDOIC.
DR PIR; B03382; B03382.
DR RefSeq; XP_644559.1; XM_639467.1.
DR RefSeq; XP_644692.1; XM_639600.1.
DR AlphaFoldDB; P02887; -.
DR SMR; P02887; -.
DR ELM; P02887; -.
DR SWISS-2DPAGE; P02887; -.
DR PaxDb; P02887; -.
DR EnsemblProtists; EAL70633; EAL70633; DDB_G0273885.
DR EnsemblProtists; EAL70750; EAL70750; DDB_G0273065.
DR GeneID; 8618789; -.
DR GeneID; 8619187; -.
DR KEGG; ddi:DDB_G0273065; -.
DR KEGG; ddi:DDB_G0273885; -.
DR dictyBase; DDB_G0273065; dscC-1.
DR dictyBase; DDB_G0273885; dscC-2.
DR eggNOG; KOG3516; Eukaryota.
DR HOGENOM; CLU_1100181_0_0_1; -.
DR InParanoid; P02887; -.
DR OMA; IDCANDK; -.
DR PhylomeDB; P02887; -.
DR PRO; PR:P02887; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0009986; C:cell surface; IDA:dictyBase.
DR GO; GO:0005737; C:cytoplasm; IDA:dictyBase.
DR GO; GO:0031012; C:extracellular matrix; HDA:dictyBase.
DR GO; GO:0098636; C:protein complex involved in cell adhesion; IDA:dictyBase.
DR GO; GO:0030246; F:carbohydrate binding; IDA:dictyBase.
DR GO; GO:0046871; F:N-acetylgalactosamine binding; IDA:dictyBase.
DR GO; GO:0070492; F:oligosaccharide binding; IBA:GO_Central.
DR GO; GO:0030247; F:polysaccharide binding; IDA:dictyBase.
DR GO; GO:0007155; P:cell adhesion; IDA:dictyBase.
DR GO; GO:0098609; P:cell-cell adhesion; IDA:dictyBase.
DR GO; GO:0007010; P:cytoskeleton organization; IMP:dictyBase.
DR GO; GO:0051591; P:response to cAMP; IDA:dictyBase.
DR GO; GO:0051593; P:response to folic acid; IDA:dictyBase.
DR CDD; cd00057; FA58C; 1.
DR Gene3D; 2.60.40.2080; -; 1.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR037221; H-type_lectin_dom_sf.
DR InterPro; IPR019019; H-type_lectin_domain.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF09458; H_lectin; 1.
DR SMART; SM00231; FA58C; 1.
DR SUPFAM; SSF141086; SSF141086; 1.
DR SUPFAM; SSF49785; SSF49785; 1.
DR PROSITE; PS01285; FA58C_1; 1.
DR PROSITE; PS50022; FA58C_3; 1.
PE 1: Evidence at protein level;
KW Acetylation; Cell adhesion; Cytoplasm; Direct protein sequencing; Lectin;
KW Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|Ref.4"
FT CHAIN 2..253
FT /note="Discoidin-1 subunit B/C"
FT /id="PRO_0000079917"
FT DOMAIN 2..152
FT /note="F5/8 type C"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00081"
FT MOTIF 79..81
FT /note="Cell attachment site"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0000269|Ref.4"
SQ SEQUENCE 253 AA; 28392 MW; 875EA94811F85444 CRC64;
MSTQGLVQLI SNAQCHLRTS TNYNDVHTQF NAVLNYKNKG TNTIDGSEAW CSSIVDTNQY
IVAGCEVPRT FMCVALQGRG DHDQWVTSYK IRYSLDNVTW SEYRNGAAIT GVTDRNTVVN
HFFDTPIRAR SIAIHPLTWN NHISLRCEFY TQPVQSSVTQ VGADIYTGDN CALNTGSGKR
EVVVPVKFQF EFATLPKVAL NFDQIDCTDA TNQTRIGVQP RNITTKGFDC VFYTWNANKV
YSLRADYIAT ALE
