ID   ADCK1_CHICK             Reviewed;         519 AA.
AC   Q5ZMT7;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=AarF domain-containing protein kinase 1 {ECO:0000305};
DE            EC=2.7.-.- {ECO:0000255|PROSITE-ProRule:PRU00159};
DE   Flags: Precursor;
GN   Name=ADCK1; ORFNames=RCJMB04_1d9;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Appears to be essential for maintaining mitochondrial cristae
CC       formation and mitochondrial function by acting via YME1L1 in a kinase-
CC       independent manner to regulate essential mitochondrial structural
CC       proteins OPA1 and IMMT (By similarity). The action of this enzyme is
CC       not yet clear. It is not known if it has protein kinase activity and
CC       what type of substrate it would phosphorylate (Ser, Thr or Tyr)
CC       (Probable). {ECO:0000250|UniProtKB:Q86TW2, ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. ADCK protein
CC       kinase family. {ECO:0000305}.
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DR   EMBL; AJ719297; CAG30956.1; -; mRNA.
DR   RefSeq; NP_001073199.1; NM_001079731.1.
DR   AlphaFoldDB; Q5ZMT7; -.
DR   SMR; Q5ZMT7; -.
DR   STRING; 9031.ENSGALP00000017088; -.
DR   PaxDb; Q5ZMT7; -.
DR   GeneID; 423382; -.
DR   KEGG; gga:423382; -.
DR   CTD; 57143; -.
DR   VEuPathDB; HostDB:geneid_423382; -.
DR   eggNOG; KOG1235; Eukaryota.
DR   InParanoid; Q5ZMT7; -.
DR   PhylomeDB; Q5ZMT7; -.
DR   PRO; PR:Q5ZMT7; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0032592; C:integral component of mitochondrial membrane; IBA:GO_Central.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0055088; P:lipid homeostasis; IBA:GO_Central.
DR   GO; GO:0007005; P:mitochondrion organization; IBA:GO_Central.
DR   GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR   CDD; cd13969; ADCK1-like; 1.
DR   InterPro; IPR004147; ABC1_dom.
DR   InterPro; IPR045307; ADCK1_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   Pfam; PF03109; ABC1; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Kinase; Nucleotide-binding; Reference proteome; Secreted;
KW   Serine/threonine-protein kinase; Signal; Transferase.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..519
FT                   /note="AarF domain-containing protein kinase 1"
FT                   /id="PRO_0000252251"
FT   DOMAIN          145..481
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   ACT_SITE        305
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   BINDING         151..159
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   BINDING         173
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
SQ   SEQUENCE   519 AA;  59201 MW;  B770875CB6592577 CRC64;
     MARRALKLAS LAAAASGIYL YGNKFMDPND FGVVRVGRAI ATTAVITYDY LTSLRNVPYG
     SEEYDFLKSQ VHLRSAERLR ELCCANRGTF IKVGQHLGAL DYLLPEEYTR TLKVLHSQAP
     QSTRQEIEQV IREDLGKEIK ELFVSFEDTP LGAASLAQVH KAVLQDGRTV AVKIQHPKVQ
     AQSSKDIFLM EVLLLVVKQI FPDFEFMWLV EEAKKNLPLE LDFLNEGRNA EKVAQMLKNF
     EFLKVPRIYW ELSTRRVLLM EFMEGGQVND KAYMEKNGID VNEISRNLGK LYSEMIFVNG
     FVHCDPHPGN VLVKKCPDSG KAYIILLDHG LYQVLSESFR MDYCRLWLAL IKADMKRVQK
     YSRRLGAGDL YPLFACMLTA RSWESVNRGI DQSPVSASED VEIRSNAAAY LPQITQLLNN
     VPRQMLLLLK TNDLLRGIES ALHTRASASS FLNMSRCCIR AVSTYQRSKS HSLYRRVHIS
     LTEALSLWQI NLYELFLWLK GSRLGSWVIA FLSRMHHST