ID   ADCK1_XENLA             Reviewed;         520 AA.
AC   Q6INL7;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=AarF domain-containing protein kinase 1 {ECO:0000250|UniProtKB:Q86TW2};
DE            EC=2.7.-.- {ECO:0000255|PROSITE-ProRule:PRU00159};
DE   Flags: Precursor;
GN   Name=adck1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Appears to be essential for maintaining mitochondrial cristae
CC       formation and mitochondrial function by acting via YME1L1 in a kinase-
CC       independent manner to regulate essential mitochondrial structural
CC       proteins OPA1 and IMMT (By similarity). The action of this enzyme is
CC       not yet clear. It is not known if it has protein kinase activity and
CC       what type of substrate it would phosphorylate (Ser, Thr or Tyr)
CC       (Probable). {ECO:0000250|UniProtKB:Q86TW2, ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. ADCK protein
CC       kinase family. {ECO:0000305}.
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DR   EMBL; BC072263; AAH72263.1; -; mRNA.
DR   RefSeq; NP_001085405.1; NM_001091936.1.
DR   AlphaFoldDB; Q6INL7; -.
DR   SMR; Q6INL7; -.
DR   DNASU; 443831; -.
DR   GeneID; 443831; -.
DR   KEGG; xla:443831; -.
DR   CTD; 443831; -.
DR   Xenbase; XB-GENE-1006950; adck1.L.
DR   Proteomes; UP000186698; Chromosome 8L.
DR   Bgee; 443831; Expressed in neurula embryo and 16 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR   CDD; cd13969; ADCK1-like; 1.
DR   InterPro; IPR004147; ABC1_dom.
DR   InterPro; IPR045307; ADCK1_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   Pfam; PF03109; ABC1; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Kinase; Nucleotide-binding; Reference proteome; Secreted;
KW   Serine/threonine-protein kinase; Signal; Transferase.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..520
FT                   /note="AarF domain-containing protein kinase 1"
FT                   /id="PRO_0000252252"
FT   DOMAIN          148..455
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   ACT_SITE        308
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   BINDING         154..162
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   BINDING         176
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
SQ   SEQUENCE   520 AA;  59544 MW;  468DA30BE7690E77 CRC64;
     MVRGIIRIAS LASVSLSSSG FFLYGTGYWD PSDFGVVRIG RAVLTTAAIT WDYFTKLRHV
     EAGTEEYENI KSQVHLRSAH RLLDLCCFNR GTFIKVGQHL AALEYLVPPE YTKTLSVLHS
     QAPCTPFTDV VQVIREDLGK EISEVFEEFE KTPLGAASLA QVHRAVLQDG RKVAVKVQHP
     KVQAQSSRDI LIMEVLLHVV KKIFPQFEFM WLIEEAKKNL PLELDFQNEG RNAEKMSSIV
     SSFSFLRIPR IYWELSTKRV LVMEYMEGGQ VNDREYMKRN QIDVNKVSHA LGKLYSEMIF
     VHGFVHCDPH PGNVLVRQNP ENCAPEIILL DHGLYQVLTE SFRLDYCSLW QALIAADKER
     IRIYSQRLGA GELYPLFACM LTARSWESVN RGIYENTVSK EEIHEIRSNA ATYLPEISQL
     LASVPRQMLL LLKTNDLLRG IETSLGTHSS SSAFFYMSRC CVRALARHRK EKADSLWSYI
     HISLSETFCL GQLQMYEIAL RLQSCIGRWI NHVLLWLYLQ