ID   ADCK1_XENTR             Reviewed;         523 AA.
AC   Q5M7P6;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=AarF domain-containing protein kinase 1 {ECO:0000250|UniProtKB:Q86TW2};
DE            EC=2.7.-.- {ECO:0000255|PROSITE-ProRule:PRU00159};
DE   Flags: Precursor;
GN   Name=adck1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Appears to be essential for maintaining mitochondrial cristae
CC       formation and mitochondrial function by acting via YME1L1 in a kinase-
CC       independent manner to regulate essential mitochondrial structural
CC       proteins OPA1 and IMMT (By similarity). The action of this enzyme is
CC       not yet clear. It is not known if it has protein kinase activity and
CC       what type of substrate it would phosphorylate (Ser, Thr or Tyr)
CC       (Probable). {ECO:0000250|UniProtKB:Q86TW2, ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. ADCK protein
CC       kinase family. {ECO:0000305}.
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DR   EMBL; BC088521; AAH88521.1; -; mRNA.
DR   RefSeq; NP_001011357.1; NM_001011357.1.
DR   RefSeq; XP_017951731.1; XM_018096242.1.
DR   AlphaFoldDB; Q5M7P6; -.
DR   SMR; Q5M7P6; -.
DR   STRING; 8364.ENSXETP00000040888; -.
DR   PaxDb; Q5M7P6; -.
DR   PRIDE; Q5M7P6; -.
DR   DNASU; 496824; -.
DR   GeneID; 496824; -.
DR   KEGG; xtr:496824; -.
DR   CTD; 57143; -.
DR   Xenbase; XB-GENE-1006945; adck1.
DR   eggNOG; KOG1235; Eukaryota.
DR   InParanoid; Q5M7P6; -.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000011088; Expressed in neurula embryo and 13 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0032592; C:integral component of mitochondrial membrane; IBA:GO_Central.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0055088; P:lipid homeostasis; IBA:GO_Central.
DR   GO; GO:0007005; P:mitochondrion organization; IBA:GO_Central.
DR   GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR   CDD; cd13969; ADCK1-like; 1.
DR   InterPro; IPR004147; ABC1_dom.
DR   InterPro; IPR045307; ADCK1_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   Pfam; PF03109; ABC1; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Kinase; Nucleotide-binding; Reference proteome; Secreted;
KW   Serine/threonine-protein kinase; Signal; Transferase.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..523
FT                   /note="AarF domain-containing protein kinase 1"
FT                   /id="PRO_0000252253"
FT   DOMAIN          148..484
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   ACT_SITE        308
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   BINDING         154..162
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   BINDING         176
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
SQ   SEQUENCE   523 AA;  59623 MW;  C977F05531D901F0 CRC64;
     MVRGIIRVVS LASVSLTSSG FFLYGTGHWD PSDFGVVRIG RAVLTTAAIT WDYLTELRHV
     KAGTEEYESI KSQVHFRSAH RLLDLCCANR GTFIKVGQHL GALEYLVPPE YTKTLSVLHS
     QAPCTPFPDV VQVIREDLGK EISEVFVEFE EKPLGAASLA QVHRAVLQDG RKVAVKVQHP
     KVQAQSARDI LLMEVLLHAV KKIFPQFEFM WLIEEAKKNL PLELDFENEG RNAEKMSAIV
     SSFSFLRIPR IYWELSTKRV LVMEYMEGGQ VNDREYMKRN QIDINQVARA LGQLYSEMIF
     VHGFVHCDPH PGNVLVRQNP ETLVPEIILL DHGLYQVLTE SFRLDYCSLW QALIAADMQQ
     IRIYSQRLGA GELYPLFACM LTARSWESVN QGIYQNTVSR EEALEIRSNA ATYLPEISQL
     LASVPRQMLL LLKTNDLLRG IETSLGTHAS SSSFLNMSRC CVRALARHRK EKTDSLWSYI
     HISLAETFSL GQLQIYEIVL RLQASCVGCW IRRMMQWVFL YIH