ID   DISP2_DANRE             Reviewed;        1476 AA.
AC   Q6R5J1;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Protein dispatched homolog 2;
GN   Name=disp2;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX   PubMed=15110707; DOI=10.1016/j.ydbio.2004.01.022;
RA   Nakano Y., Kim H.R., Kawakami A., Roy S., Schier A.F., Ingham P.W.;
RT   "Inactivation of dispatched 1 by the chameleon mutation disrupts hedgehog
RT   signalling in the zebrafish embryo.";
RL   Dev. Biol. 269:381-392(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: Ubiquitously expressed throughout the embryo from
CC       fertilization onward. Accumulates at higher levels in cells of the
CC       telencephalon, the ventral hindbrain and the gut.
CC       {ECO:0000269|PubMed:15110707}.
CC   -!- SIMILARITY: Belongs to the dispatched family. {ECO:0000305}.
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DR   EMBL; AY512780; AAR99504.1; -; mRNA.
DR   RefSeq; NP_997599.1; NM_212434.2.
DR   AlphaFoldDB; Q6R5J1; -.
DR   SMR; Q6R5J1; -.
DR   STRING; 7955.ENSDARP00000105116; -.
DR   PaxDb; Q6R5J1; -.
DR   Ensembl; ENSDART00000062887; ENSDARP00000062886; ENSDARG00000042846.
DR   GeneID; 405793; -.
DR   KEGG; dre:405793; -.
DR   CTD; 85455; -.
DR   ZFIN; ZDB-GENE-030915-1; disp2.
DR   eggNOG; KOG3664; Eukaryota.
DR   GeneTree; ENSGT00940000159551; -.
DR   HOGENOM; CLU_004076_1_1_1; -.
DR   InParanoid; Q6R5J1; -.
DR   OMA; GCPVAIV; -.
DR   OrthoDB; 1156918at2759; -.
DR   PhylomeDB; Q6R5J1; -.
DR   Reactome; R-DRE-5362798; Release of Hh-Np from the secreting cell.
DR   PRO; PR:Q6R5J1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 17.
DR   Bgee; ENSDARG00000042846; Expressed in brain and 5 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0035195; P:miRNA-mediated gene silencing; IGI:ZFIN.
DR   GO; GO:0007224; P:smoothened signaling pathway; IBA:GO_Central.
DR   GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR003392; Ptc/Disp.
DR   InterPro; IPR000731; SSD.
DR   Pfam; PF02460; Patched; 1.
DR   Pfam; PF12349; Sterol-sensing; 1.
DR   PROSITE; PS50156; SSD; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..1476
FT                   /note="Protein dispatched homolog 2"
FT                   /id="PRO_0000310698"
FT   TRANSMEM        185..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        506..526
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        528..548
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        550..570
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        602..622
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        635..655
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        729..749
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1000..1020
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1023..1043
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1047..1067
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1098..1118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1121..1141
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          495..656
FT                   /note="SSD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00199"
FT   REGION          1..84
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1447..1476
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..17
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        41..84
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1462..1476
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        58
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        366
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        478
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        479
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        817
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        827
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        846
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1245
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1339
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1391
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1476 AA;  164020 MW;  F182C710E5DF61FF CRC64;
     MESGSISRQR EDAEMPDSST TEGPSLEAPQ SEIPEVSLCP PDSDSTESQM CPVEIEENQT
     KSSSPFNSHS STQLERQVSQ GSAYHSPPHK KCPCCGHQQP SQSDVCPGQM NALHQADCAA
     SPVKTLYSCS PSRLPSCHTK MQCHWLHGSH DGSNHKPVQH HMVTVRNDGL HRIPRSYSQV
     IVEYPMTVLI SCTLVLFACS LAGILTGPLP DFSDPLLGFE PRGTDISVRL ATWTRLKQNT
     GPGKPLSPVP WQLTEKTTTG KDTIKSEPQF RERSRRMLHR DNAEHNFFCN APGERYAQLV
     FRSGNSASLW SLKAIYSMCQ MEQTQIRSGP QFDKLCQVKS EFYGSMVKNE CCPSWSLGNY
     LAVLNNISSC FSLTSQQVSE SLGLLRFCAP YYHDGSLIAS CTERSKFGRC ASVPHRCKLS
     SIFQILHYLV DKDFLGPQTV EYKVPSLKYS IVFLPVEKSD SLMNIYLDHL EGHKLTYNNT
     TITGMDLGIK QKLFKYYLAR DSIYPVLAAL ALLITIGLYL KSLFIAAMSL VAVILSLSTS
     YFFYKVAFRL TFFPLLNLAA VFVLLGSCLN QALTFVDFWK LQLSHNPPAV PEKRMNRVLQ
     EMGYLIIVSG LTSSVTFYSG YISSITAVRC YAVYLGSASL INTLFALVWL PCTLILQERY
     AVLSSNTVGK VAWKPCCSKN AGGFWETSSR KRCLFTFRQK LRTLGRGFSD TSNLLFLKIL
     PCGVVKFRYI WICWFAVLAA GGTYISCVDP GMKLPTSDSR TTQLFRSSHP FERYDAEYRH
     QFMFERMKDG EDEPMMLTLI WGIVPSDNGD HFDPKSNGSL SVDPGFNMSS LQAQIWLRDL
     CGKIQNQTFY SPLSAEQDTA EDNVCFVEHL IHWVSIRRCS ESEDAFSFCC NNIPFPYPPR
     VFEQCLSMMV AEQHAEGRLP SAGGLRFDSE GRIAALVVIF KTVQLYSFNY NRMSQFYQEI
     LSWFNREISK APAGLQRGWF VSQLGLYDLQ QCLSSETLEV AGFSVALTFA LLLLTTWNIP
     LSVYVSIAVA GSVFATVGLL VLLEWQLNGV EALFISAAAG LSVDFVANYC ISYSLAPHSD
     RLGRVAHSIK RMGCPVATGA GAYFCVGIIM LPATALLFRK LGIFLLLVKC VACGFATFFF
     QSLCCFFGPQ NNCGRITLPC VTQQSTENIL SSCSATEPGT NNPAANGAFG CGKGSRVRRS
     FNKENEGFLC PNQQHHRKRQ PVGGREPEQN ELQPLACQLS DSFENSTCTS KLSNRPSVLS
     DDIQFCGLSP KQDYDRVSIE ADSTEMCSRH LKGCNPPPAL QTSSPYKENM LRLPQDACKE
     KVLCKKCRGQ SRGGLQLWNV SLSSSSSMDE IMITQTTDTV NERSLSMDDH IHKRLLSCQS
     QSSIEGLEES NDTCLTEVEA AIPQAGKIED EFQPGHLNGK RDTLRLSLKE TVYDLASPGS
     GRVRTAQSDV PVILPNSKPD MPDVWIKREG KGEGGS