DISP2_HUMAN
ID DISP2_HUMAN Reviewed; 1401 AA.
AC A7MBM2; Q6AHW3; Q9C0C1;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2007, sequence version 2.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Protein dispatched homolog 2;
GN Name=DISP2 {ECO:0000312|HGNC:HGNC:19712};
GN Synonyms=C15orf36 {ECO:0000312|HGNC:HGNC:19712}, DISPB, KIAA1742,
GN LINC00594 {ECO:0000312|HGNC:HGNC:19712};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ALA-47 AND SER-56.
RC TISSUE=Brain;
RX PubMed=11214970; DOI=10.1093/dnares/7.6.347;
RA Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XIX. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:347-355(2000).
RN [2]
RP SEQUENCE REVISION.
RX PubMed=12168954; DOI=10.1093/dnares/9.3.99;
RA Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.;
RT "Construction of expression-ready cDNA clones for KIAA genes: manual
RT curation of 330 KIAA cDNA clones.";
RL DNA Res. 9:99-106(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human chromosome
RT 15.";
RL Nature 440:671-675(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-665, AND VARIANTS ALA-47 AND
RP SER-56.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1279-1401.
RC TISSUE=Brain;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the dispatched family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB21833.2; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB051529; BAB21833.2; ALT_SEQ; mRNA.
DR EMBL; AC013356; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC151833; AAI51834.1; -; mRNA.
DR EMBL; CR627480; CAH10680.1; -; mRNA.
DR CCDS; CCDS10056.1; -.
DR RefSeq; NP_277045.1; NM_033510.2.
DR RefSeq; XP_011520427.1; XM_011522125.2.
DR RefSeq; XP_016878176.1; XM_017022687.1.
DR AlphaFoldDB; A7MBM2; -.
DR SMR; A7MBM2; -.
DR BioGRID; 124539; 3.
DR STRING; 9606.ENSP00000267889; -.
DR GlyGen; A7MBM2; 4 sites.
DR iPTMnet; A7MBM2; -.
DR PhosphoSitePlus; A7MBM2; -.
DR BioMuta; DISP2; -.
DR jPOST; A7MBM2; -.
DR MassIVE; A7MBM2; -.
DR MaxQB; A7MBM2; -.
DR PaxDb; A7MBM2; -.
DR PeptideAtlas; A7MBM2; -.
DR PRIDE; A7MBM2; -.
DR ProteomicsDB; 1809; -.
DR Antibodypedia; 23061; 94 antibodies from 24 providers.
DR DNASU; 85455; -.
DR Ensembl; ENST00000267889.5; ENSP00000267889.3; ENSG00000140323.6.
DR GeneID; 85455; -.
DR KEGG; hsa:85455; -.
DR MANE-Select; ENST00000267889.5; ENSP00000267889.3; NM_033510.3; NP_277045.1.
DR UCSC; uc001zlk.2; human.
DR CTD; 85455; -.
DR DisGeNET; 85455; -.
DR GeneCards; DISP2; -.
DR HGNC; HGNC:19712; DISP2.
DR HPA; ENSG00000140323; Tissue enriched (brain).
DR MIM; 607503; gene.
DR neXtProt; NX_A7MBM2; -.
DR OpenTargets; ENSG00000140323; -.
DR PharmGKB; PA134876083; -.
DR VEuPathDB; HostDB:ENSG00000140323; -.
DR eggNOG; KOG3664; Eukaryota.
DR GeneTree; ENSGT00940000159551; -.
DR HOGENOM; CLU_004076_1_1_1; -.
DR InParanoid; A7MBM2; -.
DR OMA; GCPVAIV; -.
DR OrthoDB; 1156918at2759; -.
DR PhylomeDB; A7MBM2; -.
DR TreeFam; TF324144; -.
DR PathwayCommons; A7MBM2; -.
DR Reactome; R-HSA-5362798; Release of Hh-Np from the secreting cell.
DR SignaLink; A7MBM2; -.
DR BioGRID-ORCS; 85455; 16 hits in 1068 CRISPR screens.
DR ChiTaRS; DISP2; human.
DR GenomeRNAi; 85455; -.
DR Pharos; A7MBM2; Tbio.
DR PRO; PR:A7MBM2; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; A7MBM2; protein.
DR Bgee; ENSG00000140323; Expressed in cerebellar cortex and 121 other tissues.
DR Genevisible; A7MBM2; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0007224; P:smoothened signaling pathway; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR InterPro; IPR000731; SSD.
DR PROSITE; PS50156; SSD; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Methylation; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..1401
FT /note="Protein dispatched homolog 2"
FT /id="PRO_0000310696"
FT TRANSMEM 170..190
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 484..504
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 510..530
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 542..562
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 589..609
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 617..637
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 704..724
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 964..984
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 990..1010
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1019..1039
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1064..1084
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1088..1108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 471..643
FT /note="SSD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00199"
FT REGION 1..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 113..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 241..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1169..1192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1229..1337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1352..1401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..84
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1172..1190
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1229..1248
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1286..1309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1366
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q8CIP5"
FT CARBOHYD 239
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 349
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 465
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 47
FT /note="P -> A (in dbSNP:rs1898883)"
FT /evidence="ECO:0000269|PubMed:11214970,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_037078"
FT VARIANT 56
FT /note="C -> S (in dbSNP:rs1898882)"
FT /evidence="ECO:0000269|PubMed:11214970,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_037079"
FT VARIANT 388
FT /note="G -> E (in dbSNP:rs35043215)"
FT /id="VAR_037080"
FT VARIANT 1145
FT /note="G -> S (in dbSNP:rs2412512)"
FT /id="VAR_037081"
FT VARIANT 1247
FT /note="R -> W (in dbSNP:rs3743142)"
FT /id="VAR_037082"
FT CONFLICT 67
FT /note="S -> F (in Ref. 1; BAB21833)"
FT /evidence="ECO:0000305"
FT CONFLICT 70
FT /note="S -> L (in Ref. 1; BAB21833)"
FT /evidence="ECO:0000305"
FT CONFLICT 77
FT /note="S -> F (in Ref. 1; BAB21833)"
FT /evidence="ECO:0000305"
FT CONFLICT 96
FT /note="P -> T (in Ref. 1; BAB21833)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1401 AA; 152003 MW; 67BD27DC491C72CE CRC64;
MDGDSSSSSG GSGPAPGPGP EGEQRPEGEP LAPDGGSPDS TQTKAVPPEA SPERSCSLHS
CPLEDPSSSS GPPPTTSTLQ PVGPSSPLAP AHFTYPRALQ EYQGGSSLPG LGDRAALCSH
GSSLSPSPAP SQRDGTWKPP AVQHHVVSVR QERAFQMPKS YSQLIAEWPV AVLMLCLAVI
FLCTLAGLLG ARLPDFSKPL LGFEPRDTDI GSKLVVWRAL QALTGPRKLL FLSPDLELNS
SSSHNTLRPA PRGSAQESAV RPRRMVEPLE DRRQENFFCG PPEKSYAKLV FMSTSSGSLW
NLHAIHSMCR MEQDQIRSHT SFGALCQRTA ANQCCPSWSL GNYLAVLSNR SSCLDTTQAD
AARTLALLRT CALYYHSGAL VPSCLGPGQN KSPRCAQVPT KCSQSSAIYQ LLHFLLDRDF
LSPQTTDYQV PSLKYSLLFL PTPKGASLMD IYLDRLATPW GLADNYTSVT GMDLGLKQEL
LRHFLVQDTV YPLLALVAIF FGMALYLRSL FLTLMVLLGV LGSLLVAFFL YQVAFRMAYF
PFVNLAALLL LSSVCANHTL IFFDLWRLSK SQLPSGGLAQ RVGRTMHHFG YLLLVSGLTT
SAAFYASYLS RLPAVRCLAL FMGTAVLVHL ALTLVWLPAS AVLHERYLAR GCARRARGRW
EGSAPRRLLL ALHRRLRGLR RAAAGTSRLL FQRLLPCGVI KFRYIWICWF AALAAGGAYI
AGVSPRLRLP TLPPPGGQVF RPSHPFERFD AEYRQLFLFE QLPQGEGGHM PVVLVWGVLP
VDTGDPLDPR SNSSLVRDPA FSASGPEAQR WLLALCHRAR NQSFFDTLQE GWPTLCFVET
LQRWMESPSC ARLGPDLCCG HSDFPWAPQF FLHCLKMMAL EQGPDGTQDL GLRFDAHGSL
AALVLQFQTN FRNSPDYNQT QLFYNEVSHW LAAELGMAPP GLRRGWFTSR LELYSLQHSL
STEPAVVLGL ALALAFATLL LGTWNVPLSL FSVAAVAGTV LLTVGLLVLL EWQLNTAEAL
FLSASVGLSV DFTVNYCISY HLCPHPDRLS RVAFSLRQTS CATAVGAAAL FAAGVLMLPA
TVLLYRKLGI ILMMVKCVSC GFASFFFQSL CCFFGPEKNC GQILWPCAHL PWDAGTGDPG
GEKAGRPRPG SVGGMPGSCS EQYELQPLAR RRSPSFDTST ATSKLSHRPS VLSEDLQLHD
GPCCSRPPPA PASPRELLLD HQAVFSQCPA LQTSSPYKQA GPSPKTRARQ DSQGEEAEPL
PASPEAPAHS PKAKAADPPD GFCSSASTLE GLSVSDETCL STSEPSARVP DSVGVSPDDL
DDTGQPVLER GQLNGKRDTL WLALRETVYD PSLPASHHSS LSWKGRGGPG DGSPVVLPNS
QPDLPDVWLR RPSTHTSGYS S
