DISP2_MOUSE
ID DISP2_MOUSE Reviewed; 1345 AA.
AC Q8CIP5; Q148A2; Q80T98; Q8CBA3;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Protein dispatched homolog 2;
GN Name=Disp2; Synonyms=Kiaa1742;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC STRAIN=129; TISSUE=Lung;
RX PubMed=12372301; DOI=10.1016/s0092-8674(02)00977-7;
RA Ma Y., Erkner A., Gong R., Yao S., Taipale J., Basler K., Beachy P.A.;
RT "Hedgehog-mediated patterning of the mammalian embryo requires transporter-
RT like function of dispatched.";
RL Cell 111:63-75(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Bone;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 378-1345 (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA Nakajima D., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: II.
RT The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:35-48(2003).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [7]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-1310, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8CIP5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8CIP5-2; Sequence=VSP_029324, VSP_029325;
CC -!- SIMILARITY: Belongs to the dispatched family. {ECO:0000305}.
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DR EMBL; AY150699; AAN52162.1; -; mRNA.
DR EMBL; AK036480; BAC29446.1; -; mRNA.
DR EMBL; AL772255; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC118526; AAI18527.1; -; mRNA.
DR EMBL; AK122547; BAC65829.1; -; mRNA.
DR CCDS; CCDS16584.1; -. [Q8CIP5-1]
DR RefSeq; NP_733481.1; NM_170593.3. [Q8CIP5-1]
DR RefSeq; XP_006499170.1; XM_006499107.2. [Q8CIP5-1]
DR AlphaFoldDB; Q8CIP5; -.
DR SMR; Q8CIP5; -.
DR STRING; 10090.ENSMUSP00000037136; -.
DR GlyGen; Q8CIP5; 3 sites.
DR iPTMnet; Q8CIP5; -.
DR PhosphoSitePlus; Q8CIP5; -.
DR SwissPalm; Q8CIP5; -.
DR MaxQB; Q8CIP5; -.
DR PaxDb; Q8CIP5; -.
DR PeptideAtlas; Q8CIP5; -.
DR PRIDE; Q8CIP5; -.
DR ProteomicsDB; 279776; -. [Q8CIP5-1]
DR ProteomicsDB; 279777; -. [Q8CIP5-2]
DR Antibodypedia; 23061; 94 antibodies from 24 providers.
DR DNASU; 214240; -.
DR Ensembl; ENSMUST00000037547; ENSMUSP00000037136; ENSMUSG00000040035. [Q8CIP5-1]
DR Ensembl; ENSMUST00000110846; ENSMUSP00000106470; ENSMUSG00000040035. [Q8CIP5-2]
DR GeneID; 214240; -.
DR KEGG; mmu:214240; -.
DR UCSC; uc008lsq.1; mouse. [Q8CIP5-1]
DR CTD; 85455; -.
DR MGI; MGI:2388733; Disp2.
DR VEuPathDB; HostDB:ENSMUSG00000040035; -.
DR eggNOG; KOG3664; Eukaryota.
DR GeneTree; ENSGT00940000159551; -.
DR HOGENOM; CLU_004076_1_1_1; -.
DR InParanoid; Q8CIP5; -.
DR OMA; GCPVAIV; -.
DR OrthoDB; 1156918at2759; -.
DR PhylomeDB; Q8CIP5; -.
DR TreeFam; TF324144; -.
DR Reactome; R-MMU-5362798; Release of Hh-Np from the secreting cell.
DR BioGRID-ORCS; 214240; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Disp2; mouse.
DR PRO; PR:Q8CIP5; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8CIP5; protein.
DR Bgee; ENSMUSG00000040035; Expressed in dorsomedial nucleus of hypothalamus and 115 other tissues.
DR ExpressionAtlas; Q8CIP5; baseline and differential.
DR Genevisible; Q8CIP5; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0007224; P:smoothened signaling pathway; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR InterPro; IPR000731; SSD.
DR Pfam; PF12349; Sterol-sensing; 1.
DR PROSITE; PS50156; SSD; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycoprotein; Membrane; Methylation;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..1345
FT /note="Protein dispatched homolog 2"
FT /id="PRO_0000310697"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 440..460
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 465..485
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 497..517
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 544..564
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 572..592
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 659..679
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 919..939
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 945..965
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 974..994
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1019..1039
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1043..1063
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 429..598
FT /note="SSD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00199"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1251..1271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1295..1345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1310
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT CARBOHYD 304
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 420
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 776
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 271..302
FT /note="IRSHISFGALCQRSAANECCPSWSLGNYLAVL -> EGSVRVPVVSAMWEAE
FT AGGLLEPRRPSTAWTT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_029324"
FT VAR_SEQ 303..1345
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_029325"
FT CONFLICT 1066
FT /note="C -> S (in Ref. 5; BAC65829)"
FT /evidence="ECO:0000305"
FT CONFLICT 1219
FT /note="S -> P (in Ref. 4; AAI18527 and 5; BAC65829)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1345 AA; 147944 MW; 931738C26FD3A57F CRC64;
MAPEASPERS CSLHTCPLED PTGAPVPPPT VSTLQAIDPT SPLTAGHFAF PRAPQDYQEG
SSLLGLGDQA SLCAHVSNLS TSIDTSQHDG VWKQPSVQRH VVSVRQERTF RMPKSYSHMI
ADWPVAVIVG CLAFIFLCTL AGLLGSPPLD FSEPLLGFEP RDTEIGRRLE VWKAMQALTG
PKNLLSLSPD PEMNSSSLLS TLSPAAWGRA EESVVRTKRM VGPVEVKEEE NFFCGRPEKS
HAKLVFVSTS GGSLWNLQAI HSMCRIEQEQ IRSHISFGAL CQRSAANECC PSWSLGNYLA
VLSNRSSCQD TTQADTDRTL ALLRFCATFY HRGVLVPACV GSSQDKPPFC AQVPAKCTGS
NVVYEFLHYL LDRDFLSPQT ADYQVPSLKF ALLFLPIIKT SSLLDIYLDG LGDPIKVSDN
YTSISGMDLG LKPRLLKYYL AEDTMYPLIA LVVIFFGMSL YLRSLFITFM SLLGVLGSLM
VAYFLYHVAF RMAYFPFVNL AALLLLSGVC VNYTLIFLDM WRLSRGQVPS GGMPHRVGRT
MHHFGYLLLV SGLTTSAAFY GSYLSRLPAV RCFALFMGTA VLVHMGLTLL WLPATVVLHE
RYLAHGCVAQ AHGQRGGSDP LRLLLALHRR IRIFRKIISI LSRLLFQRLL PCGVIKFRYI
WICWFAALAA GGAYIGGVSP RLQLPILLPL GGQFFRSSHP FERFDAEYRQ QFLFEDLPPN
EGGNLPVVLV WGILPVDTSD PLDPRTNSSV VSDPDFSPSS PEAQEWLLAL CHGAQNQSFF
GDQPEGWPTL CLVEALQQWM ESPSCGRLGP DLCCGQSEFP WAPQLYLHCL KMMALEQSPD
GTRDLGLRFD THGNLAALVL KFQTNLPYST EYGPVHHFYT EISRWLSTEM SKAPPGLNQG
WFTSNLELYS LQHSLSTEPA VVLGLALALA FATLLLSTWN VPLSLFSVAA VAGTVLLTVG
LLVLLEWQLN TAEALFLSAS VGLSVDLTIN YCISYHLCPH PDRLSRVAFS LRQISRATAM
TTGVLFASGV IMLPSTILLY RKLGIIVMMV KFLGCGFASF FFQSLCCFFG PEKNCGQILW
PCAHLPWDAG TEDPDEKGRA GPPGFSEHYE LQPLARRRSP SFDTSTATSK LSHRPSILSE
DLQIHDGSCC LQHAQAPVSP RDLLLDHQTV FSQCPALQTS SPYKQAGPTP QTWIRQDSQG
QKTEPLQALP EGPAHCPKSK VEELPDGLCS SASTLEGLSV SDDTCASEHS VRVPDSVGTS
PEVMNGTGHP ILERGQLNGK RDTLWLALKE TIYDPNMPNS HHSSLSWKGR GGPGDISPVM
LPNSQPDLPD VWLRRPSTYT SGYSS
