ID   DISTL_PITAZ             Reviewed;          77 AA.
AC   Q17UZ0;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 26.
DE   RecName: Full=Distinctin-like peptide;
DE   Flags: Precursor; Fragment;
GN   Name=ppdis-H1 {ECO:0000312|EMBL:CAK51559.1};
OS   Pithecopus azureus (Orange-legged monkey tree frog) (Phyllomedusa azurea).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Phyllomedusinae;
OC   Pithecopus.
OX   NCBI_TaxID=2034991;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:CAK51559.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 42-77, SUBCELLULAR
RP   LOCATION, AND TISSUE SPECIFICITY.
RC   TISSUE=Skin {ECO:0000312|EMBL:CAK51559.1}, and
RC   Skin secretion {ECO:0000269|Ref.1};
RA   Thompson A.H.;
RT   "A genomic/proteomic approach to isolating and identifying bioactive
RT   peptides from the skin secretions of Phyllomedusa hypochondrialis azurea.";
RL   Thesis (2006), University of Ulster Coleraine, United Kingdom.
CC   -!- FUNCTION: Has antimicrobial activity. {ECO:0000250|UniProtKB:Q9PT75}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands. {ECO:0000269|Ref.1}.
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AM269410; CAK51559.1; -; mRNA.
DR   AlphaFoldDB; Q17UZ0; -.
DR   SMR; Q17UZ0; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   InterPro; IPR004275; Frog_antimicrobial_propeptide.
DR   Pfam; PF03032; FSAP_sig_propep; 1.
PE   1: Evidence at protein level;
KW   Amphibian defense peptide; Antimicrobial;
KW   Cleavage on pair of basic residues; Direct protein sequencing; Secreted;
KW   Signal.
FT   SIGNAL          <1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..39
FT                   /evidence="ECO:0000269|Ref.1"
FT                   /id="PRO_0000250427"
FT   PEPTIDE         42..77
FT                   /note="Distinctin-like peptide"
FT                   /evidence="ECO:0000269|Ref.1"
FT                   /id="PRO_0000250428"
FT   NON_TER         1
FT                   /evidence="ECO:0000312|EMBL:CAK51559.1"
SQ   SEQUENCE   77 AA;  9164 MW;  D0A8E9BAF8789274 CRC64;
     LKKSLFLVTF LALVPLFLCE EEKREEENEE RQDDDQSEEK RNLVSALIEG RKYLKNVLKK
     LNRLKEKNKA KNSKENN