ADCK2_MOUSE
ID ADCK2_MOUSE Reviewed; 617 AA.
AC Q6NSR3; Q3TTS5; Q8BHC6;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Uncharacterized aarF domain-containing protein kinase 2;
DE EC=2.7.11.-;
GN Name=Adck2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head, and Skin;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: The function of this protein is not yet clear. It is not
CC known if it has protein kinase activity and what type of substrate it
CC would phosphorylate (Ser, Thr or Tyr).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. ADCK protein
CC kinase family. {ECO:0000305}.
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DR EMBL; AK028557; BAC26008.1; -; mRNA.
DR EMBL; AK028568; BAC26013.1; -; mRNA.
DR EMBL; AK161225; BAE36249.1; -; mRNA.
DR EMBL; BC069944; AAH69944.1; -; mRNA.
DR CCDS; CCDS20024.1; -.
DR RefSeq; NP_849204.1; NM_178873.3.
DR AlphaFoldDB; Q6NSR3; -.
DR STRING; 10090.ENSMUSP00000123563; -.
DR iPTMnet; Q6NSR3; -.
DR PhosphoSitePlus; Q6NSR3; -.
DR MaxQB; Q6NSR3; -.
DR PaxDb; Q6NSR3; -.
DR PRIDE; Q6NSR3; -.
DR ProteomicsDB; 285617; -.
DR DNASU; 57869; -.
DR GeneID; 57869; -.
DR KEGG; mmu:57869; -.
DR UCSC; uc009bmb.1; mouse.
DR CTD; 90956; -.
DR MGI; MGI:1889336; Adck2.
DR eggNOG; KOG1236; Eukaryota.
DR InParanoid; Q6NSR3; -.
DR OrthoDB; 1299789at2759; -.
DR TreeFam; TF315018; -.
DR BioGRID-ORCS; 57869; 3 hits in 75 CRISPR screens.
DR ChiTaRS; Adck2; mouse.
DR PRO; PR:Q6NSR3; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q6NSR3; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd13971; ADCK2-like; 1.
DR InterPro; IPR004147; ABC1_dom.
DR InterPro; IPR044095; ADCK2_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR Pfam; PF03109; ABC1; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Kinase; Membrane; Nucleotide-binding; Reference proteome;
KW Serine/threonine-protein kinase; Transferase; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..617
FT /note="Uncharacterized aarF domain-containing protein
FT kinase 2"
FT /id="PRO_0000271793"
FT TRANSMEM 103..123
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 200..609
FT /note="Protein kinase"
FT ACT_SITE 436
FT /note="Proton acceptor"
FT /evidence="ECO:0000250"
FT BINDING 206..214
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
FT BINDING 302
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
FT CONFLICT 342
FT /note="E -> K (in Ref. 1; BAE36249)"
FT /evidence="ECO:0000305"
FT CONFLICT 528
FT /note="R -> K (in Ref. 1; BAC26008/BAC26013/BAE36249)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 617 AA; 68677 MW; 3230111C7DB65CEC CRC64;
MVTPWRLSVR VCLSHLRCFE FRKELGHSRP LGCSRNARLC WFLLGTLPKL ISAHGSVGEG
APGSLCQRKT HWSDLAENGL VEKVAQEGPL ARVLLCLRLG LRAGVLLAKF FPLLFLYPLT
YLAPGLSTLW LHLLFKATET SGPTYIKLGQ WASTRRDLFS EAFCTQFSKL HVQVTPHPWA
RTEYLLQQAF GEDWGSLLFF ETREPVGSGC VAQVYKAFAS ISLLEEDRIW RLGELSAPGT
RAVVMQREPF MKDRKPSENL ADEAFLEKLL LPKADLGGSE VGVSQAPWHL PKSDHLIPVA
VKVLHPGLLS QVSMDLLLMK IGSKALGLLP GVKWLSLPEI VEEFEKLMVQ QTDLRYEAQN
LEHFQHNFQD MASVKFPTPL RPLITRDILV ETYEESVPVS SYQQAGIPTD LKRKIAQLGI
NMLLKMIFVD NFVHGDLHPG NILVQGADGV SPSLEMQQQQ VNVCDTLVAT IAPALCPLRL
VLLDAGIVAK LQASDLRNFR AVFQAVVMGQ GHRVAELMLH HAQANECRDV ERFKAEMATL
VTQARKNIVT LEKLHVSSLL SSVFKLLMTH KVKLESNFAS IVVAIMVLEG LGRSLDPTLD
ILEAAKPFLF KGPASFL
