ID   DIT1_YEAST              Reviewed;         536 AA.
AC   P21623; D6VT35;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 2.
DT   03-AUG-2022, entry version 148.
DE   RecName: Full=Spore wall maturation protein DIT1;
GN   Name=DIT1; OrderedLocusNames=YDR403W; ORFNames=D9509.21;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204510 / AB320;
RX   PubMed=2249774; DOI=10.1101/gad.4.10.1775;
RA   Briza P., Breitenbach M., Ellinger A., Segall J.;
RT   "Isolation of two developmentally regulated genes involved in spore wall
RT   maturation in Saccharomyces cerevisiae.";
RL   Genes Dev. 4:1775-1789(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169867;
RA   Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA   Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA   Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA   Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA   Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA   Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA   Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA   Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L.,
RA   Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H.,
RA   Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M.,
RA   Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M.,
RA   Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A.,
RA   Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G.,
RA   Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E.,
RA   Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S.,
RA   Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D.,
RA   Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V.,
RA   Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E.,
RA   Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M.,
RA   Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D.,
RA   Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X.,
RA   Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A.,
RA   Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA   Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T.,
RA   Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L.,
RA   Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E.,
RA   Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L.,
RA   Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M.,
RA   Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA   Mewes H.-W., Zollner A., Zaccaria P.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL   Nature 387:75-78(1997).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [4]
RP   CHARACTERIZATION.
RX   PubMed=8183942; DOI=10.1073/pnas.91.10.4524;
RA   Briza P., Eckerstorfer M., Breitenbach M.;
RT   "The sporulation-specific enzymes encoded by the DIT1 and DIT2 genes
RT   catalyze a two-step reaction leading to a soluble LL-dityrosine-containing
RT   precursor of the yeast spore wall.";
RL   Proc. Natl. Acad. Sci. U.S.A. 91:4524-4528(1994).
CC   -!- FUNCTION: Involved in spore wall maturation. Catalyzes a two step
CC       reaction that leads to the LL-dityrosine containing precursor of the
CC       spore wall.
CC   -!- DEVELOPMENTAL STAGE: Sporulation.
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DR   EMBL; X55712; CAA39245.1; -; Genomic_DNA.
DR   EMBL; U32274; AAB64843.1; -; Genomic_DNA.
DR   EMBL; BK006938; DAA12245.1; -; Genomic_DNA.
DR   PIR; A36395; A36395.
DR   RefSeq; NP_010691.1; NM_001180711.1.
DR   AlphaFoldDB; P21623; -.
DR   SMR; P21623; -.
DR   BioGRID; 32463; 81.
DR   DIP; DIP-5257N; -.
DR   IntAct; P21623; 15.
DR   STRING; 4932.YDR403W; -.
DR   PaxDb; P21623; -.
DR   PRIDE; P21623; -.
DR   EnsemblFungi; YDR403W_mRNA; YDR403W; YDR403W.
DR   GeneID; 852012; -.
DR   KEGG; sce:YDR403W; -.
DR   SGD; S000002811; DIT1.
DR   VEuPathDB; FungiDB:YDR403W; -.
DR   eggNOG; ENOG502QRI9; Eukaryota.
DR   HOGENOM; CLU_025510_0_1_1; -.
DR   InParanoid; P21623; -.
DR   OMA; VAFEMIK; -.
DR   BioCyc; YEAST:G3O-29947-MON; -.
DR   PRO; PR:P21623; -.
DR   Proteomes; UP000002311; Chromosome IV.
DR   RNAct; P21623; protein.
DR   GO; GO:0005829; C:cytosol; IDA:SGD.
DR   GO; GO:0003824; F:catalytic activity; IDA:SGD.
DR   GO; GO:0030476; P:ascospore wall assembly; IDA:SGD.
DR   InterPro; IPR007817; Isocyanide_synthase_DIT1.
DR   PANTHER; PTHR37285; PTHR37285; 1.
DR   Pfam; PF05141; DIT1_PvcA; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Sporulation.
FT   CHAIN           1..536
FT                   /note="Spore wall maturation protein DIT1"
FT                   /id="PRO_0000079920"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        273
FT                   /note="F -> S (in Ref. 1; CAA39245)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   536 AA;  61391 MW;  4E7C8AC0FD4EEDD8 CRC64;
     MTFTSNLPSS SEQSISPPAS SFSSSTDTLK DIDIPHNGAD LSTYSKFLAL YCRSDKCDDF
     YSLEEKQNCK FGDQWLDFIN TIHNLDFSES EVSGRVSERI LPASLANKFT NNLGVAIKIS
     EYTRDDERQI RGCVTTVENE NSFNNWFVYH ILDQSQLSLS EHPIVTKEVK YHELFADFFE
     KNLKNTIVND QWNFGGRDYF IERSRYFTDR YLRIECILPA FPCKSSNEQK VYGSVPDKGE
     ELALKRLIKA TQDLVKIYPP GMKIWIVSDG HVFSDCIGVD DDVVSTYTTK LHELYKRVAI
     PGVDAIGFCG LNDLFFSGAA SKVFDPKWVS DVEVAHYTGT QICPKSDLSR QILMKGCDTD
     AGRLRKQIAI EGHPRLHLYR GFSRFMMEDL SLLEHFQSYS RKKFKKIISM IAFNMIKRND
     AYSNLVELIF PHHLRISIHA HTNSGPKFGI KVISNEQCSI VSSLEDLDEP KFEDFLHIPT
     PWHNCVVKVE DEKEKYFLTK SKVVKEALEK GMYDGVWKDT RFDIGEGGHF VIKKIS