ADCK5_HUMAN
ID ADCK5_HUMAN Reviewed; 580 AA.
AC Q3MIX3; B3KS46; Q5U4P1; Q6P2S4; Q8N5V3;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 12-SEP-2018, sequence version 3.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Uncharacterized aarF domain-containing protein kinase 5;
DE EC=2.7.11.-;
GN Name=ADCK5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-17.
RC TISSUE=Small intestine;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, Colon, Ovary, and Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP VARIANT [LARGE SCALE ANALYSIS] ARG-17.
RX PubMed=17344846; DOI=10.1038/nature05610;
RA Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G.,
RA Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S.,
RA Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.,
RA Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K.,
RA Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D.,
RA Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R.,
RA Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A.,
RA Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F.,
RA Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F.,
RA Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G.,
RA Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R.,
RA Futreal P.A., Stratton M.R.;
RT "Patterns of somatic mutation in human cancer genomes.";
RL Nature 446:153-158(2007).
CC -!- FUNCTION: The function of this protein is not yet clear. It is not
CC known if it has protein kinase activity and what type of substrate it
CC would phosphorylate (Ser, Thr or Tyr).
CC -!- INTERACTION:
CC Q3MIX3; Q7Z3S9: NOTCH2NLA; NbExp=4; IntAct=EBI-3923548, EBI-945833;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. ADCK protein
CC kinase family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH31570.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK092773; BAG52608.1; -; mRNA.
DR EMBL; AC233992; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC031570; AAH31570.1; ALT_INIT; mRNA.
DR EMBL; BC064345; AAH64345.1; -; mRNA.
DR EMBL; BC085013; AAH85013.1; -; mRNA.
DR EMBL; BC101659; AAI01660.1; -; mRNA.
DR CCDS; CCDS34965.2; -.
DR RefSeq; NP_777582.4; NM_174922.4.
DR AlphaFoldDB; Q3MIX3; -.
DR SMR; Q3MIX3; -.
DR BioGRID; 128442; 17.
DR IntAct; Q3MIX3; 31.
DR MINT; Q3MIX3; -.
DR STRING; 9606.ENSP00000310547; -.
DR ChEMBL; CHEMBL4105886; -.
DR iPTMnet; Q3MIX3; -.
DR PhosphoSitePlus; Q3MIX3; -.
DR BioMuta; ADCK5; -.
DR DMDM; 121958055; -.
DR EPD; Q3MIX3; -.
DR jPOST; Q3MIX3; -.
DR MassIVE; Q3MIX3; -.
DR PaxDb; Q3MIX3; -.
DR PeptideAtlas; Q3MIX3; -.
DR PRIDE; Q3MIX3; -.
DR ProteomicsDB; 61799; -.
DR Antibodypedia; 28478; 190 antibodies from 31 providers.
DR DNASU; 203054; -.
DR Ensembl; ENST00000308860.11; ENSP00000310547.6; ENSG00000173137.12.
DR Ensembl; ENST00000645968.2; ENSP00000494807.1; ENSG00000285451.2.
DR GeneID; 203054; -.
DR KEGG; hsa:203054; -.
DR MANE-Select; ENST00000308860.11; ENSP00000310547.6; NM_174922.5; NP_777582.4.
DR UCSC; uc003zch.5; human.
DR CTD; 203054; -.
DR GeneCards; ADCK5; -.
DR HGNC; HGNC:21738; ADCK5.
DR HPA; ENSG00000173137; Low tissue specificity.
DR neXtProt; NX_Q3MIX3; -.
DR OpenTargets; ENSG00000173137; -.
DR PharmGKB; PA134963849; -.
DR VEuPathDB; HostDB:ENSG00000173137; -.
DR eggNOG; KOG1235; Eukaryota.
DR GeneTree; ENSGT00940000159821; -.
DR HOGENOM; CLU_006533_2_6_1; -.
DR InParanoid; Q3MIX3; -.
DR OMA; RPWRGGW; -.
DR OrthoDB; 790106at2759; -.
DR PhylomeDB; Q3MIX3; -.
DR TreeFam; TF354300; -.
DR PathwayCommons; Q3MIX3; -.
DR SignaLink; Q3MIX3; -.
DR SIGNOR; Q3MIX3; -.
DR BioGRID-ORCS; 203054; 14 hits in 1112 CRISPR screens.
DR ChiTaRS; ADCK5; human.
DR GenomeRNAi; 203054; -.
DR Pharos; Q3MIX3; Tdark.
DR PRO; PR:Q3MIX3; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q3MIX3; protein.
DR Bgee; ENSG00000173137; Expressed in mucosa of transverse colon and 94 other tissues.
DR ExpressionAtlas; Q3MIX3; baseline and differential.
DR Genevisible; Q3MIX3; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd13969; ADCK1-like; 1.
DR InterPro; IPR004147; ABC1_dom.
DR InterPro; IPR045307; ADCK1_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR Pfam; PF03109; ABC1; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
PE 1: Evidence at protein level;
KW Kinase; Membrane; Reference proteome; Serine/threonine-protein kinase;
KW Transferase; Transmembrane; Transmembrane helix.
FT CHAIN 1..580
FT /note="Uncharacterized aarF domain-containing protein
FT kinase 5"
FT /id="PRO_0000271800"
FT TRANSMEM 50..67
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 179..419
FT /note="Protein kinase"
FT VARIANT 17
FT /note="S -> R (in dbSNP:rs6599528)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_029996"
FT CONFLICT 275
FT /note="E -> G (in Ref. 1; BAG52608)"
FT /evidence="ECO:0000305"
FT CONFLICT 283
FT /note="R -> G (in Ref. 3; AAH85013)"
FT /evidence="ECO:0000305"
FT CONFLICT 324..338
FT /note="NDVEAIRSQGLAVHD -> GGLVLCPLQCLSSPQ (in Ref. 3;
FT AAH64345)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 580 AA; 65828 MW; ACA0DB28B7B16F0C CRC64;
MWRPVQLCHF HSALLHSRQK PWPSPAVFFR RNVRGLPPRF SSPTPLWRKV LSTAVVGAPL
LLGARYVMAE AREKRRMRLV VDGMGRFGRS LKVGLQISLD YWWCTNVVLR GVEENSPGYL
EVMSACHQRA ADALVAGAIS NGGLYVKLGQ GLCSFNHLLP PEYTRTLRVL EDRALKRGFQ
EVDELFLEDF QALPHELFQE FDYQPIAAAS LAQVHRAKLH DGTSVAVKVQ YIDLRDRFDG
DIHTLELLLR LVEVMHPSFG FSWVLQDLKG TLAQELDFEN EGRNAERCAR ELAHFPYVVV
PRVHWDKSSK RVLTADFCAG CKVNDVEAIR SQGLAVHDIA EKLIKAFAEQ IFYTGFIHSD
PHPGNVLVRK GPDGKAELVL LDHGLYQFLE EKDRAALCQL WRAIILRDDA AMRAHAAALG
VQDYLLFAEM LMQRPVRLGQ LWGSHLLSRE EAAYMVDMAR ERFEAVMAVL RELPRPMLLV
LRNINTVRAI NVALGAPVDR YFLMAKRAVR GWSRLAGATY RGVYGTSLLR HAKVVWEMLK
FEVALRLETL AMRLTALLAR ALVHLSLVPP AEELYQYLET
