ADCK5_MOUSE
ID ADCK5_MOUSE Reviewed; 582 AA.
AC Q80V03; Q8CAA3;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Uncharacterized aarF domain-containing protein kinase 5;
DE EC=2.7.11.-;
GN Name=Adck5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Hypothalamus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Brain, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: The function of this protein is not yet clear. It is not
CC known if it has protein kinase activity and what type of substrate it
CC would phosphorylate (Ser, Thr or Tyr).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q80V03-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q80V03-2; Sequence=VSP_022358;
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. ADCK protein
CC kinase family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BC030881; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
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DR EMBL; AK039217; BAC30280.1; -; mRNA.
DR EMBL; AC157566; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC030881; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC060528; AAH60528.1; -; mRNA.
DR CCDS; CCDS27576.2; -. [Q80V03-1]
DR RefSeq; NP_766548.2; NM_172960.3.
DR AlphaFoldDB; Q80V03; -.
DR SMR; Q80V03; -.
DR BioGRID; 234564; 1.
DR STRING; 10090.ENSMUSP00000125055; -.
DR iPTMnet; Q80V03; -.
DR PhosphoSitePlus; Q80V03; -.
DR jPOST; Q80V03; -.
DR MaxQB; Q80V03; -.
DR PaxDb; Q80V03; -.
DR PRIDE; Q80V03; -.
DR ProteomicsDB; 285679; -. [Q80V03-1]
DR ProteomicsDB; 285680; -. [Q80V03-2]
DR DNASU; 268822; -.
DR GeneID; 268822; -.
DR KEGG; mmu:268822; -.
DR CTD; 203054; -.
DR MGI; MGI:2679274; Adck5.
DR eggNOG; KOG1235; Eukaryota.
DR InParanoid; Q80V03; -.
DR OrthoDB; 790106at2759; -.
DR PhylomeDB; Q80V03; -.
DR BioGRID-ORCS; 268822; 3 hits in 75 CRISPR screens.
DR ChiTaRS; Adck5; mouse.
DR PRO; PR:Q80V03; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q80V03; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd13969; ADCK1-like; 1.
DR InterPro; IPR004147; ABC1_dom.
DR InterPro; IPR045307; ADCK1_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR Pfam; PF03109; ABC1; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Kinase; Membrane; Reference proteome;
KW Serine/threonine-protein kinase; Transferase; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..582
FT /note="Uncharacterized aarF domain-containing protein
FT kinase 5"
FT /id="PRO_0000271801"
FT TRANSMEM 50..69
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 179..419
FT /note="Protein kinase"
FT VAR_SEQ 1..122
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_022358"
FT CONFLICT 133
FT /note="A -> T (in Ref. 1; BAC30280 and 3; AAH60528)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 582 AA; 66654 MW; 25F612441852B706 CRC64;
MWRPMRLCHF HSTLLQSRQK PWPCPAIFFR RNFKSPPART SRARLLWRRA LSATVVGTPF
LLGAYYFMAE ASERRKLRLA VDGIGRFGRS VKIGLFISTD YWWCTNVVLR GVEENSPKYV
EIMSACHQRA ADALVAGAIR NGGLYVKLGQ GLCSFNHLLP TEYIQTLRVL EDKALTRGFR
EVDELFLEDF QALPNELFQE FDYEPMAAAS LAQVHRAKLH DGTDVAVKVQ YIDLRDRFDG
DVQTLELLLR LVELMHPSFG FSWVLQDLKG TLVQELDFEN EGRNAERCAQ ELKHFHYVVI
PRVHWDRSSK RVLTADFCNG CKVNDMEGIK SQGLAVQDVA KKLIQTFAEQ IFHTGFIHSD
PHPGNVLVRK GPDGKAELVL LDHGLYQFLD EKDRSSLCQL WRAIILRDNA AMKKHAAALG
VQDYMLFSEV LMQRPVRLGQ LWGSHLISRE EAAYMQDMAR EHFDGIMEVL KALPRPMLLV
LRNINTVRAI NSNLGTPVDR YFLMAKSAVW GWSRLVGAAY QGIYGSSLLR HIKVLWEALK
FEMALRLEIL AMRLTALMLR VLVRLGFAPK AEAEEVYQYL EM
