ID   DIUH1_MANSE             Reviewed;         138 AA.
AC   P21819;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 2.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Diuretic hormone 1;
DE            Short=DH-1;
DE   AltName: Full=Diuretic peptide 1;
DE            Short=DP-1;
DE   AltName: Full=Mas-DH;
DE   Flags: Precursor;
OS   Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Sphingidae; Sphinginae; Sphingini; Manduca.
OX   NCBI_TaxID=7130;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1279702; DOI=10.1073/pnas.89.22.11074;
RA   Digan M.E., Roberts D.N., Enderlin F.E., Woodworth A.R., Kramer S.J.;
RT   "Characterization of the precursor for Manduca sexta diuretic hormone Mas-
RT   DH.";
RL   Proc. Natl. Acad. Sci. U.S.A. 89:11074-11078(1992).
RN   [2]
RP   PROTEIN SEQUENCE OF 81-121, AND AMIDATION AT ILE-121.
RC   TISSUE=Corpora cardiaca;
RX   PubMed=16594029; DOI=10.1073/pnas.86.8.2976;
RA   Kataoka H., Troetschler R.G., Li J.P., Kramer S.J., Carney R.L.,
RA   Schooley D.A.;
RT   "Isolation and identification of a diuretic hormone from the tobacco
RT   hornworm, Manduca sexta.";
RL   Proc. Natl. Acad. Sci. U.S.A. 86:2976-2980(1989).
CC   -!- FUNCTION: Regulation of fluid secretion.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the sauvagine/corticotropin-releasing
CC       factor/urotensin I family. {ECO:0000305}.
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DR   EMBL; L04628; AAB59200.1; -; mRNA.
DR   PIR; A46377; SWWOD.
DR   AlphaFoldDB; P21819; -.
DR   SMR; P21819; -.
DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0008613; F:diuretic hormone activity; IDA:UniProtKB.
DR   GO; GO:0007589; P:body fluid secretion; IDA:UniProtKB.
DR   InterPro; IPR018446; Corticotropin-releasing_fac_CS.
DR   InterPro; IPR000187; CRF.
DR   Pfam; PF00473; CRF; 1.
DR   SMART; SM00039; CRF; 1.
DR   PROSITE; PS00511; CRF; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Hormone; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..78
FT                   /id="PRO_0000006230"
FT   PEPTIDE         81..121
FT                   /note="Diuretic hormone 1"
FT                   /id="PRO_0000006231"
FT   PROPEP          125..138
FT                   /id="PRO_0000006232"
FT   MOD_RES         121
FT                   /note="Isoleucine amide"
FT                   /evidence="ECO:0000269|PubMed:16594029"
SQ   SEQUENCE   138 AA;  15297 MW;  EE615B771BCD2CE0 CRC64;
     MMWWAIWCVM VVVSSAASAA PAPDSAPMDL VQIDSAGPDD ESLGYAVSSL EGRYGAEAPW
     LYLLAEMPRD SQIGRAAVKR RMPSLSIDLP MSVLRQKLSL EKERKVHALR AAANRNFLND
     IGKRGLQWSR SEQPSAYY