ID   DIUH1_TENMO             Reviewed;          37 AA.
AC   P56618;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-1998, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Diuretic hormone 1;
DE   AltName: Full=DH(37);
DE            Short=DH37;
DE   AltName: Full=Diuretic hormone I;
DE            Short=DH I;
DE   AltName: Full=Diuretic peptide I;
DE            Short=DP I;
OS   Tenebrio molitor (Yellow mealworm beetle).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC   Tenebrionidae; Tenebrio.
OX   NCBI_TaxID=7067;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Head;
RX   PubMed=8618894; DOI=10.1073/pnas.92.26.12323;
RA   Furuya K., Schegg K.M., Wang H., King D.S., Schooley D.A.;
RT   "Isolation and identification of a diuretic hormone from the mealworm
RT   Tenebrio molitor.";
RL   Proc. Natl. Acad. Sci. U.S.A. 92:12323-12327(1995).
RN   [2]
RP   FUNCTION.
RX   PubMed=11893763; DOI=10.1242/jeb.205.4.493;
RA   Wiehart U.I.M., Nicolson S.W., Eigenheer R.A., Schooley D.A.;
RT   "Antagonistic control of fluid secretion by the Malpighian tubules of
RT   Tenebrio molitor: effects of diuretic and antidiuretic peptides and their
RT   second messengers.";
RL   J. Exp. Biol. 205:493-501(2002).
CC   -!- FUNCTION: Stimulates fluid secretion by the Malpighian tubules.
CC       Increases cyclic AMP production. {ECO:0000269|PubMed:11893763}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- MISCELLANEOUS: Inhibited by antidiuretic factor A.
CC   -!- SIMILARITY: Belongs to the sauvagine/corticotropin-releasing
CC       factor/urotensin I family. {ECO:0000305}.
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DR   PIR; A58607; A57127.
DR   AlphaFoldDB; P56618; -.
DR   SMR; P56618; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR018446; Corticotropin-releasing_fac_CS.
DR   InterPro; IPR000187; CRF.
DR   Pfam; PF00473; CRF; 1.
DR   PROSITE; PS00511; CRF; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hormone; Secreted.
FT   PEPTIDE         1..37
FT                   /note="Diuretic hormone 1"
FT                   /id="PRO_0000044692"
SQ   SEQUENCE   37 AA;  4371 MW;  519EC232D3473A85 CRC64;
     SPTISITAPI DVLRKTWEQE RARKQMVKNR EFLNSLN