ID   DIUH2_HYLLI             Reviewed;          30 AA.
AC   P82015;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Diuretic hormone 2;
DE            Short=DH-2;
DE   AltName: Full=DH(30);
DE   AltName: Full=Diuretic peptide 2;
DE            Short=DP-2;
OS   Hyles lineata (White-lined sphinx moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Sphingidae; Macroglossinae; Macroglossini; Hyles.
OX   NCBI_TaxID=103890;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, AMIDATION AT VAL-30, AND MASS SPECTROMETRY.
RC   TISSUE=Head;
RX   PubMed=10696588; DOI=10.1016/s0965-1748(99)00106-x;
RA   Furuya K., Harper M.A., Schegg K.M., Shooley D.A.;
RT   "Isolation and characterization of CRF-related diuretic hormones from the
RT   whitelined sphinx moth Hyles lineata.";
RL   Insect Biochem. Mol. Biol. 30:127-133(2000).
CC   -!- FUNCTION: Regulation of fluid secretion. May stimulate primary urine
CC       secretion by Malpighian tubules and causes a dose-dependent stimulation
CC       of cAMP levels in the tubules. {ECO:0000269|PubMed:10696588}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- MASS SPECTROMETRY: Mass=3574; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:10696588};
CC   -!- SIMILARITY: Belongs to the sauvagine/corticotropin-releasing
CC       factor/urotensin I family. {ECO:0000305}.
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DR   AlphaFoldDB; P82015; -.
DR   SMR; P82015; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR000187; CRF.
DR   SMART; SM00039; CRF; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Secreted.
FT   PEPTIDE         1..30
FT                   /note="Diuretic hormone 2"
FT                   /id="PRO_0000043598"
FT   MOD_RES         30
FT                   /note="Valine amide"
FT                   /evidence="ECO:0000269|PubMed:10696588"
SQ   SEQUENCE   30 AA;  3575 MW;  5C2D6BD2DD8BFC67 CRC64;
     SFSVNPAVEI LQHRYMEKVA QNNRNFLNRV