ID   DIUH2_TENMO             Reviewed;          47 AA.
AC   P56619;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-1998, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Diuretic hormone 2;
DE   AltName: Full=DH(47);
DE            Short=DH47;
DE   AltName: Full=Diuretic hormone II;
DE            Short=DH II;
DE   AltName: Full=Diuretic peptide II;
DE            Short=DP II;
OS   Tenebrio molitor (Yellow mealworm beetle).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC   Tenebrionidae; Tenebrio.
OX   NCBI_TaxID=7067;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Head;
RX   PubMed=9622015; DOI=10.1016/s0196-9781(97)00475-0;
RA   Furuya K., Schegg K.M., Schooley D.A.;
RT   "Isolation and identification of a second diuretic hormone from Tenebrio
RT   molitor.";
RL   Peptides 19:619-626(1998).
CC   -!- FUNCTION: Stimulates fluid secretion by the Malpighian tubules.
CC       Increases cyclic AMP production in Malpighian tubules.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the sauvagine/corticotropin-releasing
CC       factor/urotensin I family. {ECO:0000305}.
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DR   PIR; A59009; A59009.
DR   AlphaFoldDB; P56619; -.
DR   SMR; P56619; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR018446; Corticotropin-releasing_fac_CS.
DR   InterPro; IPR000187; CRF.
DR   Pfam; PF00473; CRF; 1.
DR   SMART; SM00039; CRF; 1.
DR   PROSITE; PS00511; CRF; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hormone; Secreted.
FT   CHAIN           1..47
FT                   /note="Diuretic hormone 2"
FT                   /id="PRO_0000221022"
SQ   SEQUENCE   47 AA;  5030 MW;  9176E090AB1B803A CRC64;
     AGALGESGAS LSIVNSLDVL RNRLLLEIAR KKAKEGANRN RQILLSL