ID   DIUH_ACHDO              Reviewed;          46 AA.
AC   P23834;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Diuretic hormone;
DE            Short=DH;
DE   AltName: Full=Diuretic peptide;
DE            Short=DP;
OS   Acheta domesticus (House cricket).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Polyneoptera; Orthoptera; Ensifera; Gryllidea; Grylloidea;
OC   Gryllidae; Gryllinae; Acheta.
OX   NCBI_TaxID=6997;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT ILE-46.
RX   PubMed=1657035; DOI=10.1515/bchm3.1991.372.2.505;
RA   Kay I., Coast G.M., Cusinato O., Wheeler C.H., Totty N.F.,
RA   Goldsworthy G.J.;
RT   "Isolation and characterization of a diuretic peptide from Acheta
RT   domesticus. Evidence for a family of insect diuretic peptides.";
RL   Biol. Chem. Hoppe-Seyler 372:505-512(1991).
CC   -!- FUNCTION: Regulation of fluid secretion. Stimulates primary urine
CC       secretion by Malpighian tubules and causes a dose-dependent stimulation
CC       of cAMP levels in the tubules.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the sauvagine/corticotropin-releasing
CC       factor/urotensin I family. {ECO:0000305}.
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DR   PIR; S16198; S16198.
DR   AlphaFoldDB; P23834; -.
DR   SMR; P23834; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR018446; Corticotropin-releasing_fac_CS.
DR   InterPro; IPR000187; CRF.
DR   Pfam; PF00473; CRF; 1.
DR   SMART; SM00039; CRF; 1.
DR   PROSITE; PS00511; CRF; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Secreted.
FT   CHAIN           1..46
FT                   /note="Diuretic hormone"
FT                   /id="PRO_0000221016"
FT   MOD_RES         46
FT                   /note="Isoleucine amide"
FT                   /evidence="ECO:0000269|PubMed:1657035"
SQ   SEQUENCE   46 AA;  5361 MW;  072CB6C493EFFCE4 CRC64;
     TGAQSLSIVA PLDVLRQRLM NELNRRRMRE LQGSRIQQNR QLLTSI