ID   DIUH_DIPPU              Reviewed;          46 AA.
AC   P82373;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Diuretic hormone class 1;
DE   AltName: Full=DH(46);
DE   AltName: Full=Diuretic hormone class I;
DE   AltName: Full=Diuretic peptide;
DE            Short=DP;
OS   Diploptera punctata (Pacific beetle cockroach).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blaberoidea; Blaberidae;
OC   Diplopterinae; Diploptera.
OX   NCBI_TaxID=6984;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, AMIDATION AT ILE-46, AND MASS SPECTROMETRY.
RC   TISSUE=Brain, and Corpora cardiaca;
RX   PubMed=10841553; DOI=10.1073/pnas.97.12.6469;
RA   Furuya K., Milchak R.J., Schegg K.M., Zhang J., Tobe S.S., Coast G.M.,
RA   Schooley D.A.;
RT   "Cockroach diuretic hormones: characterization of a calcitonin-like peptide
RT   in insects.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:6469-6474(2000).
CC   -!- FUNCTION: Regulation of fluid secretion. Stimulates primary urine
CC       secretion by Malpighian tubules and causes a dose-dependent stimulation
CC       of cAMP levels in the tubules. Has a greater effect on the transport of
CC       Na(+) then K(+) ions. In vitro, has synergistic effects with the
CC       smaller diuretic hormone DH(31) which co-occurs with it.
CC       {ECO:0000269|PubMed:10841553}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- MASS SPECTROMETRY: Mass=5322; Mass_error=0.1; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:10841553};
CC   -!- SIMILARITY: Belongs to the sauvagine/corticotropin-releasing
CC       factor/urotensin I family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; P82373; -.
DR   SMR; P82373; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR018446; Corticotropin-releasing_fac_CS.
DR   InterPro; IPR000187; CRF.
DR   Pfam; PF00473; CRF; 1.
DR   SMART; SM00039; CRF; 1.
DR   PROSITE; PS00511; CRF; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Secreted.
FT   CHAIN           1..46
FT                   /note="Diuretic hormone class 1"
FT                   /id="PRO_0000221017"
FT   MOD_RES         46
FT                   /note="Isoleucine amide"
FT                   /evidence="ECO:0000269|PubMed:10841553"
SQ   SEQUENCE   46 AA;  5322 MW;  693CD9A16E47F67E CRC64;
     TGTGPSLSIV NPLDVLRQRL LLEIARRRMR QTQNMIQANR DFLESI