ID   DIUH_LOCMI              Reviewed;          46 AA.
AC   P23465;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Diuretic hormone;
DE            Short=DH;
DE   AltName: Full=Diuretic peptide;
DE            Short=DP;
OS   Locusta migratoria (Migratory locust).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Polyneoptera; Orthoptera; Caelifera; Acrididea; Acridomorpha;
OC   Acridoidea; Acrididae; Oedipodinae; Locusta.
OX   NCBI_TaxID=7004;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Brain;
RX   PubMed=1654896; DOI=10.1016/0006-291x(91)91923-z;
RA   Lehmberg E., Ota R.B., Furuya K., King D.S., Applebaum S.W., Ferenz H.-J.,
RA   Schooly D.A.;
RT   "Identification of a diuretic hormone of Locusta migratoria.";
RL   Biochem. Biophys. Res. Commun. 179:1036-1041(1991).
RN   [2]
RP   PROTEIN SEQUENCE, AND AMIDATION AT ILE-46.
RC   TISSUE=Malpighian tubule;
RX   PubMed=1663363; DOI=10.1515/bchm3.1991.372.2.929;
RA   Kay I., Wheeler C.H., Coast G.M., Totty N.F., Cusinato O., Patel M.,
RA   Goldsworthy G.J.;
RT   "Characterization of a diuretic peptide from Locusta migratoria.";
RL   Biol. Chem. Hoppe-Seyler 372:929-934(1991).
CC   -!- FUNCTION: Regulation of fluid secretion. Stimulates primary urine
CC       secretion by Malpighian tubules and causes a dose-dependent stimulation
CC       of cAMP levels in the tubules.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the sauvagine/corticotropin-releasing
CC       factor/urotensin I family. {ECO:0000305}.
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DR   PIR; JH0243; SWLQDA.
DR   AlphaFoldDB; P23465; -.
DR   SMR; P23465; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR018446; Corticotropin-releasing_fac_CS.
DR   InterPro; IPR000187; CRF.
DR   Pfam; PF00473; CRF; 1.
DR   SMART; SM00039; CRF; 1.
DR   PROSITE; PS00511; CRF; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Secreted.
FT   CHAIN           1..46
FT                   /note="Diuretic hormone"
FT                   /id="PRO_0000221015"
FT   MOD_RES         46
FT                   /note="Isoleucine amide"
FT                   /evidence="ECO:0000269|PubMed:1663363"
SQ   SEQUENCE   46 AA;  5364 MW;  E063260E74939763 CRC64;
     MGMGPSLSIV NPMDVLRQRL LLEIARRRLR DAEEQIKANK DFLQQI