ID   DIUH_MUSDO              Reviewed;          44 AA.
AC   P67800; P41537;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=Diuretic hormone;
DE            Short=DH;
DE   AltName: Full=Diuretic peptide {ECO:0000303|PubMed:7991460};
DE            Short=DP {ECO:0000303|PubMed:7991460};
OS   Musca domestica (House fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC   Muscidae; Musca.
OX   NCBI_TaxID=7370;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, MASS SPECTROMETRY, AND AMIDATION AT VAL-44.
RX   PubMed=7991460; DOI=10.1016/0196-9781(94)90059-0;
RA   Clottens F.L., Holman G.M., Coast G.M., Totty N.F., Hayes T.K., Kay I.,
RA   Mallet A.I., Wright M.S., Chung J.-S., Truong O., Bull D.L.;
RT   "Isolation and characterization of a diuretic peptide common to the house
RT   fly and stable fly.";
RL   Peptides 15:971-979(1994).
CC   -!- FUNCTION: Regulation of fluid secretion. Stimulates primary urine
CC       secretion by Malpighian tubules and causes a dose-dependent stimulation
CC       of cAMP levels in the tubules. May act as clearance peptide in that it
CC       may remove metabolic waste from the hemolymph.
CC       {ECO:0000269|PubMed:7991460}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- MASS SPECTROMETRY: Mass=5196; Mass_error=4; Method=Electrospray;
CC       Note=Met-27 oxidized during isolation.;
CC       Evidence={ECO:0000269|PubMed:7991460};
CC   -!- SIMILARITY: Belongs to the sauvagine/corticotropin-releasing
CC       factor/urotensin I family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; P67800; -.
DR   SMR; P67800; -.
DR   STRING; 7370.XP_005175260.1; -.
DR   VEuPathDB; VectorBase:MDOA001455; -.
DR   eggNOG; ENOG502SCPI; Eukaryota.
DR   Proteomes; UP000095301; Whole Genome Shotgun Assembly.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR018446; Corticotropin-releasing_fac_CS.
DR   InterPro; IPR000187; CRF.
DR   Pfam; PF00473; CRF; 1.
DR   SMART; SM00039; CRF; 1.
DR   PROSITE; PS00511; CRF; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Secreted.
FT   CHAIN           1..44
FT                   /note="Diuretic hormone"
FT                   /evidence="ECO:0000269|PubMed:7991460"
FT                   /id="PRO_0000221019"
FT   MOD_RES         44
FT                   /note="Valine amide"
FT                   /evidence="ECO:0000269|PubMed:7991460"
SQ   SEQUENCE   44 AA;  5181 MW;  67628086D21487B6 CRC64;
     NKPSLSIVNP LDVLRQRLLL EIARRQMKEN TRQVELNRAI LKNV