ID   DIUH_PERAM              Reviewed;          46 AA.
AC   P41538;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Diuretic hormone;
DE            Short=DH;
DE   AltName: Full=Diuretic peptide;
DE            Short=DP;
OS   Periplaneta americana (American cockroach) (Blatta americana).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blattoidea; Blattidae;
OC   Blattinae; Periplaneta.
OX   NCBI_TaxID=6978;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT ILE-46.
RX   PubMed=1337794; DOI=10.1016/0167-0115(92)90091-8;
RA   Kay I., Patel M., Coast G.M., Totty N.F., Mallet A.I., Goldsworthy G.J.;
RT   "Isolation, characterization and biological activity of a CRF-related
RT   diuretic peptide from Periplaneta americana L.";
RL   Regul. Pept. 42:111-122(1992).
CC   -!- FUNCTION: Regulation of fluid secretion. Stimulates primary urine
CC       secretion by Malpighian tubules and causes a dose-dependent stimulation
CC       of cAMP levels in the tubules.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the sauvagine/corticotropin-releasing
CC       factor/urotensin I family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   PIR; A48542; A48542.
DR   AlphaFoldDB; P41538; -.
DR   SMR; P41538; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR018446; Corticotropin-releasing_fac_CS.
DR   InterPro; IPR000187; CRF.
DR   Pfam; PF00473; CRF; 1.
DR   SMART; SM00039; CRF; 1.
DR   PROSITE; PS00511; CRF; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Secreted.
FT   CHAIN           1..46
FT                   /note="Diuretic hormone"
FT                   /id="PRO_0000221020"
FT   MOD_RES         46
FT                   /note="Isoleucine amide"
FT                   /evidence="ECO:0000269|PubMed:1337794"
SQ   SEQUENCE   46 AA;  5285 MW;  6938D47CB5AF2BA5 CRC64;
     TGSGPSLSIV NPLDVLRQRL LLEIARRRMR QSQDQIQANR EILQTI