ID   DIUH_ZOONE              Reviewed;          46 AA.
AC   P82707;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   27-APR-2001, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Diuretic hormone;
DE            Short=DH;
DE   AltName: Full=Diuretic peptide;
DE            Short=DP;
OS   Zootermopsis nevadensis (Dampwood termite).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blattoidea; Termitoidae;
OC   Termopsidae; Zootermopsis.
OX   NCBI_TaxID=136037;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, MASS SPECTROMETRY, AND AMIDATION AT ILE-46.
RC   TISSUE=Head;
RX   PubMed=11179807; DOI=10.1016/s0196-9781(00)00371-5;
RA   Baldwin D.C., Schegg K.M., Furuya K., Lehmberg E., Schooley D.A.;
RT   "Isolation and identification of a diuretic hormone from Zootermopsis
RT   nevadensis.";
RL   Peptides 22:147-152(2001).
CC   -!- FUNCTION: Regulation of fluid secretion. Stimulates primary urine
CC       secretion by Malpighian tubules and causes a dose-dependent stimulation
CC       of cAMP levels in the tubules. {ECO:0000269|PubMed:11179807}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- MASS SPECTROMETRY: Mass=5329.0; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:11179807};
CC   -!- SIMILARITY: Belongs to the sauvagine/corticotropin-releasing
CC       factor/urotensin I family. {ECO:0000305}.
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DR   AlphaFoldDB; P82707; -.
DR   SMR; P82707; -.
DR   STRING; 136037.KDR14744; -.
DR   eggNOG; ENOG502SCPI; Eukaryota.
DR   HOGENOM; CLU_1416890_0_0_1; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR018446; Corticotropin-releasing_fac_CS.
DR   InterPro; IPR000187; CRF.
DR   Pfam; PF00473; CRF; 1.
DR   SMART; SM00039; CRF; 1.
DR   PROSITE; PS00511; CRF; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Secreted.
FT   CHAIN           1..46
FT                   /note="Diuretic hormone"
FT                   /id="PRO_0000221023"
FT   MOD_RES         46
FT                   /note="Isoleucine amide"
FT                   /evidence="ECO:0000269|PubMed:11179807"
SQ   SEQUENCE   46 AA;  5329 MW;  6938C02E11F151A5 CRC64;
     TGAVPSLSIV NPLDVLRQRL LLEIARRRMR QSQDQIQANR EMLQTI