ID   DIUX_DIPPU              Reviewed;          31 AA.
AC   P82372;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Diuretic hormone class 2;
DE   AltName: Full=DH(31);
DE   AltName: Full=Diuretic hormone class II;
DE   AltName: Full=Diuretic peptide;
DE            Short=DP;
OS   Diploptera punctata (Pacific beetle cockroach).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blaberoidea; Blaberidae;
OC   Diplopterinae; Diploptera.
OX   NCBI_TaxID=6984;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, AMIDATION AT PRO-31, AND MASS SPECTROMETRY.
RC   TISSUE=Brain, and Corpora cardiaca;
RX   PubMed=10841553; DOI=10.1073/pnas.97.12.6469;
RA   Furuya K., Milchak R.J., Schegg K.M., Zhang J., Tobe S.S., Coast G.M.,
RA   Schooley D.A.;
RT   "Cockroach diuretic hormones: characterization of a calcitonin-like peptide
RT   in insects.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:6469-6474(2000).
CC   -!- FUNCTION: Regulation of fluid secretion. Stimulates primary urine
CC       secretion by Malpighian tubules and causes a dose-dependent stimulation
CC       of cAMP levels in the tubules. Has a nonselective effect on Na(+)/K(+)
CC       ion transport. In vitro, primarily elevates intracellular Ca(2+). Has
CC       synergistic effects with the larger diuretic hormone DH(46) which co-
CC       occurs with it. {ECO:0000269|PubMed:10841553}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- MASS SPECTROMETRY: Mass=2987; Mass_error=0.2; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:10841553};
CC   -!- SIMILARITY: Belongs to the diuretic hormone class 2 family.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P82372; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Secreted.
FT   PEPTIDE         1..31
FT                   /note="Diuretic hormone class 2"
FT                   /id="PRO_0000044694"
FT   MOD_RES         31
FT                   /note="Proline amide"
FT                   /evidence="ECO:0000269|PubMed:10841553"
SQ   SEQUENCE   31 AA;  2988 MW;  0F311E0C3AD71A46 CRC64;
     GLDLGLSRGF SGSQAAKHLM GLAAANYAGG P