DIV35_CARDV
ID DIV35_CARDV Reviewed; 43 AA.
AC P84962;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 1.
DT 25-MAY-2022, entry version 44.
DE RecName: Full=Bacteriocin divergicin M35;
OS Carnobacterium divergens (Lactobacillus divergens).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Carnobacteriaceae;
OC Carnobacterium.
OX NCBI_TaxID=2748;
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, AND MASS SPECTROMETRY.
RC STRAIN=M35 {ECO:0000269|PubMed:15541799};
RX PubMed=15541799; DOI=10.1016/j.ijfoodmicro.2004.04.013;
RA Tahiri I., Desbiens M., Benech R., Kheadr E., Lacroix C., Thibault S.,
RA Ouellet D., Fliss I.;
RT "Purification, characterization and amino acid sequencing of divergicin
RT M35: a novel class IIa bacteriocin produced by Carnobacterium divergens
RT M35.";
RL Int. J. Food Microbiol. 97:123-136(2004).
CC -!- FUNCTION: Bacteriocin with antibacterial activity against many strains
CC of L.monocytogenes, L.seeligeri, L.welshimeri, L.grayi, L.murayi,
CC L.ivanovii, L.innocus, C.divergens and C.piscocola. No antibacterial
CC activity was detected against L.lactis, P.acidilactici, P.pentosaceus,
CC L.salivarius, L.delbruekii, L.acidophilus, L.plantarum, L.casei,
CC L.rhamnosus, S.thermophilus, P.freudenreichii, B.breve and E.coli.
CC {ECO:0000269|PubMed:15541799}.
CC -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC Temperature dependence:
CC Displays a high degree of stability when incubated at temperatures of
CC up to 121 degrees Celsius for 60 minutes.
CC {ECO:0000269|PubMed:15541799};
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15541799}.
CC -!- MASS SPECTROMETRY: Mass=4518.75; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:15541799};
CC -!- BIOTECHNOLOGY: Has potential for use as a biopreservative for
CC inhibiting L.monocytogenes in seafood products that do not usually
CC undergo an adequate heat treatment. {ECO:0000269|PubMed:15541799}.
CC -!- SIMILARITY: Belongs to the bacteriocin class IIA/YGNGV family.
CC {ECO:0000255}.
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DR AlphaFoldDB; P84962; -.
DR TCDB; 1.C.24.1.13; the pediocin (pediocin) family.
DR GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB.
DR Gene3D; 1.20.5.130; -; 1.
DR InterPro; IPR002633; Bacteriocin_IIa.
DR InterPro; IPR023384; Bacteriocin_IIa_CS.
DR InterPro; IPR023388; Bacteriocin_IIa_dom_sf.
DR Pfam; PF01721; Bacteriocin_II; 1.
DR PROSITE; PS60030; BACTERIOCIN_IIA; 1.
PE 1: Evidence at protein level;
KW Antibiotic; Antimicrobial; Bacteriocin; Direct protein sequencing;
KW Secreted.
FT PEPTIDE 1..43
FT /note="Bacteriocin divergicin M35"
FT /id="PRO_0000250606"
SQ SEQUENCE 43 AA; 4525 MW; 3370AC1734B4DF55 CRC64;
TKYYGNGVYC NSKKCWVDWG TAQGCIDVVI GQLGGGIPGK GKC