ADCL3_HUMAN
ID ADCL3_HUMAN Reviewed; 407 AA.
AC Q5VUY0; B3KXR9; Q5VUY1;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 28-MAR-2018, sequence version 5.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Arylacetamide deacetylase-like 3;
DE EC=3.1.1.-;
GN Name=AADACL3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
CC -!- SIMILARITY: Belongs to the 'GDXG' lipolytic enzyme family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAG54581.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};
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DR EMBL; AK127828; BAG54581.1; ALT_SEQ; mRNA.
DR EMBL; AC244670; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS41253.2; -.
DR RefSeq; NP_001096640.2; NM_001103170.2.
DR AlphaFoldDB; Q5VUY0; -.
DR SMR; Q5VUY0; -.
DR STRING; 9606.ENSP00000352268; -.
DR ESTHER; human-AADACL3; Arylacetamide_deacetylase.
DR iPTMnet; Q5VUY0; -.
DR PhosphoSitePlus; Q5VUY0; -.
DR BioMuta; AADACL3; -.
DR DMDM; 317373552; -.
DR PaxDb; Q5VUY0; -.
DR PRIDE; Q5VUY0; -.
DR Antibodypedia; 57582; 48 antibodies from 11 providers.
DR DNASU; 126767; -.
DR Ensembl; ENST00000359318.8; ENSP00000352268.6; ENSG00000188984.12.
DR GeneID; 126767; -.
DR KEGG; hsa:126767; -.
DR MANE-Select; ENST00000359318.8; ENSP00000352268.6; NM_001103170.3; NP_001096640.2.
DR UCSC; uc057ckc.1; human.
DR CTD; 126767; -.
DR GeneCards; AADACL3; -.
DR HGNC; HGNC:32037; AADACL3.
DR HPA; ENSG00000188984; Tissue enhanced (placenta, skin).
DR neXtProt; NX_Q5VUY0; -.
DR OpenTargets; ENSG00000188984; -.
DR PharmGKB; PA145147526; -.
DR VEuPathDB; HostDB:ENSG00000188984; -.
DR eggNOG; KOG1515; Eukaryota.
DR GeneTree; ENSGT00940000162160; -.
DR HOGENOM; CLU_012494_12_2_1; -.
DR InParanoid; Q5VUY0; -.
DR OMA; TCIVSCE; -.
DR OrthoDB; 1263520at2759; -.
DR PhylomeDB; Q5VUY0; -.
DR TreeFam; TF314978; -.
DR PathwayCommons; Q5VUY0; -.
DR SABIO-RK; Q5VUY0; -.
DR BioGRID-ORCS; 126767; 11 hits in 1062 CRISPR screens.
DR GeneWiki; AADACL3_(gene); -.
DR GenomeRNAi; 126767; -.
DR Pharos; Q5VUY0; Tdark.
DR PRO; PR:Q5VUY0; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5VUY0; protein.
DR Bgee; ENSG00000188984; Expressed in placenta and 8 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
DR GO; GO:0052689; F:carboxylic ester hydrolase activity; IEA:InterPro.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR013094; AB_hydrolase_3.
DR InterPro; IPR017157; Arylacetamide_deacetylase.
DR Pfam; PF07859; Abhydrolase_3; 2.
DR PIRSF; PIRSF037251; Arylacetamide_deacetylase; 1.
DR SUPFAM; SSF53474; SSF53474; 1.
PE 2: Evidence at transcript level;
KW Hydrolase; Reference proteome.
FT CHAIN 1..407
FT /note="Arylacetamide deacetylase-like 3"
FT /id="PRO_0000265936"
FT MOTIF 119..121
FT /note="Involved in the stabilization of the negatively
FT charged intermediate by the formation of the oxyanion hole"
FT /evidence="ECO:0000250|UniProtKB:Q5NUF3"
FT ACT_SITE 193
FT /evidence="ECO:0000250|UniProtKB:Q8BLF1"
FT ACT_SITE 347
FT /evidence="ECO:0000250|UniProtKB:Q8BLF1"
FT ACT_SITE 377
FT /evidence="ECO:0000250|UniProtKB:Q8BLF1"
FT VARIANT 104
FT /note="P -> S (in dbSNP:rs3010877)"
FT /id="VAR_060666"
FT VARIANT 128
FT /note="L -> M (in dbSNP:rs3000859)"
FT /id="VAR_060667"
FT VARIANT 186
FT /note="R -> W (in dbSNP:rs17038445)"
FT /id="VAR_060668"
FT VARIANT 252
FT /note="F -> C (in dbSNP:rs7513079)"
FT /id="VAR_060665"
FT VARIANT 307
FT /note="M -> I (in dbSNP:rs3000931)"
FT /id="VAR_060670"
FT VARIANT 337
FT /note="P -> L (in dbSNP:rs11121969)"
FT /id="VAR_060671"
SQ SEQUENCE 407 AA; 46155 MW; 0BAB3056EEED2B19 CRC64;
MWDLALIFLA AACVFSLGVT LWVICSHFFT VHIPAAVGHP VKLRVLHCIF QLLLTWGMIF
EKLRICSMPQ FFCFMQDLPP LKYDPDVVVT DFRFGTIPVK LYQPKASTCT LKPGIVYYHG
GGGVMGSLKT HHGICSRLCK ESDSVVLAVG YRKLPKHKFP VPVRDCLVAT IHFLKSLDAY
GVDPARVVVC GDSFGGAIAA VVCQQLVDRP DLPRIRAQIL IYAILQALDL QTPSFQQRKN
IPLLTWSFIC YFFFQNLDFS SSWQEVIMKG AHLPAEVWEK YRKWLGPENI PERFKERGYQ
LKPHEPMNEA AYLEVSVVLD VMCSPLIAED DIVSQLPETC IVSCEYDALR DNSLLYKKRL
EDLGVPVTWH HMEDGFHGVL RTIDMSFLHF PCSMRILSAL VQFVKGL
