ADCL4_HUMAN
ID ADCL4_HUMAN Reviewed; 407 AA.
AC Q5VUY2;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Arylacetamide deacetylase-like 4;
DE EC=3.1.1.-;
GN Name=AADACL4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the 'GDXG' lipolytic enzyme family.
CC {ECO:0000305}.
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DR EMBL; AL513016; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS30590.1; -.
DR RefSeq; NP_001013652.1; NM_001013630.1.
DR AlphaFoldDB; Q5VUY2; -.
DR SMR; Q5VUY2; -.
DR IntAct; Q5VUY2; 1.
DR STRING; 9606.ENSP00000365395; -.
DR ESTHER; human-AADACL4; Arylacetamide_deacetylase.
DR GlyGen; Q5VUY2; 2 sites.
DR iPTMnet; Q5VUY2; -.
DR PhosphoSitePlus; Q5VUY2; -.
DR BioMuta; AADACL4; -.
DR DMDM; 74747169; -.
DR PaxDb; Q5VUY2; -.
DR PeptideAtlas; Q5VUY2; -.
DR PRIDE; Q5VUY2; -.
DR ProteomicsDB; 65430; -.
DR Antibodypedia; 46608; 98 antibodies from 19 providers.
DR DNASU; 343066; -.
DR Ensembl; ENST00000376221.2; ENSP00000365395.1; ENSG00000204518.3.
DR GeneID; 343066; -.
DR KEGG; hsa:343066; -.
DR MANE-Select; ENST00000376221.2; ENSP00000365395.1; NM_001013630.2; NP_001013652.1.
DR UCSC; uc001auf.3; human.
DR CTD; 343066; -.
DR GeneCards; AADACL4; -.
DR HGNC; HGNC:32038; AADACL4.
DR HPA; ENSG00000204518; Not detected.
DR neXtProt; NX_Q5VUY2; -.
DR OpenTargets; ENSG00000204518; -.
DR PharmGKB; PA145147537; -.
DR VEuPathDB; HostDB:ENSG00000204518; -.
DR eggNOG; KOG1515; Eukaryota.
DR GeneTree; ENSGT00940000157630; -.
DR HOGENOM; CLU_012494_12_2_1; -.
DR InParanoid; Q5VUY2; -.
DR OMA; VCRHIAK; -.
DR OrthoDB; 1263520at2759; -.
DR PhylomeDB; Q5VUY2; -.
DR TreeFam; TF314978; -.
DR PathwayCommons; Q5VUY2; -.
DR SignaLink; Q5VUY2; -.
DR BioGRID-ORCS; 343066; 7 hits in 1062 CRISPR screens.
DR GeneWiki; AADACL4_(gene); -.
DR GenomeRNAi; 343066; -.
DR Pharos; Q5VUY2; Tdark.
DR PRO; PR:Q5VUY2; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5VUY2; protein.
DR Bgee; ENSG00000204518; Expressed in omental fat pad and 34 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0052689; F:carboxylic ester hydrolase activity; IEA:InterPro.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR013094; AB_hydrolase_3.
DR InterPro; IPR017157; Arylacetamide_deacetylase.
DR Pfam; PF07859; Abhydrolase_3; 2.
DR PIRSF; PIRSF037251; Arylacetamide_deacetylase; 1.
DR SUPFAM; SSF53474; SSF53474; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Hydrolase; Membrane; Reference proteome; Signal-anchor;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..407
FT /note="Arylacetamide deacetylase-like 4"
FT /id="PRO_0000265937"
FT TOPO_DOM 1..4
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 5..25
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 26..407
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT MOTIF 119..121
FT /note="Involved in the stabilization of the negatively
FT charged intermediate by the formation of the oxyanion hole"
FT /evidence="ECO:0000250|UniProtKB:Q5NUF3"
FT ACT_SITE 193
FT /evidence="ECO:0000250|UniProtKB:Q8BLF1"
FT ACT_SITE 347
FT /evidence="ECO:0000250|UniProtKB:Q8BLF1"
FT ACT_SITE 377
FT /evidence="ECO:0000250|UniProtKB:Q8BLF1"
FT CARBOHYD 168
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 269
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 407 AA; 46082 MW; CE95EEE9A2C49970 CRC64;
MAVPWLVLLL ALPIFFLGVF VWAVFEHFLT TDIPATLQHP AKLRFLHCIF LYLVTLGNIF
EKLGICSMPK FIRFLHDSVR IKKDPELVVT DLRFGTIPVR LFQPKAASSR PRRGIIFYHG
GATVFGSLDC YHGLCNYLAR ETESVLLMIG YRKLPDHHSP ALFQDCMNAS IHFLKALETY
GVDPSRVVVC GESVGGAAVA AITQALVGRS DLPRIRAQVL IYPVVQAFCL QLPSFQQNQN
VPLLSRKFMV TSLCNYLAID LSWRDAILNG TCVPPDVWRK YEKWLSPDNI PKKFKNRGYQ
PWSPGPFNEA AYLEAKHMLD VENSPLIADD EVIAQLPEAF LVSCENDILR DDSLLYKKRL
EDQGVRVTWY HLYDGFHGSI IFFDKKALSF PCSLKIVNAV VSYIKGI
