DIVK_BRUAB
ID DIVK_BRUAB Reviewed; 123 AA.
AC Q7BBW0; Q578B0; Q9RHA3;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Polar-differentiation response regulator DivK;
GN Name=divK; OrderedLocusNames=BruAb2_0613;
OS Brucella abortus biovar 1 (strain 9-941).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX NCBI_TaxID=262698;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Devos D.P., Rousseau C., Depiereux E., Letesson J.-J.;
RT "A phosphorelay in Brucella species.";
RL Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=544 / Biovar 1;
RX PubMed=11929544; DOI=10.1046/j.1365-2958.2002.02777.x;
RA Bellefontaine A.F., Pierreux C.E., Mertens P., Vandenhaute J.,
RA Letesson J.J., De Bolle X.;
RT "Plasticity of a transcriptional regulation network among alpha-
RT proteobacteria is supported by the identification of CtrA targets in
RT Brucella abortus.";
RL Mol. Microbiol. 43:945-960(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=9-941;
RX PubMed=15805518; DOI=10.1128/jb.187.8.2715-2726.2005;
RA Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z.,
RA Li L.-L., Kapur V., Alt D.P., Olsen S.C.;
RT "Completion of the genome sequence of Brucella abortus and comparison to
RT the highly similar genomes of Brucella melitensis and Brucella suis.";
RL J. Bacteriol. 187:2715-2726(2005).
RN [4]
RP FUNCTION IN CONTROL OF CELL SHAPE, DISRUPTION PHENOTYPE, SUBCELLULAR
RP LOCATION, PHOSPHORYLATION AT ASP-53, INTERACTION WITH DIVL/PLEC/DIVJ/PDHS,
RP AND MUTAGENESIS OF ASP-53.
RC STRAIN=544 / Biovar 1;
RX PubMed=17304218; DOI=10.1038/sj.emboj.7601577;
RA Hallez R., Mignolet J., Van Mullem V., Wery M., Vandenhaute J.,
RA Letesson J.-J., Jacobs-Wagner C., De Bolle X.;
RT "The asymmetric distribution of the essential histidine kinase PdhS
RT indicates a differentiation event in Brucella abortus.";
RL EMBO J. 26:1444-1455(2007).
CC -!- FUNCTION: Essential protein that is involved in the control of cell
CC division, probably through the regulation of ctrA. Its phosphorylation
CC status is regulated by PdhS. {ECO:0000269|PubMed:17304218}.
CC -!- SUBUNIT: Interacts with DivL, PleC, DivJ and PdhS.
CC {ECO:0000269|PubMed:17304218}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17304218}.
CC Note=Localized at one pole of the cell. Colocalizes with PdhS.
CC -!- DISRUPTION PHENOTYPE: Lethal. {ECO:0000269|PubMed:17304218}.
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DR EMBL; AF051940; AAF14690.1; -; mRNA.
DR EMBL; AF411569; AAL86375.1; -; Genomic_DNA.
DR EMBL; AE017224; AAX76024.1; -; Genomic_DNA.
DR RefSeq; WP_002966022.1; NC_006933.1.
DR AlphaFoldDB; Q7BBW0; -.
DR SMR; Q7BBW0; -.
DR IntAct; Q7BBW0; 3.
DR MINT; Q7BBW0; -.
DR EnsemblBacteria; AAX76024; AAX76024; BruAb2_0613.
DR GeneID; 45125960; -.
DR GeneID; 55592281; -.
DR KEGG; bmb:BruAb2_0613; -.
DR HOGENOM; CLU_000445_69_17_5; -.
DR OMA; RDYITKP; -.
DR PRO; PR:Q7BBW0; -.
DR Proteomes; UP000000540; Chromosome II.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR Pfam; PF00072; Response_reg; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; DNA-binding; Phosphoprotein; Transcription;
KW Transcription regulation; Two-component regulatory system.
FT CHAIN 1..123
FT /note="Polar-differentiation response regulator DivK"
FT /id="PRO_0000363206"
FT DOMAIN 4..120
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT MOD_RES 53
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169,
FT ECO:0000269|PubMed:17304218"
FT MUTAGEN 53
FT /note="D->A: Abolishes phosphorylation and localization to
FT the cell pole."
FT /evidence="ECO:0000269|PubMed:17304218"
FT CONFLICT 92
FT /note="E -> R (in Ref. 1; AAF14690)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 123 AA; 13973 MW; 0D74511EB774FA24 CRC64;
MTKSVMIVED NELNMKLFRD LIEASGYETI RTRSGLEALD LAREHHPDLI LMDIQLPEVS
GLEVTKWLKD DEELRHIPVI AVTAFAMKGD EERIRQGGCE AYISKPISVP RFIETIKSYL
GDA
