ID   DIVK_BRUME              Reviewed;         123 AA.
AC   Q8YC73;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Polar-differentiation response regulator DivK;
GN   Name=divK; OrderedLocusNames=BMEII0659;
OS   Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=224914;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=16M / ATCC 23456 / NCTC 10094;
RX   PubMed=11756688; DOI=10.1073/pnas.221575398;
RA   DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T.,
RA   Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G.,
RA   Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E.,
RA   Selkov E., Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J.,
RA   Haselkorn R., Kyrpides N.C., Overbeek R.;
RT   "The genome sequence of the facultative intracellular pathogen Brucella
RT   melitensis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002).
CC   -!- FUNCTION: Essential protein that is involved in the control of cell
CC       division, probably through the regulation of ctrA. Its phosphorylation
CC       status is regulated by PdhS (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with DivL, PleC, DivJ and PdhS. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Localized at one
CC       pole of the cell. Colocalizes with PdhS (By similarity). {ECO:0000250}.
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DR   EMBL; AE008918; AAL53901.1; -; Genomic_DNA.
DR   PIR; AB3592; AB3592.
DR   RefSeq; WP_002966022.1; NZ_GG703779.1.
DR   AlphaFoldDB; Q8YC73; -.
DR   SMR; Q8YC73; -.
DR   IntAct; Q8YC73; 1.
DR   STRING; 224914.BMEII0659; -.
DR   EnsemblBacteria; AAL53901; AAL53901; BMEII0659.
DR   GeneID; 45125960; -.
DR   GeneID; 55592281; -.
DR   KEGG; bme:BMEII0659; -.
DR   PATRIC; fig|224914.52.peg.2710; -.
DR   eggNOG; COG0784; Bacteria.
DR   OMA; RDYITKP; -.
DR   Proteomes; UP000000419; Chromosome II.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   Pfam; PF00072; Response_reg; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Phosphoprotein; Transcription;
KW   Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..123
FT                   /note="Polar-differentiation response regulator DivK"
FT                   /id="PRO_0000363208"
FT   DOMAIN          4..120
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   MOD_RES         53
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   123 AA;  13973 MW;  0D74511EB774FA24 CRC64;
     MTKSVMIVED NELNMKLFRD LIEASGYETI RTRSGLEALD LAREHHPDLI LMDIQLPEVS
     GLEVTKWLKD DEELRHIPVI AVTAFAMKGD EERIRQGGCE AYISKPISVP RFIETIKSYL
     GDA