DIX1A_DANRE
ID DIX1A_DANRE Reviewed; 443 AA.
AC Q804T6;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Dixin-A;
DE AltName: Full=Coiled-coil protein DIX1-A;
DE Short=Coiled-coil-DIX1-A;
DE AltName: Full=DIX domain-containing protein 1-A;
GN Name=dixdc1a; Synonyms=ccd1, dixdc1;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, OLIGOMERIZATION,
RP AND INTERACTION WITH DISHEVELLED AND AXIN1.
RX PubMed=12526749; DOI=10.1016/s0960-9822(02)01398-2;
RA Shiomi K., Uchida H., Keino-Masu K., Masu M.;
RT "Ccd1, a novel protein with a DIX domain, is a positive regulator in the
RT Wnt signaling during zebrafish neural patterning.";
RL Curr. Biol. 13:73-77(2003).
CC -!- FUNCTION: Functions as a positive effector of the Wnt signaling pathway
CC regulating antero-posterior neural patterning.
CC {ECO:0000269|PubMed:12526749}.
CC -!- SUBUNIT: Homomers. Interacts with dishevelled and axin1.
CC {ECO:0000269|PubMed:12526749}.
CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion {ECO:0000250}.
CC Cytoplasm {ECO:0000250}.
CC -!- DEVELOPMENTAL STAGE: Expressed throughout the embryo including the
CC shield. Strongly expressed in notochord and head regions from the bud
CC to somite stages. Expressed in early born neurons in the telencephalic
CC nucleus, the nuclei of the tract of the post-optic commissure and of
CC the medial longitudinal fasciculus, and in segmental clusters of
CC neurons in the hindbrain. {ECO:0000269|PubMed:12526749}.
CC -!- DOMAIN: The DIX domain mediates self-interaction and interaction with
CC dishevelled and axin1.
CC -!- SIMILARITY: Belongs to the DIXDC1 family. {ECO:0000305}.
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DR EMBL; AF502143; AAO31595.1; -; mRNA.
DR RefSeq; NP_878304.1; NM_182884.1.
DR PDB; 5Y3C; X-ray; 1.96 A; A=356-438.
DR PDBsum; 5Y3C; -.
DR AlphaFoldDB; Q804T6; -.
DR SMR; Q804T6; -.
DR STRING; 7955.ENSDARP00000073184; -.
DR PaxDb; Q804T6; -.
DR PRIDE; Q804T6; -.
DR GeneID; 360137; -.
DR KEGG; dre:360137; -.
DR CTD; 360137; -.
DR ZFIN; ZDB-GENE-030721-2; dixdc1a.
DR eggNOG; ENOG502RD5G; Eukaryota.
DR InParanoid; Q804T6; -.
DR OrthoDB; 949210at2759; -.
DR PhylomeDB; Q804T6; -.
DR SignaLink; Q804T6; -.
DR PRO; PR:Q804T6; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR GO; GO:0042802; F:identical protein binding; IPI:ZFIN.
DR GO; GO:0043010; P:camera-type eye development; IMP:ZFIN.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IDA:ZFIN.
DR GO; GO:0030900; P:forebrain development; IMP:ZFIN.
DR Gene3D; 2.40.240.130; -; 1.
DR InterPro; IPR001158; DIX.
DR InterPro; IPR038207; DIX_dom_sf.
DR InterPro; IPR029800; Dixin.
DR InterPro; IPR015506; Dsh/Dvl-rel.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR10878; PTHR10878; 1.
DR PANTHER; PTHR10878:SF22; PTHR10878:SF22; 1.
DR Pfam; PF00778; DIX; 1.
DR SMART; SM00021; DAX; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS50841; DIX; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell junction; Coiled coil; Cytoplasm; Developmental protein;
KW Reference proteome; Wnt signaling pathway.
FT CHAIN 1..443
FT /note="Dixin-A"
FT /id="PRO_0000287226"
FT DOMAIN 357..439
FT /note="DIX"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00069"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 46..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 309..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 71..240
FT /evidence="ECO:0000255"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..342
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT STRAND 360..368
FT /evidence="ECO:0007829|PDB:5Y3C"
FT STRAND 373..379
FT /evidence="ECO:0007829|PDB:5Y3C"
FT TURN 381..383
FT /evidence="ECO:0007829|PDB:5Y3C"
FT HELIX 386..393
FT /evidence="ECO:0007829|PDB:5Y3C"
FT STRAND 400..407
FT /evidence="ECO:0007829|PDB:5Y3C"
FT TURN 408..410
FT /evidence="ECO:0007829|PDB:5Y3C"
FT STRAND 411..416
FT /evidence="ECO:0007829|PDB:5Y3C"
FT STRAND 430..436
FT /evidence="ECO:0007829|PDB:5Y3C"
SQ SEQUENCE 443 AA; 50439 MW; F828E90318BD096E CRC64;
MGAKQMKCLS SSSPSHTPKE EYIIAKSEDS GELVGNHTEQ PQSLEDVVKS SATDPYPGPE
HVVKEESSTW EEQLCAQQEQ LEKEMQETRK MVSRLQALLL HGSLPEDEQT STLSFGDTAS
SEQQLILTRS RLDQSMEESL DLKRELLRYK QEARNLQAVK DALQQRMSVQ EDSVLQLKQE
LLRSSMTREE LEGQNVELER KLSERNRLLS EYKKELGQKD RLLQQQQTKL DDALRRISES
YHRLSGCENN GYSHMMDTSS AVFQHRMGDE LQLVRDALRS LRDSFSGHDP QHHTLDTLEQ
GVASLVDRLH TSDTKKRPER KGSTRSPGRK ANHTDRESWP STSKIAHSHS SPVLSAAAST
KVLYYTDRSL TPFLVNIPKR LGDVTLQDFK AAVDRHGSFR YHFKSLDPEF GTVKEEVFQD
DAVIPGWEGK IVAWVEEDHG EGR
