DJ1C_ARATH
ID DJ1C_ARATH Reviewed; 472 AA.
AC Q8VY09; B9DHC7; O49502;
DT 06-MAR-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Protein DJ-1 homolog C;
DE Short=AtDJ1C;
DE Flags: Precursor;
GN Name=DJ1C; OrderedLocusNames=At4g34020; ORFNames=F17I5.210;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia; TISSUE=Rosette leaf;
RX PubMed=19423640; DOI=10.1093/dnares/dsp009;
RA Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M.,
RA Shinozaki K.;
RT "Analysis of multiple occurrences of alternative splicing events in
RT Arabidopsis thaliana using novel sequenced full-length cDNAs.";
RL DNA Res. 16:155-164(2009).
RN [5]
RP SUBCELLULAR LOCATION.
RX PubMed=20406884; DOI=10.1242/jcs.063222;
RA Xu X.M., Lin H., Maple J., Bjoerkblom B., Alves G., Larsen J.P.,
RA Moeller S.G.;
RT "The Arabidopsis DJ-1a protein confers stress protection through cytosolic
RT SOD activation.";
RL J. Cell Sci. 123:1644-1651(2010).
RN [6]
RP FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=21886817; DOI=10.1371/journal.pone.0023731;
RA Lin J., Nazarenus T.J., Frey J.L., Liang X., Wilson M.A., Stone J.M.;
RT "A plant DJ-1 homolog is essential for Arabidopsis thaliana chloroplast
RT development.";
RL PLoS ONE 6:E23731-E23731(2011).
CC -!- FUNCTION: Plays an essential role in chloroplast development and is
CC required for chloroplast integrity and viability.
CC {ECO:0000269|PubMed:21886817}.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast
CC {ECO:0000269|PubMed:20406884}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8VY09-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8VY09-2; Sequence=VSP_046014;
CC -!- TISSUE SPECIFICITY: Expressed in young leaves.
CC {ECO:0000269|PubMed:21886817}.
CC -!- DISRUPTION PHENOTYPE: Albino phenotype and seedling lethal when
CC homozygous. The phenotype is due to the absence of thylakoid membranes
CC and granal stacks in plastids. {ECO:0000269|PubMed:21886817}.
CC -!- MISCELLANEOUS: DJ1C lacks the catalytic cysteine residues in the
CC endopeptidase domains which is a highly conserved feature of the
CC family. However these residues are not essential for the function of
CC DJ1C in chloroplast development (PubMed:21886817).
CC {ECO:0000305|PubMed:21886817}.
CC -!- SIMILARITY: Belongs to the peptidase C56 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA17570.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAA19884.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB80119.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL021961; CAA17570.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL031032; CAA19884.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161584; CAB80119.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE86310.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE86311.1; -; Genomic_DNA.
DR EMBL; AY074295; AAL66992.1; -; mRNA.
DR EMBL; AY096711; AAM20345.1; -; mRNA.
DR EMBL; AK317479; BAH20144.1; -; mRNA.
DR PIR; T05230; T05230.
DR RefSeq; NP_001031787.1; NM_001036710.1. [Q8VY09-2]
DR RefSeq; NP_195128.2; NM_119563.5. [Q8VY09-1]
DR AlphaFoldDB; Q8VY09; -.
DR SMR; Q8VY09; -.
DR STRING; 3702.AT4G34020.1; -.
DR PaxDb; Q8VY09; -.
DR PRIDE; Q8VY09; -.
DR ProteomicsDB; 222144; -. [Q8VY09-1]
DR EnsemblPlants; AT4G34020.1; AT4G34020.1; AT4G34020. [Q8VY09-1]
DR EnsemblPlants; AT4G34020.2; AT4G34020.2; AT4G34020. [Q8VY09-2]
DR GeneID; 829548; -.
DR Gramene; AT4G34020.1; AT4G34020.1; AT4G34020. [Q8VY09-1]
DR Gramene; AT4G34020.2; AT4G34020.2; AT4G34020. [Q8VY09-2]
DR KEGG; ath:AT4G34020; -.
DR Araport; AT4G34020; -.
DR TAIR; locus:2124246; AT4G34020.
DR eggNOG; KOG2764; Eukaryota.
DR HOGENOM; CLU_000445_44_0_1; -.
DR InParanoid; Q8VY09; -.
DR OrthoDB; 645153at2759; -.
DR PhylomeDB; Q8VY09; -.
DR BRENDA; 4.2.1.130; 399.
DR PRO; PR:Q8VY09; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q8VY09; baseline and differential.
DR Genevisible; Q8VY09; AT.
DR GO; GO:0009507; C:chloroplast; IDA:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0009658; P:chloroplast organization; IMP:TAIR.
DR GO; GO:1903189; P:glyoxal metabolic process; IBA:GO_Central.
DR Gene3D; 3.40.50.880; -; 2.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR006287; DJ-1.
DR InterPro; IPR002818; DJ-1/PfpI.
DR Pfam; PF01965; DJ-1_PfpI; 2.
DR SUPFAM; SSF52317; SSF52317; 2.
DR TIGRFAMs; TIGR01383; not_thiJ; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Chloroplast; Plastid; Reference proteome; Repeat;
KW Transit peptide.
FT TRANSIT 1..60
FT /note="Chloroplast"
FT /evidence="ECO:0000255"
FT CHAIN 61..472
FT /note="Protein DJ-1 homolog C"
FT /id="PRO_0000421815"
FT DOMAIN 84..250
FT /note="PfpI endopeptidase 1"
FT DOMAIN 287..453
FT /note="PfpI endopeptidase 2"
FT VAR_SEQ 86..120
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:19423640"
FT /id="VSP_046014"
SQ SEQUENCE 472 AA; 50987 MW; DFB3462904052C52 CRC64;
MGSLGYSISM IASLSPTLME SRLISSMGCV SMTVAPSFSS VSVVSSSLGT TRRDRTLKLR
SSMSPGMVTT LDSDVGVGSS ATTKKVLVPI GYGTEEIEAV VLVDVLRRAG ADVTVASVEQ
KLEVEGSSGT RLLADVLISK CADQVYDLVA LPGGMPGAVR LRDCEILEKI MKRQAEDKRL
YGAISMAPAI TLLPWGLLTR KRTTGHPAFF GKLPTFWAVK TNIQISGELT TSRGPGTSFQ
FALSLAEQLF GETTAKSIEE FLLLRDGYQN PKNKEFNSID WSLDHTPRVL IPVANGSEAV
ELVSIADVLR RAKVDVTVSS VERSLRITAF QGTKIITDKL IGEAAESSYD LIILPGGHTG
SERLQKSKIL KKLLREQHES GRIYGATNSS STVLHKHGLL KEKRTTVYPS ESDEPMNQQM
IEGAEVVIDG NVITSLGLAT VTKFSLAIVS KLFGHARARS VSEGLVHEYP RQ
