ID   DJ1_DICDI               Reviewed;         205 AA.
AC   Q54MG7;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Protein DJ-1 homolog;
GN   ORFNames=DDB_G0285969;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Protects cells against oxidative stress and cell death.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase C56 family. {ECO:0000305}.
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DR   EMBL; AAFI02000082; EAL64519.1; -; Genomic_DNA.
DR   RefSeq; XP_638023.1; XM_632931.1.
DR   AlphaFoldDB; Q54MG7; -.
DR   SMR; Q54MG7; -.
DR   STRING; 44689.DDB0267060; -.
DR   PaxDb; Q54MG7; -.
DR   EnsemblProtists; EAL64519; EAL64519; DDB_G0285969.
DR   GeneID; 8625374; -.
DR   KEGG; ddi:DDB_G0285969; -.
DR   dictyBase; DDB_G0285969; deeJ.
DR   eggNOG; KOG2764; Eukaryota.
DR   HOGENOM; CLU_000445_44_2_1; -.
DR   InParanoid; Q54MG7; -.
DR   OMA; FETMEFS; -.
DR   PhylomeDB; Q54MG7; -.
DR   PRO; PR:Q54MG7; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0005737; C:cytoplasm; IDA:dictyBase.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; IMP:dictyBase.
DR   GO; GO:0031288; P:sorocarp morphogenesis; IMP:dictyBase.
DR   Gene3D; 3.40.50.880; -; 1.
DR   InterPro; IPR029062; Class_I_gatase-like.
DR   InterPro; IPR002818; DJ-1/PfpI.
DR   Pfam; PF01965; DJ-1_PfpI; 1.
DR   SUPFAM; SSF52317; SSF52317; 1.
PE   3: Inferred from homology;
KW   Chaperone; Reference proteome.
FT   CHAIN           1..205
FT                   /note="Protein DJ-1 homolog"
FT                   /id="PRO_0000331198"
SQ   SEQUENCE   205 AA;  22866 MW;  626B0C7B3F6CC6E1 CRC64;
     MTKKILLLLC KGFEVMEFTP FVDVMGWARE DDNNEDKADI QVVTCGLYNK MVTSTFGVKV
     QVDVLLGEVV KSLDEFDALA IPGGFENYSF YEEAYSEDVS QLIRDFDSKG KHIASVCVAA
     LALGKSGILK GRNATTYRNS LREHSVRQQQ LRDFGANVIA DQSIVIDKNV ITSYNPQTAP
     YVAFELLSRL SDENKAKKVK TLMGF