DJC12_MOUSE
ID DJC12_MOUSE Reviewed; 198 AA.
AC Q9R022;
DT 01-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=DnaJ homolog subfamily C member 12;
DE AltName: Full=J domain-containing protein 1;
GN Name=Dnajc12; Synonyms=Jdp1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10542335; DOI=10.1016/s0167-4781(99)00162-1;
RA Hahn Y., Lee J., Seong C., Yoon J., Chung J.H.;
RT "Structural analysis of phylogenetically conserved J domain protein gene.";
RL Biochim. Biophys. Acta 1447:325-333(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-160; SER-166 AND SER-182, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, and Pancreas;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Interacts with HSPA8. {ECO:0000250|UniProtKB:Q9UKB3}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9UKB3}.
CC -!- TISSUE SPECIFICITY: Ubiquitous. Highest levels of expression in kidney.
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DR EMBL; AF132906; AAD48756.2; -; mRNA.
DR EMBL; BC013501; AAH13501.1; -; mRNA.
DR CCDS; CCDS23899.1; -.
DR RefSeq; NP_038916.1; NM_013888.3.
DR AlphaFoldDB; Q9R022; -.
DR SMR; Q9R022; -.
DR STRING; 10090.ENSMUSP00000041298; -.
DR iPTMnet; Q9R022; -.
DR PhosphoSitePlus; Q9R022; -.
DR MaxQB; Q9R022; -.
DR PaxDb; Q9R022; -.
DR PRIDE; Q9R022; -.
DR ProteomicsDB; 279419; -.
DR Antibodypedia; 28382; 86 antibodies from 20 providers.
DR DNASU; 30045; -.
DR Ensembl; ENSMUST00000043317; ENSMUSP00000041298; ENSMUSG00000036764.
DR GeneID; 30045; -.
DR KEGG; mmu:30045; -.
DR UCSC; uc007fkg.2; mouse.
DR CTD; 56521; -.
DR MGI; MGI:1353428; Dnajc12.
DR VEuPathDB; HostDB:ENSMUSG00000036764; -.
DR eggNOG; KOG0691; Eukaryota.
DR GeneTree; ENSGT00940000159378; -.
DR HOGENOM; CLU_118857_2_0_1; -.
DR InParanoid; Q9R022; -.
DR OMA; RSNYDKW; -.
DR OrthoDB; 1499433at2759; -.
DR PhylomeDB; Q9R022; -.
DR TreeFam; TF105171; -.
DR BioGRID-ORCS; 30045; 5 hits in 74 CRISPR screens.
DR ChiTaRS; Dnajc12; mouse.
DR PRO; PR:Q9R022; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q9R022; protein.
DR Bgee; ENSMUSG00000036764; Expressed in adult mammalian kidney and 240 other tissues.
DR ExpressionAtlas; Q9R022; baseline and differential.
DR Genevisible; Q9R022; MM.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR CDD; cd06257; DnaJ; 1.
DR Gene3D; 1.10.287.110; -; 1.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR036869; J_dom_sf.
DR InterPro; IPR029827; JDP1-like.
DR PANTHER; PTHR44500; PTHR44500; 1.
DR Pfam; PF00226; DnaJ; 1.
DR PRINTS; PR00625; JDOMAIN.
DR SMART; SM00271; DnaJ; 1.
DR SUPFAM; SSF46565; SSF46565; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
PE 1: Evidence at protein level;
KW Acetylation; Chaperone; Cytoplasm; Phosphoprotein; Reference proteome.
FT CHAIN 1..198
FT /note="DnaJ homolog subfamily C member 12"
FT /id="PRO_0000071067"
FT DOMAIN 14..79
FT /note="J"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
FT REGION 114..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..155
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q9UKB3"
FT MOD_RES 160
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 166
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 182
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 198 AA; 22853 MW; BF7583D399495240 CRC64;
MDAILNYRPE GSEDYYALLG CDELSSVEQI LAEFKIRALE CHPDKHPENS KAVETFQKLQ
KAKEILCNAE SRARYDHWRR SQMSMPFEQW EALADSVKTS MHWAVRSKKD LMLEGSGQTF
TSSVPNKERS EQRETKKGDP DSNPEKMKQK EPKFPEEGIS PQNPDSPGLS DLNCGHLRFR
WSGDAPSELL RKFRNYEI
