DJC14_HUMAN
ID DJC14_HUMAN Reviewed; 702 AA.
AC Q6Y2X3; A5YM67; Q17RY2; Q66K17; Q96N59; Q96T63;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 2.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=DnaJ homolog subfamily C member 14;
DE AltName: Full=DnaJ protein homolog 3;
DE AltName: Full=Dopamine receptor-interacting protein of 78 kDa;
DE Short=DRIP78;
DE AltName: Full=Human DnaJ protein 3;
DE Short=hDj-3;
GN Name=DNAJC14; Synonyms=DRIP78, HDJ3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Fetal brain;
RX PubMed=12768437; DOI=10.1007/s10038-003-0012-8;
RA Chen J., Huang Y., Wu H., Ni X., Cheng H., Fan J., Gu S., Gu X., Cao G.,
RA Ying K., Mao Y., Lu Y., Xie Y.;
RT "Molecular cloning and characterization of a novel human J-domain protein
RT gene (HDJ3) from the fetal brain.";
RL J. Hum. Genet. 48:217-221(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 254-702.
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 490-702.
RX PubMed=11331877; DOI=10.1038/35074561;
RA Bermak J.C., Li M., Bullock C.M., Zhou Q.-Y.;
RT "Regulation of transport of the dopamine D1 receptor by a new membrane-
RT associated ER protein.";
RL Nat. Cell Biol. 3:492-498(2001).
CC -!- FUNCTION: Regulates the export of target proteins, such as DRD1, from
CC the endoplasmic reticulum to the cell surface. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with the FxxxFxxxF motif of DRD1 via its C-terminal
CC domain. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Highly expressed in pancreas and selectively
CC expressed in brain, lung, liver, skeletal muscle and kidney.
CC {ECO:0000269|PubMed:12768437}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB71050.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY188447; AAO73451.1; -; mRNA.
DR EMBL; EF560741; ABQ59051.1; -; mRNA.
DR EMBL; CH471054; EAW96833.1; -; Genomic_DNA.
DR EMBL; BC080655; AAH80655.1; -; mRNA.
DR EMBL; BC117146; AAI17147.1; -; mRNA.
DR EMBL; BC117148; AAI17149.1; -; mRNA.
DR EMBL; AK055945; BAB71050.1; ALT_INIT; mRNA.
DR EMBL; AF351784; AAK56241.1; -; mRNA.
DR CCDS; CCDS8894.1; -.
DR RefSeq; NP_115740.5; NM_032364.5.
DR AlphaFoldDB; Q6Y2X3; -.
DR SMR; Q6Y2X3; -.
DR BioGRID; 124515; 49.
DR CORUM; Q6Y2X3; -.
DR IntAct; Q6Y2X3; 5.
DR MINT; Q6Y2X3; -.
DR STRING; 9606.ENSP00000350223; -.
DR GlyGen; Q6Y2X3; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q6Y2X3; -.
DR PhosphoSitePlus; Q6Y2X3; -.
DR BioMuta; DNAJC14; -.
DR DMDM; 110808200; -.
DR EPD; Q6Y2X3; -.
DR jPOST; Q6Y2X3; -.
DR MassIVE; Q6Y2X3; -.
DR MaxQB; Q6Y2X3; -.
DR PaxDb; Q6Y2X3; -.
DR PeptideAtlas; Q6Y2X3; -.
DR PRIDE; Q6Y2X3; -.
DR ProteomicsDB; 67835; -.
DR Antibodypedia; 3011; 66 antibodies from 15 providers.
DR DNASU; 85406; -.
DR Ensembl; ENST00000317287.5; ENSP00000317500.5; ENSG00000135392.19.
DR Ensembl; ENST00000357606.7; ENSP00000350223.3; ENSG00000135392.19.
DR Ensembl; ENST00000546957.2; ENSP00000448876.2; ENSG00000135392.19.
DR Ensembl; ENST00000547445.2; ENSP00000450196.2; ENSG00000135392.19.
DR Ensembl; ENST00000678005.2; ENSP00000504134.1; ENSG00000135392.19.
DR GeneID; 85406; -.
DR KEGG; hsa:85406; -.
DR MANE-Select; ENST00000678005.2; ENSP00000504134.1; NM_032364.6; NP_115740.5.
DR UCSC; uc001shx.1; human.
DR CTD; 85406; -.
DR DisGeNET; 85406; -.
DR GeneCards; DNAJC14; -.
DR HGNC; HGNC:24581; DNAJC14.
DR HPA; ENSG00000135392; Low tissue specificity.
DR MIM; 606092; gene.
DR neXtProt; NX_Q6Y2X3; -.
DR OpenTargets; ENSG00000135392; -.
DR PharmGKB; PA134940402; -.
DR VEuPathDB; HostDB:ENSG00000135392; -.
DR eggNOG; KOG0720; Eukaryota.
DR GeneTree; ENSGT00940000155637; -.
DR HOGENOM; CLU_020746_0_0_1; -.
DR InParanoid; Q6Y2X3; -.
DR OMA; VQRGWLE; -.
DR OrthoDB; 1434217at2759; -.
DR PhylomeDB; Q6Y2X3; -.
DR TreeFam; TF105173; -.
DR PathwayCommons; Q6Y2X3; -.
DR SignaLink; Q6Y2X3; -.
DR SIGNOR; Q6Y2X3; -.
DR BioGRID-ORCS; 85406; 9 hits in 1076 CRISPR screens.
DR ChiTaRS; DNAJC14; human.
DR GeneWiki; DNAJC14; -.
DR GenomeRNAi; 85406; -.
DR Pharos; Q6Y2X3; Tbio.
DR PRO; PR:Q6Y2X3; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q6Y2X3; protein.
DR Bgee; ENSG00000135392; Expressed in islet of Langerhans and 145 other tissues.
DR ExpressionAtlas; Q6Y2X3; baseline and differential.
DR Genevisible; Q6Y2X3; HS.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; HDA:UniProtKB.
DR GO; GO:0050780; F:dopamine receptor binding; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd06257; DnaJ; 1.
DR Gene3D; 1.10.287.110; -; 1.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR036869; J_dom_sf.
DR InterPro; IPR032843; Jiv.
DR Pfam; PF00226; DnaJ; 1.
DR Pfam; PF14901; Jiv90; 1.
DR PRINTS; PR00625; JDOMAIN.
DR SMART; SM00271; DnaJ; 1.
DR SUPFAM; SSF46565; SSF46565; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
PE 2: Evidence at transcript level;
KW Chaperone; Endoplasmic reticulum; Membrane; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..702
FT /note="DnaJ homolog subfamily C member 14"
FT /id="PRO_0000247493"
FT TRANSMEM 250..270
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 300..320
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 326..346
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 443..507
FT /note="J"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
FT REGION 1..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 165..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 658..702
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..61
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..85
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 114..131
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..217
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 688..702
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 285
FT /note="D -> N (in Ref. 1; AAO73451)"
FT /evidence="ECO:0000305"
FT CONFLICT 460
FT /note="K -> R (in Ref. 1; AAO73451)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 702 AA; 78569 MW; DAECF48B7196C7F2 CRC64;
MAQKHPGERG LYGAHHSGGA SLRTLGPSVD PEIPSFSGLR DSAGTAPNGT RCLTEHSGPK
HTQHPNPAHW LDPSHGPPGG PGPPRDAEDP DQSETSSEEE SGVDQELSKE NETGNQKDGN
SFLSIPSACN CQGTPGIPEG PYSEGGNGSS SNFCHHCTSP ALGEDELEEE YDDEESLKFP
SDFSRVSSGK KPPSRRQRHR FPTKEDTREG GRRDPRSPGR HRLGRKRSQA DKRKGLGLWG
AEELCQLGQA GFWWLIELLV LVGEYVETCG HLIYACRQLK SSDLDLFRVW MGVWTGRLGG
WAQVMFQFLS QGFYCGVGLF TRFLKLLGAL LLLALALFLG FLQLGWRFLV GLGDRLGWRD
KATWLFSWLD SPALQRCLTL LRDSRPWQRL VRIVQWGWLE LPWVKQNINR QGNAPVASGR
YCQPEEEVAR LLTMAGVPED ELNPFHVLGV EATASDVELK KAYRQLAVMV HPDKNHHPRA
EEAFKVLRAA WDIVSNAEKR KEYEMKRMAE NELSRSVNEF LSKLQDDLKE AMNTMMCSRC
QGKHRRFEMD REPKSARYCA ECNRLHPAEE GDFWAESSML GLKITYFALM DGKVYDITEW
AGCQRVGISP DTHRVPYHIS FGSRIPGTRG RQRATPDAPP ADLQDFLSRI FQVPPGQMPN
GNFFAAPQPA PGAAAASKPN STVPKGEAKP KRRKKVRRPF QR
