DJC14_MOUSE
ID DJC14_MOUSE Reviewed; 703 AA.
AC Q921R4; Q3TX73; Q8BUU3; Q9CYB7;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 2.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=DnaJ homolog subfamily C member 14;
GN Name=Dnajc14;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, Corpora quadrigemina, and Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS PRO-203 AND VAL-642.
RC STRAIN=Czech II; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Regulates the export of target proteins, such as DRD1, from
CC the endoplasmic reticulum to the cell surface. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with the FxxxFxxxF motif of DRD1 via its C-terminal
CC domain. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
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DR EMBL; AK017830; BAB30962.1; -; mRNA.
DR EMBL; AK045445; BAC32372.1; -; mRNA.
DR EMBL; AK082579; BAC38536.1; -; mRNA.
DR EMBL; AK159388; BAE35043.1; -; mRNA.
DR EMBL; BC011146; AAH11146.1; -; mRNA.
DR CCDS; CCDS24294.1; -.
DR RefSeq; NP_083149.3; NM_028873.4.
DR RefSeq; XP_006514312.1; XM_006514249.3.
DR RefSeq; XP_006514313.1; XM_006514250.2.
DR RefSeq; XP_006514314.1; XM_006514251.1.
DR AlphaFoldDB; Q921R4; -.
DR SMR; Q921R4; -.
DR BioGRID; 216670; 1.
DR STRING; 10090.ENSMUSP00000026410; -.
DR iPTMnet; Q921R4; -.
DR PhosphoSitePlus; Q921R4; -.
DR MaxQB; Q921R4; -.
DR PaxDb; Q921R4; -.
DR PRIDE; Q921R4; -.
DR ProteomicsDB; 279420; -.
DR DNASU; 74330; -.
DR Ensembl; ENSMUST00000026410; ENSMUSP00000026410; ENSMUSG00000025354.
DR Ensembl; ENSMUST00000217745; ENSMUSP00000151530; ENSMUSG00000025354.
DR Ensembl; ENSMUST00000219508; ENSMUSP00000151343; ENSMUSG00000025354.
DR GeneID; 74330; -.
DR KEGG; mmu:74330; -.
DR UCSC; uc007hok.1; mouse.
DR CTD; 85406; -.
DR MGI; MGI:1921580; Dnajc14.
DR VEuPathDB; HostDB:ENSMUSG00000025354; -.
DR eggNOG; KOG0720; Eukaryota.
DR GeneTree; ENSGT00940000155637; -.
DR HOGENOM; CLU_020746_0_0_1; -.
DR InParanoid; Q921R4; -.
DR OMA; VQRGWLE; -.
DR OrthoDB; 1434217at2759; -.
DR PhylomeDB; Q921R4; -.
DR TreeFam; TF105173; -.
DR BioGRID-ORCS; 74330; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Dnajc14; mouse.
DR PRO; PR:Q921R4; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q921R4; protein.
DR Bgee; ENSMUSG00000025354; Expressed in lacrimal gland and 245 other tissues.
DR ExpressionAtlas; Q921R4; baseline and differential.
DR Genevisible; Q921R4; MM.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0050780; F:dopamine receptor binding; ISO:MGI.
DR GO; GO:0001664; F:G protein-coupled receptor binding; ISO:MGI.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd06257; DnaJ; 1.
DR Gene3D; 1.10.287.110; -; 1.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR036869; J_dom_sf.
DR InterPro; IPR032843; Jiv.
DR Pfam; PF00226; DnaJ; 1.
DR Pfam; PF14901; Jiv90; 1.
DR PRINTS; PR00625; JDOMAIN.
DR SMART; SM00271; DnaJ; 1.
DR SUPFAM; SSF46565; SSF46565; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
PE 2: Evidence at transcript level;
KW Chaperone; Endoplasmic reticulum; Membrane; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..703
FT /note="DnaJ homolog subfamily C member 14"
FT /id="PRO_0000247494"
FT TRANSMEM 305..325
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 327..347
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 444..508
FT /note="J"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
FT REGION 1..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 622..643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 659..703
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..85
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..137
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..218
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 670..684
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 689..703
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 203
FT /note="L -> P (in strain: Czech II)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT VARIANT 642
FT /note="A -> V (in strain: Czech II)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT CONFLICT 268
FT /note="E -> K (in Ref. 1; BAE35043)"
FT /evidence="ECO:0000305"
FT CONFLICT 558
FT /note="R -> G (in Ref. 1; BAC38536)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 703 AA; 78919 MW; B320DB4FB06345FE CRC64;
MAQKHPGERR LCGAHRSGGT SLSTSGSSVD PEILSFSGLR DSAETAPNGT RCLKEHSGPK
YTQPPNPAHW SDPSHGPPRG PGPPRGGGYP DESETGSEES GVDQELSREN ETGYQEDGSP
SFLSIPSACN CQGSPGVPEG TYSEEGDGSS SSLCHHCTSP ALGEDEELEE EYDDEEPLKF
PSDFSRVSSG KKPLSRRQKH RFLIKEDVRD SGRREPKAPG RHRLARKRSQ TDKRRGLGLW
GVEELCQLGQ AGFWWLIELL VLVGEYVETC GHLIYACRKL KGSDLDLFRV WVGVWARRLG
GWARMMFQFL SQSFFCVVGL LIRILRVVGA FLLLALALFL GCLQLGWRFS VGLGNRLGWR
DKTAWLFSWL GSPALHHCLT LLKDSRPWQQ LVRLIQWGWQ ELPWVKQRTK KQGNAPVASG
RYCQPEEEVT RLLTMAGVPE DELNPFHVLG VEATASDTEL KKAYRQLAVM VHPDKNHHPR
AEEAFKILRA AWDIVSNPER RKEYEMKRMA ENELSRSVNE FLSKLQDDLK EAMNTMMCSR
CQGKHRRFEM DREPKSARYC AECNRLHPAE EGDFWAESSM LGLKITYFAL MDGKVYDITE
WAGCQRVGIS PDTHRVPYHI SFGSRVPGTS GRQRATPESP PADLQDFLSR IFQVPPGPMS
NGNFFAAPHP GPGTTSTSRP NSSVPKGEAK PKRRKKVRRP FQR
