DJC14_RAT
ID DJC14_RAT Reviewed; 703 AA.
AC Q5XIX0; Q925G7;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=DnaJ homolog subfamily C member 14;
DE AltName: Full=Dopamine receptor-interacting protein of 78 kDa;
DE Short=DRiP78;
GN Name=Dnajc14; Synonyms=Drip78;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH DRD1, MUTAGENESIS OF
RP CYS-538, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC STRAIN=Sprague-Dawley; TISSUE=Brain;
RX PubMed=11331877; DOI=10.1038/35074561;
RA Bermak J.C., Li M., Bullock C.M., Zhou Q.-Y.;
RT "Regulation of transport of the dopamine D1 receptor by a new membrane-
RT associated ER protein.";
RL Nat. Cell Biol. 3:492-498(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Regulates the export of target proteins, such as DRD1, from
CC the endoplasmic reticulum to the cell surface.
CC {ECO:0000269|PubMed:11331877}.
CC -!- SUBUNIT: Interacts with the FxxxFxxxF motif of DRD1 via its C-terminal
CC domain. {ECO:0000269|PubMed:11331877}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:11331877}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:11331877}.
CC -!- TISSUE SPECIFICITY: Detected in heart, brain, lung, liver, skeletal
CC muscle, kidney and testis. {ECO:0000269|PubMed:11331877}.
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DR EMBL; AF351783; AAK56240.1; -; mRNA.
DR EMBL; BC083549; AAH83549.1; -; mRNA.
DR RefSeq; NP_446142.2; NM_053690.2.
DR RefSeq; XP_006240788.1; XM_006240726.1.
DR RefSeq; XP_006240789.1; XM_006240727.2.
DR RefSeq; XP_008763233.1; XM_008765011.2.
DR RefSeq; XP_017450056.1; XM_017594567.1.
DR AlphaFoldDB; Q5XIX0; -.
DR SMR; Q5XIX0; -.
DR STRING; 10116.ENSRNOP00000029946; -.
DR iPTMnet; Q5XIX0; -.
DR PhosphoSitePlus; Q5XIX0; -.
DR PaxDb; Q5XIX0; -.
DR Ensembl; ENSRNOT00000037332; ENSRNOP00000029946; ENSRNOG00000006844.
DR GeneID; 114481; -.
DR KEGG; rno:114481; -.
DR UCSC; RGD:620489; rat.
DR CTD; 85406; -.
DR RGD; 620489; Dnajc14.
DR eggNOG; KOG0720; Eukaryota.
DR GeneTree; ENSGT00940000155637; -.
DR HOGENOM; CLU_020746_0_0_1; -.
DR InParanoid; Q5XIX0; -.
DR OMA; VQRGWLE; -.
DR OrthoDB; 1434217at2759; -.
DR PhylomeDB; Q5XIX0; -.
DR TreeFam; TF105173; -.
DR PRO; PR:Q5XIX0; -.
DR Proteomes; UP000002494; Chromosome 7.
DR Bgee; ENSRNOG00000006844; Expressed in lung and 20 other tissues.
DR Genevisible; Q5XIX0; RN.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0050780; F:dopamine receptor binding; IDA:RGD.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IDA:RGD.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd06257; DnaJ; 1.
DR Gene3D; 1.10.287.110; -; 1.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR036869; J_dom_sf.
DR InterPro; IPR032843; Jiv.
DR Pfam; PF00226; DnaJ; 1.
DR Pfam; PF14901; Jiv90; 1.
DR PRINTS; PR00625; JDOMAIN.
DR SMART; SM00271; DnaJ; 1.
DR SUPFAM; SSF46565; SSF46565; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
PE 1: Evidence at protein level;
KW Chaperone; Endoplasmic reticulum; Membrane; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..703
FT /note="DnaJ homolog subfamily C member 14"
FT /id="PRO_0000247495"
FT TRANSMEM 254..274
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 305..325
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 327..347
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 444..508
FT /note="J"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
FT REGION 1..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 164..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 622..643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 659..703
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..85
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..218
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 670..684
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 689..703
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MUTAGEN 538
FT /note="C->S: Loss of interaction with DRD1."
FT /evidence="ECO:0000269|PubMed:11331877"
FT CONFLICT 65
FT /note="P -> S (in Ref. 1; AAK56240)"
FT /evidence="ECO:0000305"
FT CONFLICT 226..235
FT /note="RKRSQTDKRR -> EVRQITPE (in Ref. 1; AAK56240)"
FT /evidence="ECO:0000305"
FT CONFLICT 244
FT /note="E -> G (in Ref. 1; AAK56240)"
FT /evidence="ECO:0000305"
FT CONFLICT 416..418
FT /note="HVA -> NVP (in Ref. 1; AAK56240)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 703 AA; 79017 MW; 5D282F8A78DA2B08 CRC64;
MAQKHPGERG LCGVHHSGGS SLITSGSSVD PEILSFSGLR DSKETAPNGT RCLKEHSDPK
CTQPPNPAHW SDPSHGPPRG PGPPREGGYP DESETCSEES GVDQELSREN ETGYQEDGSP
SFLPIPSACN CQGSPGVPEG TCSEEGDGSS SSFCHHCTSP ALGEDEELEE EYDDEEPLKF
PSDFSRVSSG KKPPSRRQRH RFLTKEDVRD SGRRDPKAPG RHRLARKRSQ TDKRRGLGLW
GVEELCQLGQ AGFWWLIELL VLVGEYVETC GYLIYACRKL KGSDLDLFRI WVGVWARRLG
GWARVMFQFL SQSFFSVAGL FIRLLRVVGA FLLLALALFL GCLQLGWRFL VGLGDRLGWR
GKAAWLFSWL DSPALHHFLT LLKDSRPWQQ LVRVIQWGWL ELPWVKQRTQ RQGTAHVASG
RYCQPEEEVA RLLTMAGVPE DELNPFHVLG VEATASDIEL KKAYRQLAVM VHPDKNHHPR
AEEAFKVLRA AWDIVSNPER RKEYEMKRMA ENELSRSVNE FLSKLQDDLK EAMNTMMCSR
CQGKHRRFEM DREPKSARYC AECNRLHPAE EGDFWAESSM LGLKITYFAL MDGKVYDITE
WAGCQRVGIS PDTHRVPYHI SFGSRVPGTS GRQRATPESP PADLQDFLSR IFQVPPGPMS
NGNFFAAPHP GPGTTSTSRP NSSVPKGEAK PKRRKKVRRP FQR
