ID   DJC15_PONAB             Reviewed;         150 AA.
AC   Q5RCP4;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=DnaJ homolog subfamily C member 15;
GN   Name=DNAJC15;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of the mitochondrial respiratory chain.
CC       Prevents mitochondrial hyperpolarization state and restricts
CC       mitochondrial generation of ATP. Acts as an import component of the
CC       TIM23 translocase complex. Stimulates the ATPase activity of HSPA9 (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the TIM23 complex (By similarity). Directly
CC       interacts with PAM16/MAGMAS; this interaction counteracts DNAJC15-
CC       dependent stimulation of HSPA9 ATPase activity. Associates with complex
CC       I of the mitochondrial electron transfer chain; this interaction may
CC       interfere with the formation of supercomplexes that facilitate the
CC       transfer of electrons between complexes (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
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DR   EMBL; CR858225; CAH90463.1; -; mRNA.
DR   RefSeq; NP_001127291.1; NM_001133819.1.
DR   AlphaFoldDB; Q5RCP4; -.
DR   SMR; Q5RCP4; -.
DR   STRING; 9601.ENSPPYP00000006063; -.
DR   Ensembl; ENSPPYT00000006300; ENSPPYP00000006063; ENSPPYG00000005323.
DR   GeneID; 100174349; -.
DR   KEGG; pon:100174349; -.
DR   CTD; 29103; -.
DR   eggNOG; KOG0723; Eukaryota.
DR   GeneTree; ENSGT00940000159907; -.
DR   InParanoid; Q5RCP4; -.
DR   OrthoDB; 1600166at2759; -.
DR   Proteomes; UP000001595; Chromosome 13.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009267; P:cellular response to starvation; IEA:Ensembl.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:Ensembl.
DR   GO; GO:1902957; P:negative regulation of mitochondrial electron transport, NADH to ubiquinone; IEA:Ensembl.
DR   GO; GO:0031333; P:negative regulation of protein-containing complex assembly; IEA:Ensembl.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0065003; P:protein-containing complex assembly; IEA:Ensembl.
DR   GO; GO:0019216; P:regulation of lipid metabolic process; IEA:Ensembl.
DR   CDD; cd06257; DnaJ; 1.
DR   Gene3D; 1.10.287.110; -; 1.
DR   InterPro; IPR001623; DnaJ_domain.
DR   InterPro; IPR036869; J_dom_sf.
DR   SMART; SM00271; DnaJ; 1.
DR   SUPFAM; SSF46565; SSF46565; 1.
DR   PROSITE; PS50076; DNAJ_2; 1.
PE   2: Evidence at transcript level;
KW   Chaperone; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Phosphoprotein; Protein transport; Reference proteome; Translocation;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..150
FT                   /note="DnaJ homolog subfamily C member 15"
FT                   /id="PRO_0000247141"
FT   TOPO_DOM        1..34
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        35..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        58..150
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          96..150
FT                   /note="J"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
FT   MOD_RES         104
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y5T4"
SQ   SEQUENCE   150 AA;  16284 MW;  8DF7D3993879799D CRC64;
     MAARGVIAPV GESLRYAEYL QPSAKRPDAD VDQQGLVRSL IAVGLGVAAF AFAGRYAFRI
     WKPLEQVITE TAKKISTPSL SSYYKGGFEK KMSRREAGLI LGVSPSAGKA KIRTAHRRVM
     ILNHPDKGGS PYVAAKINEA KDLLETTTKH