DJC16_HUMAN
ID DJC16_HUMAN Reviewed; 782 AA.
AC Q9Y2G8; Q68D57; Q86X32; Q8N5P4;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 3.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=DnaJ homolog subfamily C member 16;
DE Flags: Precursor;
GN Name=DNAJC16; Synonyms=KIAA0962;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=10231032; DOI=10.1093/dnares/6.1.63;
RA Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N.,
RA Tanaka A., Kotani H., Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XIII. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 6:63-70(1999).
RN [2]
RP SEQUENCE REVISION.
RX PubMed=12168954; DOI=10.1093/dnares/9.3.99;
RA Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.;
RT "Construction of expression-ready cDNA clones for KIAA genes: manual
RT curation of 330 KIAA cDNA clones.";
RL DNA Res. 9:99-106(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Retina;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Skin, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type IV
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9Y2G8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9Y2G8-2; Sequence=VSP_018583;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA76806.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB023179; BAA76806.2; ALT_INIT; mRNA.
DR EMBL; CR749259; CAH18115.1; -; mRNA.
DR EMBL; CR749567; CAH18363.1; -; mRNA.
DR EMBL; AL512883; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL121992; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC031991; AAH31991.1; -; mRNA.
DR EMBL; BC047363; AAH47363.1; -; mRNA.
DR CCDS; CCDS30606.1; -. [Q9Y2G8-1]
DR CCDS; CCDS72710.1; -. [Q9Y2G8-2]
DR RefSeq; NP_001274740.1; NM_001287811.1. [Q9Y2G8-2]
DR RefSeq; NP_056106.1; NM_015291.3. [Q9Y2G8-1]
DR AlphaFoldDB; Q9Y2G8; -.
DR SMR; Q9Y2G8; -.
DR BioGRID; 116926; 247.
DR IntAct; Q9Y2G8; 25.
DR MINT; Q9Y2G8; -.
DR STRING; 9606.ENSP00000365007; -.
DR GlyGen; Q9Y2G8; 1 site.
DR iPTMnet; Q9Y2G8; -.
DR PhosphoSitePlus; Q9Y2G8; -.
DR BioMuta; DNAJC16; -.
DR DMDM; 108936027; -.
DR EPD; Q9Y2G8; -.
DR jPOST; Q9Y2G8; -.
DR MassIVE; Q9Y2G8; -.
DR MaxQB; Q9Y2G8; -.
DR PaxDb; Q9Y2G8; -.
DR PeptideAtlas; Q9Y2G8; -.
DR PRIDE; Q9Y2G8; -.
DR ProteomicsDB; 85773; -. [Q9Y2G8-1]
DR ProteomicsDB; 85774; -. [Q9Y2G8-2]
DR Antibodypedia; 46653; 35 antibodies from 15 providers.
DR DNASU; 23341; -.
DR Ensembl; ENST00000375847.8; ENSP00000365007.3; ENSG00000116138.13. [Q9Y2G8-1]
DR Ensembl; ENST00000616884.4; ENSP00000480224.1; ENSG00000116138.13. [Q9Y2G8-2]
DR GeneID; 23341; -.
DR KEGG; hsa:23341; -.
DR MANE-Select; ENST00000375847.8; ENSP00000365007.3; NM_015291.4; NP_056106.1.
DR UCSC; uc001aws.4; human. [Q9Y2G8-1]
DR CTD; 23341; -.
DR DisGeNET; 23341; -.
DR GeneCards; DNAJC16; -.
DR HGNC; HGNC:29157; DNAJC16.
DR HPA; ENSG00000116138; Low tissue specificity.
DR neXtProt; NX_Q9Y2G8; -.
DR OpenTargets; ENSG00000116138; -.
DR PharmGKB; PA142671964; -.
DR VEuPathDB; HostDB:ENSG00000116138; -.
DR eggNOG; KOG0715; Eukaryota.
DR GeneTree; ENSGT00940000155851; -.
DR HOGENOM; CLU_020140_0_1_1; -.
DR InParanoid; Q9Y2G8; -.
DR OMA; QREYHFR; -.
DR OrthoDB; 1253259at2759; -.
DR PhylomeDB; Q9Y2G8; -.
DR TreeFam; TF312804; -.
DR PathwayCommons; Q9Y2G8; -.
DR SignaLink; Q9Y2G8; -.
DR BioGRID-ORCS; 23341; 18 hits in 1078 CRISPR screens.
DR ChiTaRS; DNAJC16; human.
DR GenomeRNAi; 23341; -.
DR Pharos; Q9Y2G8; Tdark.
DR PRO; PR:Q9Y2G8; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q9Y2G8; protein.
DR Bgee; ENSG00000116138; Expressed in right lobe of liver and 203 other tissues.
DR ExpressionAtlas; Q9Y2G8; baseline and differential.
DR Genevisible; Q9Y2G8; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR CDD; cd06257; DnaJ; 1.
DR CDD; cd02963; TRX_DnaJ; 1.
DR Gene3D; 1.10.287.110; -; 1.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR018253; DnaJ_domain_CS.
DR InterPro; IPR043361; DNAJC16_TRX.
DR InterPro; IPR036869; J_dom_sf.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR013766; Thioredoxin_domain.
DR Pfam; PF00226; DnaJ; 1.
DR Pfam; PF00085; Thioredoxin; 1.
DR PRINTS; PR00625; JDOMAIN.
DR SMART; SM00271; DnaJ; 1.
DR SUPFAM; SSF46565; SSF46565; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
DR PROSITE; PS00636; DNAJ_1; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..782
FT /note="DnaJ homolog subfamily C member 16"
FT /id="PRO_0000236683"
FT TOPO_DOM 26..535
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 536..556
FT /note="Helical; Anchor for type IV membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 557..782
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT DOMAIN 29..93
FT /note="J"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
FT DOMAIN 119..247
FT /note="Thioredoxin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00691"
FT REGION 562..593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 565..585
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 631
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..312
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_018583"
SQ SEQUENCE 782 AA; 90591 MW; 42D564BBC6EED981 CRC64;
MEVRKLSISW QFLIVLVLIL QILSALDFDP YRVLGVSRTA SQADIKKAYK KLAREWHPDK
NKDPGAEDKF IQISKAYEIL SNEEKRSNYD QYGDAGENQG YQKQQQQREY RFRHFHENFY
FDESFFHFPF NSERRDSIDE KYLLHFSHYV NEVVPDSFKK PYLIKITSDW CFSCIHIEPV
WKEVIQELEE LGVGIGVVHA GYERRLAHHL GAHSTPSILG IINGKISFFH NAVVRENLRQ
FVESLLPGNL VEKVTNKNYV RFLSGWQQEN KPHVLLFDQT PIVPLLYKLT AFAYKDYLSF
GYVYVGLRGT EEMTRRYNIN IYAPTLLVFK EHINRPADVI QARGMKKQII DDFITRNKYL
LAARLTSQKL FHELCPVKRS HRQRKYCVVL LTAETTKLSK PFEAFLSFAL ANTQDTVRFV
HVYSNRQQEF ADTLLPDSEA FQGKSAVSIL ERRNTAGRVV YKTLEDPWIG SESDKFILLG
YLDQLRKDPA LLSSEAVLPD LTDELAPVFL LRWFYSASDY ISDCWDSIFH NNWREMMPLL
SLIFSALFIL FGTVIVQAFS DSNDERESSP PEKEEAQEKT GKTEPSFTKE NSSKIPKKGF
VEVTELTDVT YTSNLVRLRP GHMNVVLILS NSTKTSLLQK FALEVYTFTG SSCLHFSFLS
LDKHREWLEY LLEFAQDAAP IPNQYDKHFM ERDYTGYVLA LNGHKKYFCL FKPQKTVEEE
EAIGSCSDVD SSLYLGESRG KPSCGLGSRP IKGKLSKLSL WMERLLEGSL QRFYIPSWPE
LD
