DJC16_MOUSE
ID DJC16_MOUSE Reviewed; 772 AA.
AC Q80TN4; Q811G1; Q8BHI2;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 2.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=DnaJ homolog subfamily C member 16;
DE Flags: Precursor;
GN Name=Dnajc16; Synonyms=Kiaa0962;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA Nakajima D., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: II.
RT The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:35-48(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Embryo, and Skin;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 312-772, AND VARIANT ALA-478.
RC STRAIN=Czech II; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5]
RP STRUCTURE BY NMR OF 19-93.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of the J domain of the pseudo DnaJ protein, mouse
RT hypothetical mKIAA0962.";
RL Submitted (NOV-2005) to the PDB data bank.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type IV
CC membrane protein {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH46424.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC65689.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK122407; BAC65689.1; ALT_INIT; mRNA.
DR EMBL; AK028692; BAC26068.1; -; mRNA.
DR EMBL; AK051048; BAC34510.1; -; mRNA.
DR EMBL; AK154946; BAE32943.1; -; mRNA.
DR EMBL; AK164023; BAE37591.1; -; mRNA.
DR EMBL; BC046424; AAH46424.1; ALT_INIT; mRNA.
DR CCDS; CCDS18882.1; -.
DR RefSeq; NP_758841.1; NM_172338.2.
DR PDB; 2CUG; NMR; -; A=19-93.
DR PDBsum; 2CUG; -.
DR AlphaFoldDB; Q80TN4; -.
DR SMR; Q80TN4; -.
DR BioGRID; 229490; 3.
DR STRING; 10090.ENSMUSP00000048714; -.
DR GlyGen; Q80TN4; 1 site.
DR iPTMnet; Q80TN4; -.
DR PhosphoSitePlus; Q80TN4; -.
DR SwissPalm; Q80TN4; -.
DR EPD; Q80TN4; -.
DR MaxQB; Q80TN4; -.
DR PaxDb; Q80TN4; -.
DR PeptideAtlas; Q80TN4; -.
DR PRIDE; Q80TN4; -.
DR ProteomicsDB; 279540; -.
DR Antibodypedia; 46653; 35 antibodies from 15 providers.
DR DNASU; 214063; -.
DR Ensembl; ENSMUST00000038014; ENSMUSP00000048714; ENSMUSG00000040697.
DR GeneID; 214063; -.
DR KEGG; mmu:214063; -.
DR UCSC; uc008vpf.1; mouse.
DR CTD; 23341; -.
DR MGI; MGI:2442146; Dnajc16.
DR VEuPathDB; HostDB:ENSMUSG00000040697; -.
DR eggNOG; KOG0715; Eukaryota.
DR GeneTree; ENSGT00940000155851; -.
DR HOGENOM; CLU_020140_0_1_1; -.
DR InParanoid; Q80TN4; -.
DR OMA; QREYHFR; -.
DR OrthoDB; 1253259at2759; -.
DR PhylomeDB; Q80TN4; -.
DR TreeFam; TF312804; -.
DR BioGRID-ORCS; 214063; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Dnajc16; mouse.
DR EvolutionaryTrace; Q80TN4; -.
DR PRO; PR:Q80TN4; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q80TN4; protein.
DR Bgee; ENSMUSG00000040697; Expressed in otolith organ and 230 other tissues.
DR ExpressionAtlas; Q80TN4; baseline and differential.
DR Genevisible; Q80TN4; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR CDD; cd06257; DnaJ; 1.
DR CDD; cd02963; TRX_DnaJ; 1.
DR Gene3D; 1.10.287.110; -; 1.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR018253; DnaJ_domain_CS.
DR InterPro; IPR043361; DNAJC16_TRX.
DR InterPro; IPR036869; J_dom_sf.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR013766; Thioredoxin_domain.
DR Pfam; PF00226; DnaJ; 1.
DR Pfam; PF00085; Thioredoxin; 1.
DR PRINTS; PR00625; JDOMAIN.
DR SMART; SM00271; DnaJ; 1.
DR SUPFAM; SSF46565; SSF46565; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
DR PROSITE; PS00636; DNAJ_1; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Glycoprotein; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..772
FT /note="DnaJ homolog subfamily C member 16"
FT /id="PRO_0000236684"
FT TOPO_DOM 26..533
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 534..554
FT /note="Helical; Anchor for type IV membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 555..772
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT DOMAIN 29..93
FT /note="J"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
FT DOMAIN 119..245
FT /note="Thioredoxin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00691"
FT REGION 560..591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 560..583
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 629
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 478
FT /note="G -> A (in strain: Czech II)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT STRAND 25..28
FT /evidence="ECO:0007829|PDB:2CUG"
FT HELIX 30..34
FT /evidence="ECO:0007829|PDB:2CUG"
FT HELIX 42..55
FT /evidence="ECO:0007829|PDB:2CUG"
FT TURN 58..60
FT /evidence="ECO:0007829|PDB:2CUG"
FT HELIX 66..81
FT /evidence="ECO:0007829|PDB:2CUG"
FT HELIX 83..92
FT /evidence="ECO:0007829|PDB:2CUG"
SQ SEQUENCE 772 AA; 89136 MW; 1B55F9494D6E0465 CRC64;
MELKRLGVSW RFLMVLVLIL QSLSALDFDP YRVLGVSRTA SQADIKKAYK KLAREWHPDK
NKDPGAEDRF IQISKAYEIL SNEEKRTNYD HYGDAGENQG YQKQQREHRF RHFHENFYFD
ESFFHFPFNA ERRDSGDEKY LLHFSHYVNE VLPESFKRPY LIKITSDWCF SCIHIEPVWK
EVVQELEGLG VGIGVVHAGY ERRLAHHLGA HSTPSILGVI SGKITFFHNA VVHENLRQFV
ESLLPGNLVE KVTNKNYVRF LSGWQQENKP HALLFGQTPA VPLMYKLTAF AYKDYVSFGY
VYVGLRGVEE MTRQYNVNLY TPTMLIFKEH INKPADVIQA RGLKKQVIED FIAQNKYLLA
SRLTSQRLFH ELCPVKRSHR QRKYCVVLLT AETNKVSKPF EAFLSFALAN TQDTVRFVHV
YSNRQQEFAS TLLPDMEAFQ GKSGVSILER RNTAGRVVFK TLEDPWTGSE SDKFVLLGYL
DQLRKDPAFL SSEAVLPDLT DELAPVFFLR WLYSVSDYLS DFWESLLHSN WREMMPLLSL
IFSALFILFG TVMVQAFSDS NEERESHPAD KEEVPEKAGK TEPSFTKESS SKIPKKGFVE
VTELTDVTYT SNLVRLRPGH MNVVLILSNS TKTSLLQKFA LEVYTFTGSS SLHFSFLTLD
KHREWLEYLL EFAQDAAPIP NQYDKHFMER DYTGYVLALN GHKKYFCLFK PLKTVDEETV
ASCDPDSSRG KPSCGLGPKP LKGKLSKLSL WMERLLEGSL QRFYIPSWPE LD
