ID   DJC16_RAT               Reviewed;         771 AA.
AC   Q5FVM7;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=DnaJ homolog subfamily C member 16;
DE   Flags: Precursor;
GN   Name=Dnajc16;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type IV
CC       membrane protein {ECO:0000305}.
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DR   EMBL; BC089875; AAH89875.1; -; mRNA.
DR   RefSeq; NP_001014216.1; NM_001014194.1.
DR   AlphaFoldDB; Q5FVM7; -.
DR   SMR; Q5FVM7; -.
DR   STRING; 10116.ENSRNOP00000017247; -.
DR   GlyGen; Q5FVM7; 1 site.
DR   PaxDb; Q5FVM7; -.
DR   PRIDE; Q5FVM7; -.
DR   Ensembl; ENSRNOT00000017247; ENSRNOP00000017247; ENSRNOG00000012503.
DR   GeneID; 362652; -.
DR   KEGG; rno:362652; -.
DR   UCSC; RGD:1359395; rat.
DR   CTD; 23341; -.
DR   RGD; 1359395; Dnajc16.
DR   eggNOG; KOG0715; Eukaryota.
DR   GeneTree; ENSGT00940000155851; -.
DR   HOGENOM; CLU_020140_0_1_1; -.
DR   InParanoid; Q5FVM7; -.
DR   OMA; HAKHPEC; -.
DR   OrthoDB; 1253259at2759; -.
DR   PhylomeDB; Q5FVM7; -.
DR   TreeFam; TF312804; -.
DR   PRO; PR:Q5FVM7; -.
DR   Proteomes; UP000002494; Chromosome 5.
DR   Bgee; ENSRNOG00000012503; Expressed in skeletal muscle tissue and 18 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   CDD; cd06257; DnaJ; 1.
DR   CDD; cd02963; TRX_DnaJ; 1.
DR   Gene3D; 1.10.287.110; -; 1.
DR   InterPro; IPR001623; DnaJ_domain.
DR   InterPro; IPR018253; DnaJ_domain_CS.
DR   InterPro; IPR043361; DNAJC16_TRX.
DR   InterPro; IPR036869; J_dom_sf.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   Pfam; PF00226; DnaJ; 1.
DR   Pfam; PF00085; Thioredoxin; 1.
DR   PRINTS; PR00625; JDOMAIN.
DR   SMART; SM00271; DnaJ; 1.
DR   SUPFAM; SSF46565; SSF46565; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   PROSITE; PS00636; DNAJ_1; 1.
DR   PROSITE; PS50076; DNAJ_2; 1.
DR   PROSITE; PS51352; THIOREDOXIN_2; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..771
FT                   /note="DnaJ homolog subfamily C member 16"
FT                   /id="PRO_0000236686"
FT   TOPO_DOM        26..532
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        533..553
FT                   /note="Helical; Anchor for type IV membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        554..771
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          29..93
FT                   /note="J"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
FT   DOMAIN          116..244
FT                   /note="Thioredoxin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00691"
FT   REGION          559..590
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        559..582
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        628
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   771 AA;  88870 MW;  F9B65C08A01D4C63 CRC64;
     MELKRLSISW QFLIVLVLIL QSLSALDFDP YRVLGVSRTA SQADIKKAYK KLAREWHPDK
     NKDPGAEDKF IQISKAYEIL SNEEKRTNYD HYGDAGENQG YQQQREYRFR HFHENFYFDE
     SFFHFPFNSE RRDSIDEKYL LHFSHYVNEV VPDSFKKPYL IKITSDWCFS CIHIEPIWKE
     VVQELEGLGV GIGVVHAGYE RRLAHHLGAH STPSILGIIN GKISFFHNAV VHENLRQFVE
     SLLPGNLVEK VTNKNYVRFL SGWQQENKPH ALLFGQTPAA PLLYKLTAFA YKDYVSFGYV
     YVGLRGVEEM TRQYNVNIYA PTMLIFKEHI NKPADAIQAR GLKKQVIEDF ITQNKYLLAS
     RLTSQKLFHE LCPVKRSHRQ RKYCVVLLTA EANKLSKPFD AFLSFALANT QDTVRFVHVY
     SSRQQEFAST LLPDIEAFQG KSGVSILERR NTAGRVVFKT LEDPWTGSES DKFVLLGYLD
     QLRKDPAFLS SEAVLPDLTD ELAPVFLLRW LYSVSDYLSD FWESLLHSNW REMMPLLSLI
     FSALFILFGT VIVQAFSDSN EERESHPPDK EEVPEKAGKT EPSFTKESSS KIPKKGFVEV
     TELTDVTYTS NLVRLRPGHM NVVLILSNST KTSLLQKFAL EVYTFTGSSS LHFSFLTLDK
     HREWLEYLLE FAQDAAPIPN QYDKHFMERD YTGYVLALNG HKKYFCLFKP LKTVDEETVG
     SCDLDSSRGK PPCGLGPKPL KGKLSKLSLW MERLLEGSLQ RFYIPSWPEL D