DJC17_MOUSE
ID DJC17_MOUSE Reviewed; 303 AA.
AC Q91WT4; A3KGH2; Q8C5R1;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 2.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=DnaJ homolog subfamily C member 17;
GN Name=Dnajc17;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-303.
RC STRAIN=C57BL/6J; TISSUE=Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5]
RP FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=20160132; DOI=10.1210/en.2009-1240;
RA Amendola E., Sanges R., Galvan A., Dathan N., Manenti G., Ferrandino G.,
RA Alvino F.M., Di Palma T., Scarfo M., Zannini M., Dragani T.A.,
RA De Felice M., Di Lauro R.;
RT "A locus on mouse chromosome 2 is involved in susceptibility to congenital
RT hypothyroidism and contains an essential gene expressed in thyroid.";
RL Endocrinology 151:1948-1958(2010).
CC -!- FUNCTION: May negatively affect PAX8-induced thyroglobulin/TG
CC transcription. {ECO:0000269|PubMed:20160132}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:D3ZSC8}. Nucleus
CC {ECO:0000250|UniProtKB:D3ZSC8}. Note=Predominantly nuclear.
CC {ECO:0000250|UniProtKB:D3ZSC8}.
CC -!- TISSUE SPECIFICITY: Expressed in the thyroid gland.
CC {ECO:0000269|PubMed:20160132}.
CC -!- DISRUPTION PHENOTYPE: Embryonic lethal after the morula stage.
CC {ECO:0000269|PubMed:20160132}.
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DR EMBL; AL772264; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC013487; AAH13487.1; -; mRNA.
DR EMBL; AK077385; BAC36778.1; -; mRNA.
DR CCDS; CCDS16593.1; -.
DR RefSeq; NP_631878.2; NM_139139.2.
DR AlphaFoldDB; Q91WT4; -.
DR SMR; Q91WT4; -.
DR BioGRID; 213422; 71.
DR STRING; 10090.ENSMUSP00000041841; -.
DR iPTMnet; Q91WT4; -.
DR PhosphoSitePlus; Q91WT4; -.
DR EPD; Q91WT4; -.
DR jPOST; Q91WT4; -.
DR MaxQB; Q91WT4; -.
DR PaxDb; Q91WT4; -.
DR PeptideAtlas; Q91WT4; -.
DR PRIDE; Q91WT4; -.
DR ProteomicsDB; 277460; -.
DR Antibodypedia; 49787; 179 antibodies from 24 providers.
DR DNASU; 69408; -.
DR Ensembl; ENSMUST00000038439; ENSMUSP00000041841; ENSMUSG00000034278.
DR GeneID; 69408; -.
DR KEGG; mmu:69408; -.
DR UCSC; uc008ltg.2; mouse.
DR CTD; 55192; -.
DR MGI; MGI:1916658; Dnajc17.
DR VEuPathDB; HostDB:ENSMUSG00000034278; -.
DR eggNOG; KOG0691; Eukaryota.
DR GeneTree; ENSGT00940000155132; -.
DR HOGENOM; CLU_045732_1_0_1; -.
DR InParanoid; Q91WT4; -.
DR OMA; KPLHFEW; -.
DR OrthoDB; 1405648at2759; -.
DR PhylomeDB; Q91WT4; -.
DR TreeFam; TF321770; -.
DR BioGRID-ORCS; 69408; 22 hits in 75 CRISPR screens.
DR ChiTaRS; Dnajc17; mouse.
DR PRO; PR:Q91WT4; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q91WT4; protein.
DR Bgee; ENSMUSG00000034278; Expressed in lens of camera-type eye and 63 other tissues.
DR Genevisible; Q91WT4; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0005681; C:spliceosomal complex; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IGI:MGI.
DR GO; GO:0000390; P:spliceosomal complex disassembly; IBA:GO_Central.
DR GO; GO:1901998; P:toxin transport; IMP:MGI.
DR CDD; cd06257; DnaJ; 1.
DR CDD; cd12429; RRM_DNAJC17; 1.
DR Gene3D; 1.10.287.110; -; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR034254; DNAJC17_RRM.
DR InterPro; IPR036869; J_dom_sf.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00226; DnaJ; 1.
DR Pfam; PF00076; RRM_1; 1.
DR PRINTS; PR00625; JDOMAIN.
DR SMART; SM00271; DnaJ; 1.
DR SUPFAM; SSF46565; SSF46565; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
PE 1: Evidence at protein level;
KW Chaperone; Cytoplasm; Methylation; Nucleus; Phosphoprotein;
KW Reference proteome; RNA-binding; Transcription; Transcription regulation.
FT CHAIN 1..303
FT /note="DnaJ homolog subfamily C member 17"
FT /id="PRO_0000247119"
FT DOMAIN 11..76
FT /note="J"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
FT DOMAIN 178..249
FT /note="RRM"
FT REGION 104..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 150..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 112
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NVM6"
FT MOD_RES 264
FT /note="N6-methyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q9NVM6"
FT CONFLICT 152
FT /note="Q -> R (in Ref. 2; AAH13487)"
FT /evidence="ECO:0000305"
FT CONFLICT 161
FT /note="R -> E (in Ref. 2; AAH13487)"
FT /evidence="ECO:0000305"
FT CONFLICT 184
FT /note="E -> D (in Ref. 2; AAH13487)"
FT /evidence="ECO:0000305"
FT CONFLICT 258
FT /note="G -> S (in Ref. 2; AAH13487)"
FT /evidence="ECO:0000305"
FT CONFLICT 273
FT /note="F -> Y (in Ref. 2; AAH13487)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 303 AA; 34465 MW; BA9DBFAB149888B4 CRC64;
MAVTKELLQM DLYALLGIEE KAADKEVKKA YRQKALSCHP DKNPDNPRAA ELFHQLSQAL
EVLTDAAARA AYDKVRKAKK QAAERTQRLD ENRKKVKLDL EARERQAQAH GSEEEEESRS
ATTLEQEIAR LREEGSRQLE EQQRLIQEQI RQDREQRLRG RTENTEGKGT PKLKLKWKCK
KEDESQGGYS RDVLLRLLQK YGEVLNLVLS RKKAGNAIVE FATVRAAELA VRNEVGLADN
PLKVSWLEGQ PQSTVDPGPP GLSKGSVLSE RDFESLVMMR MRQAAERQQL IAQMQQEDEG
RPT
