ID   DJC17_RAT               Reviewed;         303 AA.
AC   D3ZSC8;
DT   08-JUN-2016, integrated into UniProtKB/Swiss-Prot.
DT   20-APR-2010, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=DnaJ homolog subfamily C member 17;
GN   Name=Dnajc17;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RX   PubMed=15057822; DOI=10.1038/nature02426;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2]
RP   SUBCELLULAR LOCATION.
RX   PubMed=20160132; DOI=10.1210/en.2009-1240;
RA   Amendola E., Sanges R., Galvan A., Dathan N., Manenti G., Ferrandino G.,
RA   Alvino F.M., Di Palma T., Scarfo M., Zannini M., Dragani T.A.,
RA   De Felice M., Di Lauro R.;
RT   "A locus on mouse chromosome 2 is involved in susceptibility to congenital
RT   hypothyroidism and contains an essential gene expressed in thyroid.";
RL   Endocrinology 151:1948-1958(2010).
CC   -!- FUNCTION: May negatively affect PAX8-induced thyroglobulin/TG
CC       transcription. {ECO:0000250|UniProtKB:Q91WT4}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20160132}. Nucleus
CC       {ECO:0000269|PubMed:20160132}. Note=Predominantly nuclear.
CC       {ECO:0000269|PubMed:20160132}.
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DR   EMBL; AC111293; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001178669.1; NM_001191740.1.
DR   AlphaFoldDB; D3ZSC8; -.
DR   SMR; D3ZSC8; -.
DR   STRING; 10116.ENSRNOP00000016692; -.
DR   iPTMnet; D3ZSC8; -.
DR   PhosphoSitePlus; D3ZSC8; -.
DR   PaxDb; D3ZSC8; -.
DR   PeptideAtlas; D3ZSC8; -.
DR   PRIDE; D3ZSC8; -.
DR   Ensembl; ENSRNOT00000016692; ENSRNOP00000016692; ENSRNOG00000012368.
DR   GeneID; 311329; -.
DR   KEGG; rno:311329; -.
DR   UCSC; RGD:1308015; rat.
DR   CTD; 55192; -.
DR   RGD; 1308015; Dnajc17.
DR   eggNOG; KOG0691; Eukaryota.
DR   GeneTree; ENSGT00940000155132; -.
DR   HOGENOM; CLU_045732_1_0_1; -.
DR   InParanoid; D3ZSC8; -.
DR   OMA; KPLHFEW; -.
DR   OrthoDB; 1405648at2759; -.
DR   PhylomeDB; D3ZSC8; -.
DR   TreeFam; TF321770; -.
DR   PRO; PR:D3ZSC8; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   Bgee; ENSRNOG00000012368; Expressed in spleen and 19 other tissues.
DR   Genevisible; D3ZSC8; RN.
DR   GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:0005681; C:spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
DR   GO; GO:0000390; P:spliceosomal complex disassembly; IBA:GO_Central.
DR   GO; GO:1901998; P:toxin transport; ISO:RGD.
DR   CDD; cd06257; DnaJ; 1.
DR   CDD; cd12429; RRM_DNAJC17; 1.
DR   Gene3D; 1.10.287.110; -; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR001623; DnaJ_domain.
DR   InterPro; IPR034254; DNAJC17_RRM.
DR   InterPro; IPR036869; J_dom_sf.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00226; DnaJ; 1.
DR   Pfam; PF00076; RRM_1; 1.
DR   PRINTS; PR00625; JDOMAIN.
DR   SMART; SM00271; DnaJ; 1.
DR   SUPFAM; SSF46565; SSF46565; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50076; DNAJ_2; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Methylation; Nucleus; Reference proteome;
KW   RNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..303
FT                   /note="DnaJ homolog subfamily C member 17"
FT                   /id="PRO_0000436331"
FT   DOMAIN          11..76
FT                   /note="J"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
FT   DOMAIN          178..249
FT                   /note="RRM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          78..124
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          150..170
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         264
FT                   /note="N6-methyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NVM6"
SQ   SEQUENCE   303 AA;  34544 MW;  84D9ECA6DC1C632A CRC64;
     MAVTKELLQM DLYALLGIEE KAADKEVKKA YRQKALSCHP DKNPDNPRAA ELFHQLSQAL
     EVLTDAAARA AYDKVRKARK QAAERTQRLD EKRKKVKLDL EARERQAQAQ GTEEEEESRS
     TTTLEQEIAR LREEGSRQLE EQQRLIQEQI RQDREQRLRG RTENTEGKGT PKLKLKWKCK
     KEDESQGGYS RDILLRLLQK YGEVLNLVLS KKKAGNAIVE FATVRAAELA VRNEVGLADN
     PLKVSWLEGQ PQGTVDPSPP GLSKGSVLSE RDYESLVMMR MRQAAERQQL IAQMQQEDEG
     RPT