ID   DJC18_BOVIN             Reviewed;         358 AA.
AC   Q5EA26;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=DnaJ homolog subfamily C member 18;
GN   Name=DNAJC18;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Ascending colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; BT020743; AAX08760.1; -; mRNA.
DR   EMBL; BC108139; AAI08140.1; -; mRNA.
DR   RefSeq; NP_001015649.1; NM_001015649.2.
DR   AlphaFoldDB; Q5EA26; -.
DR   SMR; Q5EA26; -.
DR   STRING; 9913.ENSBTAP00000002952; -.
DR   PaxDb; Q5EA26; -.
DR   PRIDE; Q5EA26; -.
DR   Ensembl; ENSBTAT00000002952; ENSBTAP00000002952; ENSBTAG00000002286.
DR   GeneID; 533660; -.
DR   KEGG; bta:533660; -.
DR   CTD; 202052; -.
DR   VEuPathDB; HostDB:ENSBTAG00000002286; -.
DR   VGNC; VGNC:52230; DNAJC18.
DR   eggNOG; KOG0714; Eukaryota.
DR   GeneTree; ENSGT00940000160925; -.
DR   HOGENOM; CLU_043579_3_0_1; -.
DR   InParanoid; Q5EA26; -.
DR   OMA; TGQARHY; -.
DR   OrthoDB; 1173544at2759; -.
DR   TreeFam; TF105145; -.
DR   Proteomes; UP000009136; Chromosome 7.
DR   Bgee; ENSBTAG00000002286; Expressed in occipital lobe and 105 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030544; F:Hsp70 protein binding; IBA:GO_Central.
DR   GO; GO:0071218; P:cellular response to misfolded protein; IBA:GO_Central.
DR   GO; GO:0051085; P:chaperone cofactor-dependent protein refolding; IBA:GO_Central.
DR   GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR   CDD; cd06257; DnaJ; 1.
DR   Gene3D; 1.10.287.110; -; 1.
DR   InterPro; IPR001623; DnaJ_domain.
DR   InterPro; IPR018253; DnaJ_domain_CS.
DR   InterPro; IPR015399; DUF1977_DnaJ-like.
DR   InterPro; IPR036869; J_dom_sf.
DR   Pfam; PF00226; DnaJ; 1.
DR   Pfam; PF09320; DUF1977; 1.
DR   PRINTS; PR00625; JDOMAIN.
DR   SMART; SM00271; DnaJ; 1.
DR   SUPFAM; SSF46565; SSF46565; 1.
DR   PROSITE; PS00636; DNAJ_1; 1.
DR   PROSITE; PS50076; DNAJ_2; 1.
PE   2: Evidence at transcript level;
KW   Chaperone; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..358
FT                   /note="DnaJ homolog subfamily C member 18"
FT                   /id="PRO_0000244084"
FT   TRANSMEM        228..248
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          82..146
FT                   /note="J"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
SQ   SEQUENCE   358 AA;  41603 MW;  1BBA2C22A98898FF CRC64;
     MAATLGSGER WTEAYIDAVR RNKYPEDRPP ESHDPCGCCN CMKGQKEKKS ENEWSQTRQG
     EGNSTYTEEQ LLGVQRIKKC RNYYEILGVS RDASDEELKK AYRKLALKFH PDKNCAPGAT
     DAFKAIGNAF AVLSNPDKRL RYDEYGDEQV TFTAPRARPY NYYRDFETDI TPEELFNVFF
     GGHFPTGNIH MFSNVTDDTH YYRRRHRHER MQTRKEEEED KPQTTYSAFI QLLPVLVIVI
     ISVITQLLAA NPPYSLFYKS TLGHTISRET QNLQVPYFVD KNFDKAYRGA SLRDLEKTIE
     KDYIDYIQTS CWKEKQQKSE LTNLAGLYRD ERLKQKAESL KLENCEKLSK LIGLRRGG