DJC18_HUMAN
ID DJC18_HUMAN Reviewed; 358 AA.
AC Q9H819;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=DnaJ homolog subfamily C member 18;
GN Name=DNAJC18;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AK024054; BAB14804.1; -; mRNA.
DR EMBL; BC030162; AAH30162.1; -; mRNA.
DR CCDS; CCDS4214.1; -.
DR RefSeq; NP_689899.1; NM_152686.3.
DR AlphaFoldDB; Q9H819; -.
DR SMR; Q9H819; -.
DR BioGRID; 128416; 68.
DR IntAct; Q9H819; 18.
DR MINT; Q9H819; -.
DR STRING; 9606.ENSP00000302843; -.
DR iPTMnet; Q9H819; -.
DR PhosphoSitePlus; Q9H819; -.
DR BioMuta; DNAJC18; -.
DR DMDM; 74733748; -.
DR EPD; Q9H819; -.
DR jPOST; Q9H819; -.
DR MassIVE; Q9H819; -.
DR PaxDb; Q9H819; -.
DR PeptideAtlas; Q9H819; -.
DR PRIDE; Q9H819; -.
DR ProteomicsDB; 81170; -.
DR Antibodypedia; 26786; 29 antibodies from 12 providers.
DR DNASU; 202052; -.
DR Ensembl; ENST00000302060.10; ENSP00000302843.5; ENSG00000170464.10.
DR Ensembl; ENST00000672371.1; ENSP00000500032.1; ENSG00000288275.1.
DR GeneID; 202052; -.
DR KEGG; hsa:202052; -.
DR MANE-Select; ENST00000302060.10; ENSP00000302843.5; NM_152686.4; NP_689899.1.
DR UCSC; uc003len.4; human.
DR CTD; 202052; -.
DR DisGeNET; 202052; -.
DR GeneCards; DNAJC18; -.
DR HGNC; HGNC:28429; DNAJC18.
DR HPA; ENSG00000170464; Tissue enriched (testis).
DR neXtProt; NX_Q9H819; -.
DR OpenTargets; ENSG00000170464; -.
DR PharmGKB; PA142671966; -.
DR VEuPathDB; HostDB:ENSG00000170464; -.
DR eggNOG; KOG0714; Eukaryota.
DR GeneTree; ENSGT00940000160925; -.
DR HOGENOM; CLU_043579_3_0_1; -.
DR InParanoid; Q9H819; -.
DR OMA; TGQARHY; -.
DR OrthoDB; 1173544at2759; -.
DR PhylomeDB; Q9H819; -.
DR TreeFam; TF105145; -.
DR PathwayCommons; Q9H819; -.
DR SignaLink; Q9H819; -.
DR BioGRID-ORCS; 202052; 8 hits in 1069 CRISPR screens.
DR ChiTaRS; DNAJC18; human.
DR GenomeRNAi; 202052; -.
DR Pharos; Q9H819; Tdark.
DR PRO; PR:Q9H819; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q9H819; protein.
DR Bgee; ENSG00000170464; Expressed in left testis and 103 other tissues.
DR ExpressionAtlas; Q9H819; baseline and differential.
DR Genevisible; Q9H819; HS.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030544; F:Hsp70 protein binding; IBA:GO_Central.
DR GO; GO:0071218; P:cellular response to misfolded protein; IBA:GO_Central.
DR GO; GO:0051085; P:chaperone cofactor-dependent protein refolding; IBA:GO_Central.
DR GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR CDD; cd06257; DnaJ; 1.
DR Gene3D; 1.10.287.110; -; 1.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR018253; DnaJ_domain_CS.
DR InterPro; IPR015399; DUF1977_DnaJ-like.
DR InterPro; IPR036869; J_dom_sf.
DR Pfam; PF00226; DnaJ; 1.
DR Pfam; PF09320; DUF1977; 1.
DR PRINTS; PR00625; JDOMAIN.
DR SMART; SM00271; DnaJ; 1.
DR SUPFAM; SSF46565; SSF46565; 1.
DR PROSITE; PS00636; DNAJ_1; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
PE 2: Evidence at transcript level;
KW Chaperone; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..358
FT /note="DnaJ homolog subfamily C member 18"
FT /id="PRO_0000244085"
FT TRANSMEM 228..248
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 82..146
FT /note="J"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
SQ SEQUENCE 358 AA; 41551 MW; BF8864DAB6D7695A CRC64;
MAATLGSGER WTEAYIDAVR RNKYPEDTPP ESHDPCGCCN CMKAQKEKKS ENEWTQTRQG
EGNSTYSEEQ LLGVQRIKKC RNYYEILGVS RDASDEELKK AYRKLALKFH PDKNCAPGAT
DAFKAIGNAF AVLSNPDKRL RYDEYGDEQV TFTAPRARPY NYYRDFEADI TPEELFNVFF
GGHFPTGNIH MFSNVTDDTY YYRRRHRHER TQTQKEEEEE KPQTTYSAFI QLLPVLVIVI
ISVITQLLAT NPPYSLFYKS TLGYTISRET QNLQVPYFVD KNFDKAYRGA SLHDLEKTIE
KDYIDYIQTS CWKEKQQKSE LTNLAGLYRD ERLKQKAESL KLENCEKLSK LIGLRRGG
