DJC18_MOUSE
ID DJC18_MOUSE Reviewed; 357 AA.
AC Q9CZJ9; Q8R371;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=DnaJ homolog subfamily C member 18;
GN Name=Dnajc18;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo, and Pituitary;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AK012521; BAB28293.1; -; mRNA.
DR EMBL; AK030483; BAC26985.1; -; mRNA.
DR EMBL; BC026452; AAH26452.1; -; mRNA.
DR CCDS; CCDS29148.1; -.
DR RefSeq; NP_083945.1; NM_029669.4.
DR RefSeq; XP_006526406.1; XM_006526343.3.
DR RefSeq; XP_006526407.1; XM_006526344.3.
DR RefSeq; XP_006526408.1; XM_006526345.3.
DR AlphaFoldDB; Q9CZJ9; -.
DR SMR; Q9CZJ9; -.
DR STRING; 10090.ENSMUSP00000025208; -.
DR iPTMnet; Q9CZJ9; -.
DR PhosphoSitePlus; Q9CZJ9; -.
DR EPD; Q9CZJ9; -.
DR MaxQB; Q9CZJ9; -.
DR PaxDb; Q9CZJ9; -.
DR PRIDE; Q9CZJ9; -.
DR ProteomicsDB; 279778; -.
DR Antibodypedia; 26786; 29 antibodies from 12 providers.
DR DNASU; 76594; -.
DR Ensembl; ENSMUST00000025208; ENSMUSP00000025208; ENSMUSG00000024350.
DR GeneID; 76594; -.
DR KEGG; mmu:76594; -.
DR UCSC; uc008emq.2; mouse.
DR CTD; 202052; -.
DR MGI; MGI:1923844; Dnajc18.
DR VEuPathDB; HostDB:ENSMUSG00000024350; -.
DR eggNOG; KOG0714; Eukaryota.
DR GeneTree; ENSGT00940000160925; -.
DR HOGENOM; CLU_043579_3_0_1; -.
DR InParanoid; Q9CZJ9; -.
DR OMA; TGQARHY; -.
DR OrthoDB; 1173544at2759; -.
DR PhylomeDB; Q9CZJ9; -.
DR TreeFam; TF105145; -.
DR BioGRID-ORCS; 76594; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Dnajc18; mouse.
DR PRO; PR:Q9CZJ9; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; Q9CZJ9; protein.
DR Bgee; ENSMUSG00000024350; Expressed in spermatid and 243 other tissues.
DR ExpressionAtlas; Q9CZJ9; baseline and differential.
DR Genevisible; Q9CZJ9; MM.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030544; F:Hsp70 protein binding; IBA:GO_Central.
DR GO; GO:0071218; P:cellular response to misfolded protein; IBA:GO_Central.
DR GO; GO:0051085; P:chaperone cofactor-dependent protein refolding; IBA:GO_Central.
DR GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR CDD; cd06257; DnaJ; 1.
DR Gene3D; 1.10.287.110; -; 1.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR018253; DnaJ_domain_CS.
DR InterPro; IPR015399; DUF1977_DnaJ-like.
DR InterPro; IPR036869; J_dom_sf.
DR Pfam; PF00226; DnaJ; 1.
DR Pfam; PF09320; DUF1977; 1.
DR PRINTS; PR00625; JDOMAIN.
DR SMART; SM00271; DnaJ; 1.
DR SUPFAM; SSF46565; SSF46565; 1.
DR PROSITE; PS00636; DNAJ_1; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
PE 2: Evidence at transcript level;
KW Chaperone; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..357
FT /note="DnaJ homolog subfamily C member 18"
FT /id="PRO_0000244087"
FT TRANSMEM 227..247
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 82..146
FT /note="J"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
FT CONFLICT 44
FT /note="A -> E (in Ref. 2; AAH26452)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 357 AA; 41434 MW; 9798AF2559A6A215 CRC64;
MATTLGSGER WTQAYIDAIR RNKYPEDKRP DSHDPCGCCN CMKAQKEKKS ENEWNQTRQG
EGNATYTEEQ LRGVQRIKKC RNYYDILGVS HNASDEELKK AYKKLALKFH PDKNCAPGAT
EAFKAIGNAF AVLSNPDKRL RYDEYGDEQV TFTVPRARSY HYYKDFEADI SPEELFNVFF
GGHFPSGNIH MFSNVTDDSQ YYRRRHRHER TQTHKREEDK SQTPYSAFVQ LLPVLVIVTI
SVITQLLAAN PPYSLFYKST LGYTISRETQ NLQVPYFVDK NFDKAYRGAS LRDLEKTIEK
DYIDYIQTSC WKEKQQKSEL TNLAGLYRDE RLRQKAESLK LENCAKLSKL IGLRRAG
