ID   DJC21_DANRE             Reviewed;         545 AA.
AC   Q6PGY5;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=DnaJ homolog subfamily C member 21;
DE   AltName: Full=DnaJ homolog subfamily A member 5;
GN   Name=dnajc21; Synonyms=dnaja5; ORFNames=zgc:63563;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as a co-chaperone for HSP70.
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DR   EMBL; BC056785; AAH56785.1; -; mRNA.
DR   RefSeq; NP_956338.1; NM_200044.1.
DR   AlphaFoldDB; Q6PGY5; -.
DR   SMR; Q6PGY5; -.
DR   STRING; 7955.ENSDARP00000074126; -.
DR   PaxDb; Q6PGY5; -.
DR   GeneID; 336984; -.
DR   KEGG; dre:336984; -.
DR   CTD; 134218; -.
DR   ZFIN; ZDB-GENE-030131-8928; dnajc21.
DR   eggNOG; KOG0717; Eukaryota.
DR   InParanoid; Q6PGY5; -.
DR   OrthoDB; 858842at2759; -.
DR   PhylomeDB; Q6PGY5; -.
DR   PRO; PR:Q6PGY5; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd06257; DnaJ; 1.
DR   Gene3D; 1.10.287.110; -; 1.
DR   InterPro; IPR001623; DnaJ_domain.
DR   InterPro; IPR018253; DnaJ_domain_CS.
DR   InterPro; IPR036869; J_dom_sf.
DR   InterPro; IPR003604; Matrin/U1-like-C_Znf_C2H2.
DR   InterPro; IPR041661; ZN622/Rei1/Reh1_Znf-C2H2.
DR   InterPro; IPR022755; Znf_C2H2_jaz.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00226; DnaJ; 1.
DR   Pfam; PF12756; zf-C2H2_2; 1.
DR   Pfam; PF12171; zf-C2H2_jaz; 1.
DR   PRINTS; PR00625; JDOMAIN.
DR   SMART; SM00271; DnaJ; 1.
DR   SMART; SM00355; ZnF_C2H2; 2.
DR   SMART; SM00451; ZnF_U1; 2.
DR   SUPFAM; SSF46565; SSF46565; 1.
DR   SUPFAM; SSF57667; SSF57667; 1.
DR   PROSITE; PS00636; DNAJ_1; 1.
DR   PROSITE; PS50076; DNAJ_2; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE   2: Evidence at transcript level;
KW   Chaperone; Coiled coil; Metal-binding; Reference proteome; Repeat; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..545
FT                   /note="DnaJ homolog subfamily C member 21"
FT                   /id="PRO_0000281476"
FT   DOMAIN          3..69
FT                   /note="J"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
FT   ZN_FING         323..347
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         498..522
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          122..141
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          276..302
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          331..497
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          522..545
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          180..286
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        127..141
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        281..296
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        347..362
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        364..387
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        417..443
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   545 AA;  62766 MW;  68D9049C1FD3740A CRC64;
     MKCHYEVLGV KRDASDDDLK KAYRKLALKW HPDKNLDNAE DAAEQFKLIQ AAYDVLSDPQ
     ERAWYDNHRE ALLKGGVSGE YQDDSIDLVQ FFTVTCYSGY GDDEKGFYAV YRNVFESIVK
     EEKEHSKDEE DEEDEFPSFG ESESDYDTVV HLFYGYWQSF CTRKNFAWKE EYDTRQASNR
     WEKRAMEKEN KKTRDKARKE HNELVRQLVA FVRKRDKRVQ AHKKLVEEQN AEKAKKVEEL
     RRKQKLSQAK LAEDYQEQSW TAMSELEKEL QQMEAEYGQE FGDASDSEEN EEELESRDIA
     NVDGVDAVMA DGAAEMDDYY DDLYCPACDK SFKSDKAMKN HSKSKKHREM VALLRQQLEE
     EDESLSQNCA EREEDDEEED DDDDDEQNDT SKQKLSKRQK KKKRLQKPVN NLPEAPETVS
     PVPQSTEEHL SPAPDSGNTE DTPVPSEDPD DGVKPDGQEN TNQKSTAKTK GKKGGKDSKK
     SSKAHGGVEA APEKEVNLRC VTCQYEFTTR NKLFDHLKST GHATALSSSN TSQTSKKKKD
     SRKNR