DJC22_HUMAN
ID DJC22_HUMAN Reviewed; 341 AA.
AC Q8N4W6; B3KP54;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=DnaJ homolog subfamily C member 22;
GN Name=DNAJC22;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May function as a co-chaperone.
CC -!- INTERACTION:
CC Q8N4W6; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-12162311, EBI-16439278;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AK055747; BAG51566.1; -; mRNA.
DR EMBL; CH471111; EAW58066.1; -; Genomic_DNA.
DR EMBL; BC033236; AAH33236.1; -; mRNA.
DR CCDS; CCDS8785.1; -.
DR RefSeq; NP_001291873.1; NM_001304944.1.
DR RefSeq; NP_079178.2; NM_024902.3.
DR AlphaFoldDB; Q8N4W6; -.
DR SMR; Q8N4W6; -.
DR BioGRID; 123031; 41.
DR IntAct; Q8N4W6; 1.
DR STRING; 9606.ENSP00000446830; -.
DR iPTMnet; Q8N4W6; -.
DR PhosphoSitePlus; Q8N4W6; -.
DR BioMuta; DNAJC22; -.
DR DMDM; 74728914; -.
DR MassIVE; Q8N4W6; -.
DR PaxDb; Q8N4W6; -.
DR PeptideAtlas; Q8N4W6; -.
DR PRIDE; Q8N4W6; -.
DR ProteomicsDB; 71983; -.
DR Antibodypedia; 25951; 86 antibodies from 15 providers.
DR DNASU; 79962; -.
DR Ensembl; ENST00000395069.3; ENSP00000378508.2; ENSG00000178401.16.
DR Ensembl; ENST00000549441.7; ENSP00000446830.1; ENSG00000178401.16.
DR Ensembl; ENST00000647553.1; ENSP00000498036.1; ENSG00000178401.16.
DR GeneID; 79962; -.
DR KEGG; hsa:79962; -.
DR MANE-Select; ENST00000549441.7; ENSP00000446830.1; NM_001304944.2; NP_001291873.1.
DR UCSC; uc001rua.4; human.
DR CTD; 79962; -.
DR GeneCards; DNAJC22; -.
DR HGNC; HGNC:25802; DNAJC22.
DR HPA; ENSG00000178401; Tissue enriched (liver).
DR neXtProt; NX_Q8N4W6; -.
DR OpenTargets; ENSG00000178401; -.
DR PharmGKB; PA162383905; -.
DR VEuPathDB; HostDB:ENSG00000178401; -.
DR eggNOG; KOG0714; Eukaryota.
DR GeneTree; ENSGT00390000012136; -.
DR HOGENOM; CLU_057927_1_0_1; -.
DR InParanoid; Q8N4W6; -.
DR OMA; LASAWWT; -.
DR OrthoDB; 1058581at2759; -.
DR PhylomeDB; Q8N4W6; -.
DR TreeFam; TF324581; -.
DR PathwayCommons; Q8N4W6; -.
DR SignaLink; Q8N4W6; -.
DR BioGRID-ORCS; 79962; 17 hits in 1069 CRISPR screens.
DR ChiTaRS; DNAJC22; human.
DR GenomeRNAi; 79962; -.
DR Pharos; Q8N4W6; Tbio.
DR PRO; PR:Q8N4W6; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q8N4W6; protein.
DR Bgee; ENSG00000178401; Expressed in right lobe of liver and 173 other tissues.
DR ExpressionAtlas; Q8N4W6; baseline and differential.
DR Genevisible; Q8N4W6; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR CDD; cd06257; DnaJ; 1.
DR Gene3D; 1.10.287.110; -; 1.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR036869; J_dom_sf.
DR InterPro; IPR007829; TM2.
DR Pfam; PF00226; DnaJ; 1.
DR Pfam; PF05154; TM2; 1.
DR PRINTS; PR00625; JDOMAIN.
DR SMART; SM00271; DnaJ; 1.
DR SUPFAM; SSF46565; SSF46565; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
PE 1: Evidence at protein level;
KW Chaperone; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..341
FT /note="DnaJ homolog subfamily C member 22"
FT /id="PRO_0000325862"
FT TRANSMEM 5..25
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 218..238
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 277..341
FT /note="J"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
SQ SEQUENCE 341 AA; 38086 MW; 0246AFCB12D09917 CRC64;
MAKGLLVTYA LWAVGGPAGL HHLYLGRDSH ALLWMLTLGG GGLGWLWEFW KLPSFVAQAN
RAQGQRQSPR GVTPPLSPIR FAAQVIVGIY FGLVALISLS SMVNFYIVAL PLAVGLGVLL
VAAVGNQTSD FKNTLGSAFL TSPIFYGRPI AILPISVAAS ITAQRHRRYK ALVASEPLSV
RLYRLGLAYL AFTGPLAYSA LCNTAATLSY VAETFGSFLN WFSFFPLLGR LMEFVLLLPY
RIWRLLMGET GFNSSCFQEW AKLYEFVHSF QDEKRQLAYQ VLGLSEGATN EEIHRSYQEL
VKVWHPDHNL DQTEEAQRHF LEIQAAYEVL SQPRKPWGSR R
