ID   DJC22_MOUSE             Reviewed;         339 AA.
AC   Q8CHS2;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=DnaJ homolog subfamily C member 22;
GN   Name=Dnajc22;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Liver;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: May function as a co-chaperone.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; BC039633; AAH39633.1; -; mRNA.
DR   CCDS; CCDS27815.1; -.
DR   RefSeq; NP_789805.1; NM_176835.2.
DR   RefSeq; XP_006521520.1; XM_006521457.3.
DR   RefSeq; XP_006521522.1; XM_006521459.3.
DR   RefSeq; XP_011244040.1; XM_011245738.1.
DR   AlphaFoldDB; Q8CHS2; -.
DR   SMR; Q8CHS2; -.
DR   STRING; 10090.ENSMUSP00000055482; -.
DR   PhosphoSitePlus; Q8CHS2; -.
DR   MaxQB; Q8CHS2; -.
DR   PaxDb; Q8CHS2; -.
DR   PRIDE; Q8CHS2; -.
DR   ProteomicsDB; 279670; -.
DR   Antibodypedia; 25951; 86 antibodies from 15 providers.
DR   Ensembl; ENSMUST00000061295; ENSMUSP00000055482; ENSMUSG00000038009.
DR   GeneID; 72778; -.
DR   KEGG; mmu:72778; -.
DR   UCSC; uc007xou.1; mouse.
DR   CTD; 79962; -.
DR   MGI; MGI:1920028; Dnajc22.
DR   VEuPathDB; HostDB:ENSMUSG00000038009; -.
DR   eggNOG; KOG0714; Eukaryota.
DR   GeneTree; ENSGT00390000012136; -.
DR   HOGENOM; CLU_057927_1_0_1; -.
DR   InParanoid; Q8CHS2; -.
DR   OMA; LASAWWT; -.
DR   OrthoDB; 1058581at2759; -.
DR   PhylomeDB; Q8CHS2; -.
DR   TreeFam; TF324581; -.
DR   BioGRID-ORCS; 72778; 2 hits in 74 CRISPR screens.
DR   PRO; PR:Q8CHS2; -.
DR   Proteomes; UP000000589; Chromosome 15.
DR   RNAct; Q8CHS2; protein.
DR   Bgee; ENSMUSG00000038009; Expressed in left lobe of liver and 86 other tissues.
DR   Genevisible; Q8CHS2; MM.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   CDD; cd06257; DnaJ; 1.
DR   Gene3D; 1.10.287.110; -; 1.
DR   InterPro; IPR001623; DnaJ_domain.
DR   InterPro; IPR036869; J_dom_sf.
DR   InterPro; IPR007829; TM2.
DR   Pfam; PF00226; DnaJ; 1.
DR   Pfam; PF05154; TM2; 1.
DR   PRINTS; PR00625; JDOMAIN.
DR   SMART; SM00271; DnaJ; 1.
DR   SUPFAM; SSF46565; SSF46565; 1.
DR   PROSITE; PS50076; DNAJ_2; 1.
PE   1: Evidence at protein level;
KW   Chaperone; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..339
FT                   /note="DnaJ homolog subfamily C member 22"
FT                   /id="PRO_0000325863"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        30..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        185..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        218..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          277..339
FT                   /note="J"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
SQ   SEQUENCE   339 AA;  37942 MW;  E0FC1138ACFFE2E0 CRC64;
     MAKGLLMTYV LWALGGPVGL HHLYLGRDSH ALLWMLTLGG GGLGWLWEFW KLPSFVAQAN
     RVQSWKQRPE EERPPLSLLR FASQIVVGVY FGLVALVSLS SMDNFYIVGL PLAVGLGVLL
     VAAVGNQTSD FKNTLGAAFL TSPVFYGRPI AILPISLAAS ITAQKHRRYK ASAGSETLSV
     RLYRVGLAYL AFTGPLAYST MYNTAATINY VAETLGSFLS WFSFFPLLGR LVESVLLLPC
     RIWWLLVGGP GFNSSRFQEW EKLYEFVDSF QDEKLQLAHQ VLGVPEGATN EEIHRSYRDL
     VKVWHPDHNR HQTEEAQRHF LEIQAAYEVL SQPKKPRAS