DJC25_MOUSE
ID DJC25_MOUSE Reviewed; 357 AA.
AC A2ALW5; A2ALW4; Q0VBC8; Q3UWH0;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=DnaJ homolog subfamily C member 25;
GN Name=Dnajc25;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 91-357 (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Heart, Liver, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A2ALW5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A2ALW5-2; Sequence=VSP_035183;
CC -!- SIMILARITY: Belongs to the DNAJC25 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE22945.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAM17653.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL805972; CAM17653.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL805972; CAM17654.2; -; Genomic_DNA.
DR EMBL; BC119039; AAI19040.1; -; mRNA.
DR EMBL; BC120693; AAI20694.1; -; mRNA.
DR EMBL; AK136359; BAE22945.1; ALT_INIT; mRNA.
DR CCDS; CCDS18216.2; -. [A2ALW5-1]
DR RefSeq; NP_001028337.2; NM_001033165.3. [A2ALW5-1]
DR RefSeq; XP_006538338.1; XM_006538275.3. [A2ALW5-2]
DR RefSeq; XP_006538339.1; XM_006538276.3. [A2ALW5-2]
DR AlphaFoldDB; A2ALW5; -.
DR SMR; A2ALW5; -.
DR BioGRID; 215368; 2.
DR STRING; 10090.ENSMUSP00000092680; -.
DR iPTMnet; A2ALW5; -.
DR PhosphoSitePlus; A2ALW5; -.
DR EPD; A2ALW5; -.
DR MaxQB; A2ALW5; -.
DR PaxDb; A2ALW5; -.
DR PeptideAtlas; A2ALW5; -.
DR PRIDE; A2ALW5; -.
DR ProteomicsDB; 279671; -. [A2ALW5-1]
DR ProteomicsDB; 279672; -. [A2ALW5-2]
DR Ensembl; ENSMUST00000095070; ENSMUSP00000092680; ENSMUSG00000070972. [A2ALW5-1]
DR Ensembl; ENSMUST00000152199; ENSMUSP00000118048; ENSMUSG00000070972. [A2ALW5-2]
DR GeneID; 72429; -.
DR KEGG; mmu:72429; -.
DR UCSC; uc008szn.2; mouse. [A2ALW5-1]
DR CTD; 548645; -.
DR MGI; MGI:1919679; Dnajc25.
DR VEuPathDB; HostDB:ENSMUSG00000070972; -.
DR eggNOG; KOG0722; Eukaryota.
DR GeneTree; ENSGT00390000013355; -.
DR HOGENOM; CLU_055735_0_0_1; -.
DR InParanoid; A2ALW5; -.
DR OMA; IGKAYRQ; -.
DR OrthoDB; 1332758at2759; -.
DR PhylomeDB; A2ALW5; -.
DR TreeFam; TF313563; -.
DR BioGRID-ORCS; 72429; 1 hit in 74 CRISPR screens.
DR PRO; PR:A2ALW5; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; A2ALW5; protein.
DR Bgee; ENSMUSG00000070972; Expressed in humerus cartilage element and 147 other tissues.
DR ExpressionAtlas; A2ALW5; baseline and differential.
DR Genevisible; A2ALW5; MM.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR CDD; cd06257; DnaJ; 1.
DR Gene3D; 1.10.287.110; -; 1.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR044632; DNAJC25-like.
DR InterPro; IPR036869; J_dom_sf.
DR PANTHER; PTHR44176; PTHR44176; 1.
DR Pfam; PF00226; DnaJ; 1.
DR PRINTS; PR00625; JDOMAIN.
DR SMART; SM00271; DnaJ; 1.
DR SUPFAM; SSF46565; SSF46565; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Chaperone; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..357
FT /note="DnaJ homolog subfamily C member 25"
FT /id="PRO_0000348570"
FT TRANSMEM 19..39
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 48..121
FT /note="J"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
FT VAR_SEQ 1..119
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_035183"
SQ SEQUENCE 357 AA; 41937 MW; 3E61B62DD4AAAE3E CRC64;
MAARLALRGG PGAAGQRPWL LLAPLLLVPL LARPAEALVE GLYCGTRDCY EVLGVSRSAS
KAEIARAYRQ LARRYHPDRY RPEPGDGPGG APPSAEAFLL VATAYETLKD EETRKDYDYM
LDHPEEYYSH YYHYYSRRLA PKVDVRVVIL VSVCAISMFQ YFSWWNSYNK AISYLATVPK
YRIQATEIAK EQGLLKKAKE KGKNKKSKEE IRDEEENIIK NIIKSKIDIK GGYQKPQVRD
LLLFQVILAP VHLCSYIAWY CRWIYNFNIK GKEYGEEERL YIIRKSMKMS QSQFDSLEDH
QKEMFLKREL WIKENYEVYK QEQEEELKKK LANDPRWKRY RRWMKNEGPG RLTFVDD
